caa a22 4500 605521182 CHVBK 20210128100738.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s00223-015-0003-8 doi (NATIONALLICENCE)springer-10.1007/s00223-015-0003-8 Ibandronate Increases Sclerostin Levels and Bone Strength in Male Patients with Idiopathic Osteoporosis [Elektronische Daten] [Christian Muschitz, Roland Kocijan, Dieter Pahr, Janina Patsch, Karin Amrein, Barbara Misof, Alexandra Kaider, Heinrich Resch, Peter Pietschmann] The pathomechanism of male idiopathic osteoporosis (MIO) differs from postmenopausal osteoporosis with regard to alterations in osteoblast activity. We evaluated intravenous ibandronate (IBN) in 25 MIO patients with fragility fractures in a prospective, monocentric, single-arm, and open-label study for 24months. The impact and changes of sclerostin (Scl), Dickkopf-1 (DKK-1), CTX, and PINP were examined. Additionally, volumetric cortical, trabecular and areal bone mineral density (BMD), trabecular bone score (TBS), and finite element analyses (FEA) were evaluated. Compared to baseline, median Scl levels were increased after 1month (Δ 121%, p<0.0001) and remained elevated for 12months. DKK-1 decreased (p<0.001) to a lesser extent until month 9 with values comparable to baseline at study endpoint. Early changes (baseline-month 1) of Scl negatively correlated with early changes of DKK-1 (−0.72), CTX (−0.82), and PINP (−0.55; p<0.005 for all). The overall changes over the 24months study period of Scl negatively correlated with decreased CTX (−0.32) and DKK-1 levels (−0.57, p<0.0001 for both); CTX and PINP changes positively correlated at each time point (p<0.001). Volumetric hip BMD increased by 12 and 18%, respectively (p<0.0001 for both). Cross-sectional moment of inertia and section modulus for total hip significantly improved (p<0.05 for all). Areal BMD at total hip, spine, and TBS increased. FEA displayed an increase in bone strength both in the hip (17%) and vertebrae (13%, all p<0.0001) at anatomical sites susceptible for fragility fracture. IBN increases Scl and improves cortical and trabecular bone strength with early and ongoing vigorous suppression of bone resorption. Springer Science+Business Media New York, 2015 Antiresorptive agents nationallicence Ibandronate nationallicence Male osteoporosis nationallicence Sclerostin nationallicence Bone turnover marker nationallicence Finite element analysis nationallicence Muschitz Christian Medical Department II, St. Vincent Hospital, Academic Teaching Hospital of the Medical University of Vienna, Stumpergasse 13, 1060, Vienna, Austria aut Kocijan Roland Medical Department II, St. Vincent Hospital, Academic Teaching Hospital of the Medical University of Vienna, Stumpergasse 13, 1060, Vienna, Austria aut Pahr Dieter Institute of Lightweight Design and Structural Biomechanics, University of Technology, Vienna, Austria aut Patsch Janina Department of Diagnostic Radiology, Medical University of Vienna, Vienna, Austria aut Amrein Karin Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical University of Graz, Graz, Austria aut Misof Barbara Ludwig Boltzmann Institute of Osteology, Hanusch Hospital of WGKK and AUVA Trauma Center Meidling, 1st Medical Department, Hanusch Hospital, Vienna, Austria aut Kaider Alexandra Center for Medical Statistics, Informatics and Intelligent Systems, Medical University of Vienna, Vienna, Austria aut Resch Heinrich Medical Department II, St. Vincent Hospital, Academic Teaching Hospital of the Medical University of Vienna, Stumpergasse 13, 1060, Vienna, Austria aut Pietschmann Peter Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria aut Calcified Tissue International Springer US; http://www.springer-ny.com 96/6(2015-06-01), 477-489 0171-967X 96:6<477 2015 96 223 https://doi.org/10.1007/s00223-015-0003-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00223-015-0003-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Muschitz Christian Medical Department II, St. Vincent Hospital, Academic Teaching Hospital of the Medical University of Vienna, Stumpergasse 13, 1060, Vienna, Austria aut NATIONALLICENCE 700 1- Kocijan Roland Medical Department II, St. Vincent Hospital, Academic Teaching Hospital of the Medical University of Vienna, Stumpergasse 13, 1060, Vienna, Austria aut NATIONALLICENCE 700 1- Pahr Dieter Institute of Lightweight Design and Structural Biomechanics, University of Technology, Vienna, Austria aut NATIONALLICENCE 700 1- Patsch Janina Department of Diagnostic Radiology, Medical University of Vienna, Vienna, Austria aut NATIONALLICENCE 700 1- Amrein Karin Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical University of Graz, Graz, Austria aut NATIONALLICENCE 700 1- Misof Barbara Ludwig Boltzmann Institute of Osteology, Hanusch Hospital of WGKK and AUVA Trauma Center Meidling, 1st Medical Department, Hanusch Hospital, Vienna, Austria aut NATIONALLICENCE 700 1- Kaider Alexandra Center for Medical Statistics, Informatics and Intelligent Systems, Medical University of Vienna, Vienna, Austria aut NATIONALLICENCE 700 1- Resch Heinrich Medical Department II, St. Vincent Hospital, Academic Teaching Hospital of the Medical University of Vienna, Stumpergasse 13, 1060, Vienna, Austria aut NATIONALLICENCE 700 1- Pietschmann Peter Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria aut NATIONALLICENCE 773 0- Calcified Tissue International Springer US; http://www.springer-ny.com 96/6(2015-06-01), 477-489 0171-967X 96:6<477 2015 96 223