Characterisation of Osteoprotegerin Autoantibodies in Coeliac Disease
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| 024 | 7 | 0 | |a 10.1007/s00223-015-0023-4 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00223-015-0023-4 | ||
| 245 | 0 | 0 | |a Characterisation of Osteoprotegerin Autoantibodies in Coeliac Disease |h [Elektronische Daten] |c [Ana Real, Nick Gilbert, Barbara Hauser, Nick Kennedy, Alan Shand, Helen Gillett, Peter Gillett, Clive Goddard, Ángel Cebolla, Carolina Sousa, William Fraser, Jack Satsangi, Stuart Ralston, Philip Riches] |
| 520 | 3 | |a Autoantibodies neutralising the effect of the bone regulatory cytokine osteoprotegerin (OPG) have been described in a patient with severe osteoporosis and coeliac disease. This study aimed to determine the prevalence and epitope specificity of autoantibodies to OPG in patients with coeliac disease, and correlate their presence with bone mineral density. A direct enzyme-linked immunosorbent assay was developed and used to screen patients with coeliac disease for autoantibodies to OPG. Recombinant fragments of OPG were made to evaluate the epitope specificity and affinity of these antibodies. Phenotype information of the patients was obtained by case note review. Raised titres of antibodies to OPG were found in 7/71 (9.8%) patients with coeliac disease, compared with 1/72 (1.4%) non-coeliac osteoporosis clinic control patients (p<0.05). Our results suggest that a polyclonal antibody response to OPG is raised in these patients capable of recognising different epitopes of OPG with varying affinity. The titre of OPG antibodies was associated with lower bone mineral density Z-score of the hip in coeliac patients on univariate (p<0.05) and multivariate analysis including age, sex height and weight as covariates (p<0.01). Polyclonal antibodies to OPG are more common in patients with coeliac disease and are independently associated with lower bone mineral density Z-scores of the hip. Further work is required to establish the clinical utility of testing for OPG antibodies. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a Osteoporosis |2 nationallicence | |
| 690 | 7 | |a Coeliac disease |2 nationallicence | |
| 690 | 7 | |a Osteoprotegerin |2 nationallicence | |
| 690 | 7 | |a Autoantibodies |2 nationallicence | |
| 700 | 1 | |a Real |D Ana |u Centre for Genomics and Experimental Medicine, Institute of Genetics and Molecular Medicine (IGMM), Edinburgh, EH4 2XU, UK |4 aut | |
| 700 | 1 | |a Gilbert |D Nick |u Human Genetics Unit, IGMM, Edinburgh, UK |4 aut | |
| 700 | 1 | |a Hauser |D Barbara |u Centre for Genomics and Experimental Medicine, Institute of Genetics and Molecular Medicine (IGMM), Edinburgh, EH4 2XU, UK |4 aut | |
| 700 | 1 | |a Kennedy |D Nick |u Centre for Genomics and Experimental Medicine, Institute of Genetics and Molecular Medicine (IGMM), Edinburgh, EH4 2XU, UK |4 aut | |
| 700 | 1 | |a Shand |D Alan |u Gastroenterology Department, Lothian University Hospitals NHS Trust, Edinburgh, UK |4 aut | |
| 700 | 1 | |a Gillett |D Helen |u Gastroenterology Department, Lothian University Hospitals NHS Trust, Edinburgh, UK |4 aut | |
| 700 | 1 | |a Gillett |D Peter |u Gastroenterology Department, Lothian University Hospitals NHS Trust, Edinburgh, UK |4 aut | |
| 700 | 1 | |a Goddard |D Clive |u Gastroenterology Department, Lothian University Hospitals NHS Trust, Edinburgh, UK |4 aut | |
| 700 | 1 | |a Cebolla |D Ángel |u Biomedal SL, Seville, Spain |4 aut | |
| 700 | 1 | |a Sousa |D Carolina |u Departamento de Microbiología y Parasitología, Facultad de Farmacia, Universidad de Sevilla, Seville, Spain |4 aut | |
| 700 | 1 | |a Fraser |D William |u University of East Anglia, Norwich, UK |4 aut | |
| 700 | 1 | |a Satsangi |D Jack |u Centre for Genomics and Experimental Medicine, Institute of Genetics and Molecular Medicine (IGMM), Edinburgh, EH4 2XU, UK |4 aut | |
| 700 | 1 | |a Ralston |D Stuart |u Centre for Genomics and Experimental Medicine, Institute of Genetics and Molecular Medicine (IGMM), Edinburgh, EH4 2XU, UK |4 aut | |
| 700 | 1 | |a Riches |D Philip |u Centre for Genomics and Experimental Medicine, Institute of Genetics and Molecular Medicine (IGMM), Edinburgh, EH4 2XU, UK |4 aut | |
| 773 | 0 | |t Calcified Tissue International |d Springer US; http://www.springer-ny.com |g 97/2(2015-08-01), 125-133 |x 0171-967X |q 97:2<125 |1 2015 |2 97 |o 223 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00223-015-0023-4 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00223-015-0023-4 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Real |D Ana |u Centre for Genomics and Experimental Medicine, Institute of Genetics and Molecular Medicine (IGMM), Edinburgh, EH4 2XU, UK |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Gilbert |D Nick |u Human Genetics Unit, IGMM, Edinburgh, UK |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Hauser |D Barbara |u Centre for Genomics and Experimental Medicine, Institute of Genetics and Molecular Medicine (IGMM), Edinburgh, EH4 2XU, UK |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kennedy |D Nick |u Centre for Genomics and Experimental Medicine, Institute of Genetics and Molecular Medicine (IGMM), Edinburgh, EH4 2XU, UK |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Shand |D Alan |u Gastroenterology Department, Lothian University Hospitals NHS Trust, Edinburgh, UK |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Gillett |D Helen |u Gastroenterology Department, Lothian University Hospitals NHS Trust, Edinburgh, UK |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Gillett |D Peter |u Gastroenterology Department, Lothian University Hospitals NHS Trust, Edinburgh, UK |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Goddard |D Clive |u Gastroenterology Department, Lothian University Hospitals NHS Trust, Edinburgh, UK |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Cebolla |D Ángel |u Biomedal SL, Seville, Spain |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sousa |D Carolina |u Departamento de Microbiología y Parasitología, Facultad de Farmacia, Universidad de Sevilla, Seville, Spain |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Fraser |D William |u University of East Anglia, Norwich, UK |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Satsangi |D Jack |u Centre for Genomics and Experimental Medicine, Institute of Genetics and Molecular Medicine (IGMM), Edinburgh, EH4 2XU, UK |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ralston |D Stuart |u Centre for Genomics and Experimental Medicine, Institute of Genetics and Molecular Medicine (IGMM), Edinburgh, EH4 2XU, UK |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Riches |D Philip |u Centre for Genomics and Experimental Medicine, Institute of Genetics and Molecular Medicine (IGMM), Edinburgh, EH4 2XU, UK |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Calcified Tissue International |d Springer US; http://www.springer-ny.com |g 97/2(2015-08-01), 125-133 |x 0171-967X |q 97:2<125 |1 2015 |2 97 |o 223 | ||