caa a22 4500 605520739 CHVBK 20210128100736.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00223-015-9990-8 doi (NATIONALLICENCE)springer-10.1007/s00223-015-9990-8 Reduction in Endogenous Insulin Secretion is a Risk Factor of Sarcopenia in Men with Type 2 Diabetes Mellitus [Elektronische Daten] [Ken-ichiro Tanaka, Ippei Kanazawa, Toshitsugu Sugimoto] Sarcopenia has recently attracted widespread attention, because it increases risks of fall and bedridden. Although patients with type 2 diabetes mellitus (T2DM) are known to have lower muscle mass of limbs than healthy people, the mechanism is still unclear. We thus examined the association of muscle mass with parameters of endogenous insulin secretion such as fasting immunoreactive insulin, fasting C-peptide immunoreactivity(CPR), and daily urine CPR in 191 men with T2DM. Muscle mass of arms and legs was evaluated by dual-energy X-ray absorptiometry, and we calculated relative skeletal muscle index (RSMI), which is useful for the diagnosis of sarcopenia. Multiple regression analyses adjusted for age, duration of T2DM, serum creatinine, HbA1c, and insulin-like growth factor-I showed that each parameter of endogenous insulin was significantly and positively correlated with muscle mass of arms and legs as well as RSMI (p<0.05). Moreover, logistic regression analyses adjusted for confounding factors mentioned above showed that each parameter of endogenous insulin was significantly lower in subjects with sarcopenia than those without it (p<0.05). In conclusion, reduction in endogenous insulin secretion is an independent risk factor of sarcopenia in men with T2DM. Springer Science+Business Media New York, 2015 Sarcopenia nationallicence Insulin secretion nationallicence Diabetes mellitus nationallicence Skeletal muscle mass nationallicence IGF-Ι nationallicence Tanaka Ken-ichiro Department of Internal Medicine, Shimane University Faculty of Medicine, 693-8501, Izumo, Japan aut Kanazawa Ippei Department of Internal Medicine, Shimane University Faculty of Medicine, 693-8501, Izumo, Japan aut Sugimoto Toshitsugu Department of Internal Medicine, Shimane University Faculty of Medicine, 693-8501, Izumo, Japan aut Calcified Tissue International Springer US; http://www.springer-ny.com 97/4(2015-10-01), 385-390 0171-967X 97:4<385 2015 97 223 https://doi.org/10.1007/s00223-015-9990-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00223-015-9990-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tanaka Ken-ichiro Department of Internal Medicine, Shimane University Faculty of Medicine, 693-8501, Izumo, Japan aut NATIONALLICENCE 700 1- Kanazawa Ippei Department of Internal Medicine, Shimane University Faculty of Medicine, 693-8501, Izumo, Japan aut NATIONALLICENCE 700 1- Sugimoto Toshitsugu Department of Internal Medicine, Shimane University Faculty of Medicine, 693-8501, Izumo, Japan aut NATIONALLICENCE 773 0- Calcified Tissue International Springer US; http://www.springer-ny.com 97/4(2015-10-01), 385-390 0171-967X 97:4<385 2015 97 223