caa a22 4500 605520771 CHVBK 20210128100737.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00223-015-0018-1 doi (NATIONALLICENCE)springer-10.1007/s00223-015-0018-1 Fat Infiltration in the Leg is Associated with Bone Geometry and Physical Function in Healthy Older Women [Elektronische Daten] [Amanda Lorbergs, Michael Noseworthy, Jonathan Adachi, Paul Stratford, Norma MacIntyre] The objective of this study was to estimate the associations between muscular fat infiltration, tibia bone mineral quantity and distribution, and physical function in healthy older women. Thirty-five women (aged 60-75years, mean 70years) were recruited from the community. Percent intramuscular fat (%IntraMF) within the right leg tibialis anterior, soleus, and gastrocnemius muscles and total intermuscular fat (IMF) were segmented from magnetic resonance imaging scans at the mid-calf. Intramyocellular lipid (IMCL) content in the right tibialis anterior was measured with proton magnetic resonance spectroscopy. Right tibia bone content, area, and strength were measured at the 4, 14, and 66% sites using peripheral quantitative computed tomography. Physical function was assessed by gait speed on the 20m walking test. After adjusting for age, body size, and activity level, %IntraMF had a negative association with bone content and area at all tibia sites (r=−0.31 to −0.03). Conversely, greater IMF was associated with increased bone content and area (r=0.04-0.32). Correlation coefficients for the association between IMCL and bone were negative (r=−0.44 to −0.03). All measures of fat infiltration had a negative association with observed physical function (r=−0.42 to −0.04). Our findings suggest that muscular fat infiltration in the leg of healthy postmenopausal women has a compartment-specific relationship with bone status and physical function. Minimizing fat accumulation within and between muscle compartments may prevent bone fragility and functional decline in women. Springer Science+Business Media New York, 2015 Aged nationallicence Adipose tissue nationallicence Magnetic resonance imaging (MRI) nationallicence Proton magnetic resonance spectroscopy (1H MRS) nationallicence X-ray computed tomography nationallicence Mobility limitation nationallicence Lorbergs Amanda Institute for Aging Research, Hebrew SeniorLife and Harvard Medical School, 1200 Centre St., Rm. 620, 02131, Boston, MA, USA aut Noseworthy Michael School of Biomedical Engineering, McMaster University, 1280 Main Street West, ETB 406, L8S 4K1, Hamilton, ON, Canada aut Adachi Jonathan Department of Medicine, McMaster University, 501-25 Charlton Ave East, L8N 1Y2, Hamilton, ON, Canada aut Stratford Paul School of Rehabilitation Science, McMaster University, 1400 Main Street West, IAHS 403, L8S 1C7, Hamilton, ON, Canada aut MacIntyre Norma School of Rehabilitation Science, McMaster University, 1400 Main Street West, IAHS 403, L8S 1C7, Hamilton, ON, Canada aut Calcified Tissue International Springer US; http://www.springer-ny.com 97/4(2015-10-01), 353-363 0171-967X 97:4<353 2015 97 223 https://doi.org/10.1007/s00223-015-0018-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00223-015-0018-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lorbergs Amanda Institute for Aging Research, Hebrew SeniorLife and Harvard Medical School, 1200 Centre St., Rm. 620, 02131, Boston, MA, USA aut NATIONALLICENCE 700 1- Noseworthy Michael School of Biomedical Engineering, McMaster University, 1280 Main Street West, ETB 406, L8S 4K1, Hamilton, ON, Canada aut NATIONALLICENCE 700 1- Adachi Jonathan Department of Medicine, McMaster University, 501-25 Charlton Ave East, L8N 1Y2, Hamilton, ON, Canada aut NATIONALLICENCE 700 1- Stratford Paul School of Rehabilitation Science, McMaster University, 1400 Main Street West, IAHS 403, L8S 1C7, Hamilton, ON, Canada aut NATIONALLICENCE 700 1- MacIntyre Norma School of Rehabilitation Science, McMaster University, 1400 Main Street West, IAHS 403, L8S 1C7, Hamilton, ON, Canada aut NATIONALLICENCE 773 0- Calcified Tissue International Springer US; http://www.springer-ny.com 97/4(2015-10-01), 353-363 0171-967X 97:4<353 2015 97 223