Uremia Induces Dental Pulp Ossification but Reciprocally Inhibits Adjacent Alveolar Bone Osteogenesis
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| 024 | 7 | 0 | |a 10.1007/s00223-015-0030-5 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00223-015-0030-5 | ||
| 245 | 0 | 0 | |a Uremia Induces Dental Pulp Ossification but Reciprocally Inhibits Adjacent Alveolar Bone Osteogenesis |h [Elektronische Daten] |c [Chih-Yu Yang, Zee-Fen Chang, Yat-Pang Chau, Ann Chen, Oscar Lee, An-Hang Yang] |
| 520 | 3 | |a Uremic patients are predisposed to atrophy of the alveolar bone and narrowing of the dental pulp chamber. Such pulp chamber changes have only been diagnosed radiologically; however, this has not been supported by any pathological evidence. We used a uremic rat model with secondary hyperparathyroidism induced by 5/6 nephrectomy surgery and high-phosphate diet to examine the dental pulp and adjacent alveolar bone pathology. In addition, we collected pulp tissues for real-time PCR. We found an opposite histopathological presentation of the ossified dental pulp and the osteomalacic adjacent alveolar bone. Furthermore, pulp cells with positive staining for Thy-1, a surrogate stem cell marker, were significantly reduced in the pulp of uremic rats compared to the controls, indicating a paucity of stem cells. This was further evidenced by the reduced pulp expression of dickkopf-1 (Dkk-1), a Wnt/β-catenin signaling inhibitor produced by mesenchymal stem cells. In contrast, expressions of receptor activator of nuclear factor κB ligand (RANKL) and RANK in uremic pulp were up-regulated, probably to counteract the ossifying process of uremic pulp. In conclusion, uremic pulp ossifications were associated with a paucity of stem cells and dysregulated Dkk-1 and RANKL signaling systems, further shifting the imbalance toward osteogenesis. Strategies to counteract such an imbalance may offer a potential therapeutic target to improve dental health in uremic patients, which warrants further interventional studies. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a Uremia |2 nationallicence | |
| 690 | 7 | |a Pulp ossification |2 nationallicence | |
| 690 | 7 | |a Stem cells |2 nationallicence | |
| 690 | 7 | |a Dickkopf-1 |2 nationallicence | |
| 690 | 7 | |a RANKL |2 nationallicence | |
| 690 | 7 | |a Osteomalacia |2 nationallicence | |
| 700 | 1 | |a Yang |D Chih-Yu |u Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan |4 aut | |
| 700 | 1 | |a Chang |D Zee-Fen |u Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei, Taiwan |4 aut | |
| 700 | 1 | |a Chau |D Yat-Pang |u Department of Medicine, Mackay Medical College, New Taipei City, Taiwan |4 aut | |
| 700 | 1 | |a Chen |D Ann |u Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan |4 aut | |
| 700 | 1 | |a Lee |D Oscar |u Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan |4 aut | |
| 700 | 1 | |a Yang |D An-Hang |u Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan |4 aut | |
| 773 | 0 | |t Calcified Tissue International |d Springer US; http://www.springer-ny.com |g 97/5(2015-11-01), 466-475 |x 0171-967X |q 97:5<466 |1 2015 |2 97 |o 223 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00223-015-0030-5 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00223-015-0030-5 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yang |D Chih-Yu |u Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Chang |D Zee-Fen |u Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei, Taiwan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Chau |D Yat-Pang |u Department of Medicine, Mackay Medical College, New Taipei City, Taiwan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Chen |D Ann |u Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Lee |D Oscar |u Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yang |D An-Hang |u Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Calcified Tissue International |d Springer US; http://www.springer-ny.com |g 97/5(2015-11-01), 466-475 |x 0171-967X |q 97:5<466 |1 2015 |2 97 |o 223 | ||