caa a22 4500 60552078X CHVBK 20210128100737.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00223-015-0025-2 doi (NATIONALLICENCE)springer-10.1007/s00223-015-0025-2 Abnormal Bone Mechanical and Structural Properties in Adolescent Idiopathic Scoliosis: A Study with Finite Element Analysis and Structural Model Index [Elektronische Daten] [K. Cheuk, T. Zhu, F. Yu, V. Hung, K. Lee, L. Qin, J. Cheng, T. Lam] Previous studies found adolescent idiopathic scoliosis (AIS) is associated with low bone mineral density (BMD) and abnormal bone quality, whilst the association between AIS and their bone strength is unknown. From high-resolution peripheral quantitative computed tomography-generated images, bone mechanical properties can be evaluated with finite element analysis (FEA), and trabecular rod-plate configuration related to trabecular bone strength can be quantified by structure model index (SMI). This study aimed to compare trabecular configuration and bone mechanical properties between AIS and the controls. 95 AIS girls aged 12-14years and 97 age- and gender-matched normal controls were recruited. Bilateral femoral necks and non-dominant distal radius were scanned by dual-energy X-ray absorptiometry for areal BMD and HR-pQCT for SMI and FEA, respectively. Subjects were further classified into osteopenic and non-osteopenic group based on their areal BMD. Bone mechanical properties (stiffness, failure load and apparent modulus) were calculated using FEA. Linear regression model was used for controlling age, physical activity and calcium intake. AIS was associated with lower failure load and apparent modulus after adjusting for age, whereas AIS was associated with lower apparent modulus after adjusting for all confounders. Osteopenic AIS was associated with more rod-like trabeculae when compared with non-osteopenic AIS, whereas no difference was detected between osteopenic and non-osteopenic controls. This might be the result of abnormal regulation and modulation of bone metabolism and bone modelling and remodelling in AIS which will warrant future studies with a longitudinal design to determine the significance of micro-architectural abnormalities in AIS. Springer Science+Business Media New York, 2015 Adolescent idiopathic scoliosis nationallicence Osteopenia nationallicence Bone mechanical properties nationallicence Finite element analysis nationallicence Rod-plate configuration nationallicence Structure model index nationallicence Cheuk K. Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Shatin, Hong Kong, China aut Zhu T. Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Shatin, Hong Kong, China aut Yu F. Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Shatin, Hong Kong, China aut Hung V. Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Shatin, Hong Kong, China aut Lee K. Joint Scoliosis Research Center of the Chinese University of Hong Kong and Nanjing University, Hong Kong and Nanjing, China aut Qin L. Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Shatin, Hong Kong, China aut Cheng J. Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Shatin, Hong Kong, China aut Lam T. Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Shatin, Hong Kong, China aut Calcified Tissue International Springer US; http://www.springer-ny.com 97/4(2015-10-01), 343-352 0171-967X 97:4<343 2015 97 223 https://doi.org/10.1007/s00223-015-0025-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00223-015-0025-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cheuk K. Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Shatin, Hong Kong, China aut NATIONALLICENCE 700 1- Zhu T. Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Shatin, Hong Kong, China aut NATIONALLICENCE 700 1- Yu F. Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Shatin, Hong Kong, China aut NATIONALLICENCE 700 1- Hung V. Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Shatin, Hong Kong, China aut NATIONALLICENCE 700 1- Lee K. Joint Scoliosis Research Center of the Chinese University of Hong Kong and Nanjing University, Hong Kong and Nanjing, China aut NATIONALLICENCE 700 1- Qin L. Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Shatin, Hong Kong, China aut NATIONALLICENCE 700 1- Cheng J. Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Shatin, Hong Kong, China aut NATIONALLICENCE 700 1- Lam T. Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Shatin, Hong Kong, China aut NATIONALLICENCE 773 0- Calcified Tissue International Springer US; http://www.springer-ny.com 97/4(2015-10-01), 343-352 0171-967X 97:4<343 2015 97 223