caa a22 4500 605520852 CHVBK 20210128100737.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00223-015-0043-0 doi (NATIONALLICENCE)springer-10.1007/s00223-015-0043-0 Effects of Yerba Mate ( IIex paraguariensis ) on Histomorphometry, Biomechanics, and Densitometry on Bones in the Rat [Elektronische Daten] [Lucas Brun, María Brance, Mercedes Lombarte, María Maher, Verónica Di Loreto, Alfredo Rigalli] Yerba mate (Ilex paraguariensis) is a xanthine-containing beverage, which is also rich in caffeine. Because caffeine has a negative impact on bone mineral density (BMD) mainly associated with low calcium (Ca) diets, there would be expected a negative effect of yerba mate on bone. In this study, Sprague-Dawley rats were used and randomly assigned into four groups (n=6/group): Control+Ca 0.2g%; Control+Ca 0.9g%; Yerba+Ca 0.2g%; Yerba+Ca 0.9g%. At the end of the experiment, tibias and femurs were obtained for BMD, morphometric, histomorphometric, and biomechanical analyses. While there was no difference in bone parameters between rats with and without yerba mate consumption, a negative effect of low Ca diet was observed in BMD, morphometric, histomorphometric, and biomechanical results. Interaction between Ca content in the diet and yerba mate was only found in trabecular bone volume, which would indicate that the negative effect of low Ca intake on bone volume is reversed in part by yerba mate infusion. However, yerba mate was not able to reverse the negative effect of low Ca content on biomechanical properties and trabecular connectivity. In summary, at least in our study, yerba mate would not have a negative effect on bone and would be safe for the bone health of consumers. Springer Science+Business Media New York, 2015 Ilex paraguariensis nationallicence Yerba mate nationallicence Bone nationallicence Brun Lucas Bone Biology Laboratory, School of Medicine, Rosario National University, Rosario, Argentina aut Brance María Bone Biology Laboratory, School of Medicine, Rosario National University, Rosario, Argentina aut Lombarte Mercedes Bone Biology Laboratory, School of Medicine, Rosario National University, Rosario, Argentina aut Maher María Bone Biology Laboratory, School of Medicine, Rosario National University, Rosario, Argentina aut Di Loreto Verónica Bone Biology Laboratory, School of Medicine, Rosario National University, Rosario, Argentina aut Rigalli Alfredo Bone Biology Laboratory, School of Medicine, Rosario National University, Rosario, Argentina aut Calcified Tissue International Springer US; http://www.springer-ny.com 97/5(2015-11-01), 527-534 0171-967X 97:5<527 2015 97 223 https://doi.org/10.1007/s00223-015-0043-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00223-015-0043-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Brun Lucas Bone Biology Laboratory, School of Medicine, Rosario National University, Rosario, Argentina aut NATIONALLICENCE 700 1- Brance María Bone Biology Laboratory, School of Medicine, Rosario National University, Rosario, Argentina aut NATIONALLICENCE 700 1- Lombarte Mercedes Bone Biology Laboratory, School of Medicine, Rosario National University, Rosario, Argentina aut NATIONALLICENCE 700 1- Maher María Bone Biology Laboratory, School of Medicine, Rosario National University, Rosario, Argentina aut NATIONALLICENCE 700 1- Di Loreto Verónica Bone Biology Laboratory, School of Medicine, Rosario National University, Rosario, Argentina aut NATIONALLICENCE 700 1- Rigalli Alfredo Bone Biology Laboratory, School of Medicine, Rosario National University, Rosario, Argentina aut NATIONALLICENCE 773 0- Calcified Tissue International Springer US; http://www.springer-ny.com 97/5(2015-11-01), 527-534 0171-967X 97:5<527 2015 97 223