caa a22 4500 60552081X CHVBK 20210128100737.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00223-015-0014-5 doi (NATIONALLICENCE)springer-10.1007/s00223-015-0014-5 Regional Heterogeneity in the Configuration of the Intracortical Canals of the Femoral Shaft [Elektronische Daten] [Egon Perilli, Yohann Bala, Roger Zebaze, Karen Reynolds, Ego Seeman] Three-dimensional (3D) characterization of cortical porosity, most of which is under 100µm in diameter, is usually confined to measurements made in 3-4mm diameter cylinders of bone. We used micro-computed tomography (micro-CT) scanning of entire transaxial cross sections of human proximal femoral shafts (30-35mm diameter) to quantify regional variation in porosity within the same scan. Complete, up to 10-mm-thick, transaxial slices of femoral upper shafts from 8 female cadavers were studied (n=3 aged 29-37years, n=5 aged 72-90years). Scanning was performed using high-resolution micro-CT (8.65µm/voxel). Micro-CT volumes (10×10×5mm) were selected via software in the anterior, medial and lateral regions. Images were segmented with voids appearing as 3D-interconnected canals. The percent void-to-tissue volume (Vo.V/TV) and the corresponding void surface area/TV were 86-309% higher in older than younger subjects in anterior (p=0.034), medial (p=0.077), and lateral aspects (p=0.034). Although not significant, void separation was reciprocally lower by 19-39%, and void diameter was 65% larger in older than younger subjects; void number tended to be 24-25% higher medially and laterally but not anteriorly. For all specimens combined, medially there was higher Vo.V/TV and void surface area/TV than anteriorly (+48%, p=0.018; +33%, p=0.018) and laterally (+56%, p=0.062; +36%, p=0.043). There is regional heterogeneity in the 3D microarchitecture of the intracortical canals of the femoral shaft. The higher void volume in advanced age appears to be due to larger, rather than more, pores. However, creation of new canals from existing canals may contribute, depending on the location. High-resolution micro-computed tomography scanning of entire bone segments enables quantification of the 3D microanatomy of the intracortical void network at multiple locations. Springer Science+Business Media New York, 2015 Cortical bone nationallicence Micro-CT nationallicence Osteoporosis nationallicence Porosity nationallicence Voids nationallicence Perilli Egon Medical Device Research Institute, School of Computer Science, Engineering and Mathematics, Flinders University, GPO Box 2100, 5001, Adelaide, SA, Australia aut Bala Yohann Department of Endocrinology, Austin Health, University of Melbourne, Melbourne, VIC, Australia aut Zebaze Roger Department of Endocrinology, Austin Health, University of Melbourne, Melbourne, VIC, Australia aut Reynolds Karen Medical Device Research Institute, School of Computer Science, Engineering and Mathematics, Flinders University, GPO Box 2100, 5001, Adelaide, SA, Australia aut Seeman Ego Departments of Endocrinology and Medicine, Austin Health, University of Melbourne, Melbourne, VIC, Australia aut Calcified Tissue International Springer US; http://www.springer-ny.com 97/4(2015-10-01), 327-335 0171-967X 97:4<327 2015 97 223 https://doi.org/10.1007/s00223-015-0014-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00223-015-0014-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Perilli Egon Medical Device Research Institute, School of Computer Science, Engineering and Mathematics, Flinders University, GPO Box 2100, 5001, Adelaide, SA, Australia aut NATIONALLICENCE 700 1- Bala Yohann Department of Endocrinology, Austin Health, University of Melbourne, Melbourne, VIC, Australia aut NATIONALLICENCE 700 1- Zebaze Roger Department of Endocrinology, Austin Health, University of Melbourne, Melbourne, VIC, Australia aut NATIONALLICENCE 700 1- Reynolds Karen Medical Device Research Institute, School of Computer Science, Engineering and Mathematics, Flinders University, GPO Box 2100, 5001, Adelaide, SA, Australia aut NATIONALLICENCE 700 1- Seeman Ego Departments of Endocrinology and Medicine, Austin Health, University of Melbourne, Melbourne, VIC, Australia aut NATIONALLICENCE 773 0- Calcified Tissue International Springer US; http://www.springer-ny.com 97/4(2015-10-01), 327-335 0171-967X 97:4<327 2015 97 223