caa a22 4500 605520704 CHVBK 20210128100736.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00223-015-0027-0 doi (NATIONALLICENCE)springer-10.1007/s00223-015-0027-0 Physical Activity, Bone Health, and Obesity in Peri-/Pre- and Postmenopausal Women: Results from the EPIC-Potsdam Study [Elektronische Daten] [Juliane Menzel, Romina di Giuseppe, Angelika Wientzek, Anja Kroke, Heiner Boeing, Cornelia Weikert] Physical activity (PA) is suggested to increase the peak bone mass and to minimize age-related bone loss, and thereby to reduce the risk of osteoporosis. However, the relation between PA and bone health considering the obesity status is unclear so far. The present study examines the association between PA levels and calcaneal broadband ultrasound attenuation (BUA), particularly under consideration of obesity. Data from a population-based sample of 6776 German women from the EPIC-Potsdam cohort were analyzed. Calibrated PA data were used. Statistical analyses were stratified by menopausal and obesity status. Multiple linear regression was used to model the relationship between PA and BUA levels after adjustment for age, body mass index (BMI), smoking status, education, alcohol and calcium intake, and hormone use. Peri-/premenopausal had higher BUA levels (112.39±10.05dB/MHz) compared to postmenopausal women (106.44±9.95dB/MHz). In both groups, BUA levels were higher in the fourth compared to the lowest quartile of PA (p for trend<0.05). In women with BMI<30, but not BMI≥30kg/m2, PA remained positively associated with BUA levels (p for interaction=0.03). However, when waist circumference higher than 88cm or body fat percentage (BF%) measures above the median were used to define obesity, a significant positive relationship was also observed in women with BMI<30kg/m2 but with higher waist circumference or BF%. In conclusion, our results strengthen the hypothesis that PA has a positive influence on BUA levels, though dependent on weight. The Author(s), 2015 Bone mineral density nationallicence Physical activity nationallicence Broadband ultrasound attenuation nationallicence Bone loss nationallicence Obesity nationallicence Menzel Juliane Research Group Cardiovascular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany aut di Giuseppe Romina Research Group Cardiovascular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany aut Wientzek Angelika Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany aut Kroke Anja Department of Nutritional, Food and Consumer Sciences, Fulda University of Applied Sciences, Fulda, Germany aut Boeing Heiner Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany aut Weikert Cornelia Research Group Cardiovascular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany aut Calcified Tissue International Springer US; http://www.springer-ny.com 97/4(2015-10-01), 376-384 0171-967X 97:4<376 2015 97 223 https://doi.org/10.1007/s00223-015-0027-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00223-015-0027-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Menzel Juliane Research Group Cardiovascular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany aut NATIONALLICENCE 700 1- di Giuseppe Romina Research Group Cardiovascular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany aut NATIONALLICENCE 700 1- Wientzek Angelika Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany aut NATIONALLICENCE 700 1- Kroke Anja Department of Nutritional, Food and Consumer Sciences, Fulda University of Applied Sciences, Fulda, Germany aut NATIONALLICENCE 700 1- Boeing Heiner Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany aut NATIONALLICENCE 700 1- Weikert Cornelia Research Group Cardiovascular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany aut NATIONALLICENCE 773 0- Calcified Tissue International Springer US; http://www.springer-ny.com 97/4(2015-10-01), 376-384 0171-967X 97:4<376 2015 97 223