caa a22 4500 605521107 CHVBK 20210128100738.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00223-014-9931-y doi (NATIONALLICENCE)springer-10.1007/s00223-014-9931-y Osteocalcin: An Osteoblast-Derived Polypeptide Hormone that Modulates Whole Body Energy Metabolism [Elektronische Daten] [Tara Brennan-Speranza, Arthur Conigrave] Osteocalcin is a bone-specific protein that is regularly used in the clinical setting as a serum marker of bone turnover. Recent evidence indicates that osteocalcin plays a previously unsuspected role in the control of energy metabolism. Thus, osteocalcin-deficient mice have a profoundly deranged metabolic phenotype that includes insulin resistance, glucose intolerance and abnormal fat deposition. Additionally, osteocalcin administration in mice improves insulin sensitivity and decreases fat pad mass and serum triglyceride levels. The role of osteocalcin in human macronutrient metabolism is less clear but recent studies report positive correlations between serum osteocalcin levels and established indices of metabolic health. Herein, we review key physiological functions of osteocalcin, focussing on the roles of osteocalcin in the modulation of macronutrient metabolism, male reproductive function and foetal brain development. We consider the implications of these findings for the coordination of metabolism with development and fertility. We also consider evidence that a Class C G-protein-coupled receptor from a subgroup known to mediate nutrient-sensing acts as the osteocalcin receptor. Springer Science+Business Media New York, 2014 Osteocalcin nationallicence Glucose tolerance nationallicence Energy metabolism nationallicence Brennan-Speranza Tara Discipline of Physiology & Bosch Institute, School of Medical Sciences, University of Sydney, 2006, Sydney, NSW, Australia aut Conigrave Arthur School of Molecular Bioscience, University of Sydney, 2006, Sydney, NSW, Australia aut Calcified Tissue International Springer US; http://www.springer-ny.com 96/1(2015-01-01), 1-10 0171-967X 96:1<1 2015 96 223 https://doi.org/10.1007/s00223-014-9931-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00223-014-9931-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Brennan-Speranza Tara Discipline of Physiology & Bosch Institute, School of Medical Sciences, University of Sydney, 2006, Sydney, NSW, Australia aut NATIONALLICENCE 700 1- Conigrave Arthur School of Molecular Bioscience, University of Sydney, 2006, Sydney, NSW, Australia aut NATIONALLICENCE 773 0- Calcified Tissue International Springer US; http://www.springer-ny.com 96/1(2015-01-01), 1-10 0171-967X 96:1<1 2015 96 223