Ibandronate Increases Sclerostin Levels and Bone Strength in Male Patients with Idiopathic Osteoporosis
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| 024 | 7 | 0 | |a 10.1007/s00223-015-0003-8 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00223-015-0003-8 | ||
| 245 | 0 | 0 | |a Ibandronate Increases Sclerostin Levels and Bone Strength in Male Patients with Idiopathic Osteoporosis |h [Elektronische Daten] |c [Christian Muschitz, Roland Kocijan, Dieter Pahr, Janina Patsch, Karin Amrein, Barbara Misof, Alexandra Kaider, Heinrich Resch, Peter Pietschmann] |
| 520 | 3 | |a The pathomechanism of male idiopathic osteoporosis (MIO) differs from postmenopausal osteoporosis with regard to alterations in osteoblast activity. We evaluated intravenous ibandronate (IBN) in 25 MIO patients with fragility fractures in a prospective, monocentric, single-arm, and open-label study for 24months. The impact and changes of sclerostin (Scl), Dickkopf-1 (DKK-1), CTX, and PINP were examined. Additionally, volumetric cortical, trabecular and areal bone mineral density (BMD), trabecular bone score (TBS), and finite element analyses (FEA) were evaluated. Compared to baseline, median Scl levels were increased after 1month (Δ 121%, p<0.0001) and remained elevated for 12months. DKK-1 decreased (p<0.001) to a lesser extent until month 9 with values comparable to baseline at study endpoint. Early changes (baseline-month 1) of Scl negatively correlated with early changes of DKK-1 (−0.72), CTX (−0.82), and PINP (−0.55; p<0.005 for all). The overall changes over the 24months study period of Scl negatively correlated with decreased CTX (−0.32) and DKK-1 levels (−0.57, p<0.0001 for both); CTX and PINP changes positively correlated at each time point (p<0.001). Volumetric hip BMD increased by 12 and 18%, respectively (p<0.0001 for both). Cross-sectional moment of inertia and section modulus for total hip significantly improved (p<0.05 for all). Areal BMD at total hip, spine, and TBS increased. FEA displayed an increase in bone strength both in the hip (17%) and vertebrae (13%, all p<0.0001) at anatomical sites susceptible for fragility fracture. IBN increases Scl and improves cortical and trabecular bone strength with early and ongoing vigorous suppression of bone resorption. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a Antiresorptive agents |2 nationallicence | |
| 690 | 7 | |a Ibandronate |2 nationallicence | |
| 690 | 7 | |a Male osteoporosis |2 nationallicence | |
| 690 | 7 | |a Sclerostin |2 nationallicence | |
| 690 | 7 | |a Bone turnover marker |2 nationallicence | |
| 690 | 7 | |a Finite element analysis |2 nationallicence | |
| 700 | 1 | |a Muschitz |D Christian |u Medical Department II, St. Vincent Hospital, Academic Teaching Hospital of the Medical University of Vienna, Stumpergasse 13, 1060, Vienna, Austria |4 aut | |
| 700 | 1 | |a Kocijan |D Roland |u Medical Department II, St. Vincent Hospital, Academic Teaching Hospital of the Medical University of Vienna, Stumpergasse 13, 1060, Vienna, Austria |4 aut | |
| 700 | 1 | |a Pahr |D Dieter |u Institute of Lightweight Design and Structural Biomechanics, University of Technology, Vienna, Austria |4 aut | |
| 700 | 1 | |a Patsch |D Janina |u Department of Diagnostic Radiology, Medical University of Vienna, Vienna, Austria |4 aut | |
| 700 | 1 | |a Amrein |D Karin |u Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical University of Graz, Graz, Austria |4 aut | |
| 700 | 1 | |a Misof |D Barbara |u Ludwig Boltzmann Institute of Osteology, Hanusch Hospital of WGKK and AUVA Trauma Center Meidling, 1st Medical Department, Hanusch Hospital, Vienna, Austria |4 aut | |
| 700 | 1 | |a Kaider |D Alexandra |u Center for Medical Statistics, Informatics and Intelligent Systems, Medical University of Vienna, Vienna, Austria |4 aut | |
| 700 | 1 | |a Resch |D Heinrich |u Medical Department II, St. Vincent Hospital, Academic Teaching Hospital of the Medical University of Vienna, Stumpergasse 13, 1060, Vienna, Austria |4 aut | |
| 700 | 1 | |a Pietschmann |D Peter |u Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria |4 aut | |
| 773 | 0 | |t Calcified Tissue International |d Springer US; http://www.springer-ny.com |g 96/6(2015-06-01), 477-489 |x 0171-967X |q 96:6<477 |1 2015 |2 96 |o 223 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00223-015-0003-8 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00223-015-0003-8 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Muschitz |D Christian |u Medical Department II, St. Vincent Hospital, Academic Teaching Hospital of the Medical University of Vienna, Stumpergasse 13, 1060, Vienna, Austria |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kocijan |D Roland |u Medical Department II, St. Vincent Hospital, Academic Teaching Hospital of the Medical University of Vienna, Stumpergasse 13, 1060, Vienna, Austria |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Pahr |D Dieter |u Institute of Lightweight Design and Structural Biomechanics, University of Technology, Vienna, Austria |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Patsch |D Janina |u Department of Diagnostic Radiology, Medical University of Vienna, Vienna, Austria |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Amrein |D Karin |u Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical University of Graz, Graz, Austria |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Misof |D Barbara |u Ludwig Boltzmann Institute of Osteology, Hanusch Hospital of WGKK and AUVA Trauma Center Meidling, 1st Medical Department, Hanusch Hospital, Vienna, Austria |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kaider |D Alexandra |u Center for Medical Statistics, Informatics and Intelligent Systems, Medical University of Vienna, Vienna, Austria |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Resch |D Heinrich |u Medical Department II, St. Vincent Hospital, Academic Teaching Hospital of the Medical University of Vienna, Stumpergasse 13, 1060, Vienna, Austria |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Pietschmann |D Peter |u Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Calcified Tissue International |d Springer US; http://www.springer-ny.com |g 96/6(2015-06-01), 477-489 |x 0171-967X |q 96:6<477 |1 2015 |2 96 |o 223 | ||