caa a22 4500 605521034 CHVBK 20210128100738.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00223-014-9936-6 doi (NATIONALLICENCE)springer-10.1007/s00223-014-9936-6 Age- and Sex-Related Patterns of First Fracture and Fracture Prevalence [Elektronische Daten] [Kara Holloway, Sharon Brennan, Mark Kotowicz, Gosia Bucki-Smith, Amelia Dobbins, Elizabeth Timney, Lana Williams, Julie Pasco] There are few data documenting the pattern of prevalent fracture across the entire adult age range, so we aimed to address this gap by investigating the prevalence of fractures in an Australian cohort. All-cause (ever) fractures were identified for males and females enrolled in the Geelong Osteoporosis Study (Australia) using a combination of radiology-confirmed and self-reported data. First fractures were used to generate age-related frequencies of individuals who had ever sustained a fracture. Of 1,538 males and 1,731 females, 927 males and 856 females had sustained at least one fracture since birth. The proportion of all prevalent fractures in the 0-10year age group was similar for both sexes (~10%). In males, the proportion with prevalent fracture increased to 34.1% for age 11-20year. Smaller increases were observed into mid-life, reaching a plateau at ~50% from mid to late life. The age-related prevalence of fracture for females showed a more gradual increase until mid-life. For adulthood prevalent fractures, approximately 20% of males had sustained a first adulthood fracture in the 20-30year age group, with a gradual increase up to the oldest age group (49.1%), while females showed an exponential pattern of increase from the 20-30year age group (6.8%) to the oldest age group (60.4%). In both sexes, those who had not sustained a fracture in childhood or early adulthood generally appeared to remain fracture-free until at least the sixth decade. When considering the prevalence of adulthood fractures across the age groups, males showed a gradual increase while females showed an exponential increase. Springer Science+Business Media New York, 2014 Fracture prevalence nationallicence Fracture nationallicence Adult nationallicence Adult prevalent fracture nationallicence Holloway Kara School of Medicine, Epi-Centre for Healthy Ageing, Deakin University, 285 Ryrie Street, PO Box 281, 3220, Geelong, VIC, Australia aut Brennan Sharon School of Medicine, Epi-Centre for Healthy Ageing, Deakin University, 285 Ryrie Street, PO Box 281, 3220, Geelong, VIC, Australia aut Kotowicz Mark School of Medicine, Epi-Centre for Healthy Ageing, Deakin University, 285 Ryrie Street, PO Box 281, 3220, Geelong, VIC, Australia aut Bucki-Smith Gosia School of Medicine, Epi-Centre for Healthy Ageing, Deakin University, 285 Ryrie Street, PO Box 281, 3220, Geelong, VIC, Australia aut Dobbins Amelia School of Medicine, Epi-Centre for Healthy Ageing, Deakin University, 285 Ryrie Street, PO Box 281, 3220, Geelong, VIC, Australia aut Timney Elizabeth School of Medicine, Epi-Centre for Healthy Ageing, Deakin University, 285 Ryrie Street, PO Box 281, 3220, Geelong, VIC, Australia aut Williams Lana School of Medicine, Epi-Centre for Healthy Ageing, Deakin University, 285 Ryrie Street, PO Box 281, 3220, Geelong, VIC, Australia aut Pasco Julie School of Medicine, Epi-Centre for Healthy Ageing, Deakin University, 285 Ryrie Street, PO Box 281, 3220, Geelong, VIC, Australia aut Calcified Tissue International Springer US; http://www.springer-ny.com 96/1(2015-01-01), 38-44 0171-967X 96:1<38 2015 96 223 https://doi.org/10.1007/s00223-014-9936-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00223-014-9936-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Holloway Kara School of Medicine, Epi-Centre for Healthy Ageing, Deakin University, 285 Ryrie Street, PO Box 281, 3220, Geelong, VIC, Australia aut NATIONALLICENCE 700 1- Brennan Sharon School of Medicine, Epi-Centre for Healthy Ageing, Deakin University, 285 Ryrie Street, PO Box 281, 3220, Geelong, VIC, Australia aut NATIONALLICENCE 700 1- Kotowicz Mark School of Medicine, Epi-Centre for Healthy Ageing, Deakin University, 285 Ryrie Street, PO Box 281, 3220, Geelong, VIC, Australia aut NATIONALLICENCE 700 1- Bucki-Smith Gosia School of Medicine, Epi-Centre for Healthy Ageing, Deakin University, 285 Ryrie Street, PO Box 281, 3220, Geelong, VIC, Australia aut NATIONALLICENCE 700 1- Dobbins Amelia School of Medicine, Epi-Centre for Healthy Ageing, Deakin University, 285 Ryrie Street, PO Box 281, 3220, Geelong, VIC, Australia aut NATIONALLICENCE 700 1- Timney Elizabeth School of Medicine, Epi-Centre for Healthy Ageing, Deakin University, 285 Ryrie Street, PO Box 281, 3220, Geelong, VIC, Australia aut NATIONALLICENCE 700 1- Williams Lana School of Medicine, Epi-Centre for Healthy Ageing, Deakin University, 285 Ryrie Street, PO Box 281, 3220, Geelong, VIC, Australia aut NATIONALLICENCE 700 1- Pasco Julie School of Medicine, Epi-Centre for Healthy Ageing, Deakin University, 285 Ryrie Street, PO Box 281, 3220, Geelong, VIC, Australia aut NATIONALLICENCE 773 0- Calcified Tissue International Springer US; http://www.springer-ny.com 96/1(2015-01-01), 38-44 0171-967X 96:1<38 2015 96 223