caa a22 4500 605521204 CHVBK 20210128100739.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s00223-015-9988-2 doi (NATIONALLICENCE)springer-10.1007/s00223-015-9988-2 Pediatric Reference Values for Tibial Trabecular Bone Mineral Density and Bone Geometry Parameters Using Peripheral Quantitative Computed Tomography [Elektronische Daten] [Inge Roggen, Mathieu Roelants, Isabelle Sioen, Sara Vandewalle, Stefaan De Henauw, Stefan Goemaere, Jean-Marc Kaufman, Jean De Schepper] The purpose of this study was to establish reference data, in relation to age and body height, for tibial trabecular and cortical volumetric bone mineral density, bone mineral content, and cross-sectional bone geometry in healthy children and adolescents using peripheral quantitative computed tomography (pQCT). Over a 2-year period, 432 (207 male and 225 female) healthy children, with an age range of 5 to 19years, from 6 different geographic areas in Belgium were recruited. Multislice pQCT scanning (XCT2000®, Stratec Medizintechnik, Pforzheim, Germany) was performed at the distal metaphysis (at the 4% site) and the distal diaphysis (14 and 38% sites) of the tibia of the dominant leg. Gender-specific centile curves in relation to age and body height were generated with the LMS method for total and trabecular volumetric bone mineral density (at 4% site), bone mineral content, total bone cross-sectional area, periosteal circumference (all at 4, 14, and 38% site), cortical volumetric bone mineral density, endosteal circumference, and cortical thickness (at the 14 and the 38% site). These centile curves can be used for the interpretation of pQCT results at the 4, 14, and 38% site of the tibia in European children and adolescents, at least when a similar methodology is used. Springer Science+Business Media New York, 2015 Reference values nationallicence Peripheral quantitative computed tomography nationallicence Tibia nationallicence Bone mineral density nationallicence Children nationallicence Adolescents nationallicence Roggen Inge Department of Pediatrics, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Laarbeeklaan 101, 1090, Brussels, Belgium aut Roelants Mathieu Laboratory of Anthropogenetics, Vrije Universiteit Brussel, Brussels, Belgium aut Sioen Isabelle Department of Public Health, Ghent University, Ghent, Belgium aut Vandewalle Sara Department of Endocrinology, UZ Gent, Ghent, Belgium aut De Henauw Stefaan Department of Public Health, Ghent University, Ghent, Belgium aut Goemaere Stefan Department of Endocrinology, UZ Gent, Ghent, Belgium aut Kaufman Jean-Marc Department of Endocrinology, UZ Gent, Ghent, Belgium aut De Schepper Jean Department of Pediatrics, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Laarbeeklaan 101, 1090, Brussels, Belgium aut Calcified Tissue International Springer US; http://www.springer-ny.com 96/6(2015-06-01), 527-533 0171-967X 96:6<527 2015 96 223 https://doi.org/10.1007/s00223-015-9988-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00223-015-9988-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Roggen Inge Department of Pediatrics, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Laarbeeklaan 101, 1090, Brussels, Belgium aut NATIONALLICENCE 700 1- Roelants Mathieu Laboratory of Anthropogenetics, Vrije Universiteit Brussel, Brussels, Belgium aut NATIONALLICENCE 700 1- Sioen Isabelle Department of Public Health, Ghent University, Ghent, Belgium aut NATIONALLICENCE 700 1- Vandewalle Sara Department of Endocrinology, UZ Gent, Ghent, Belgium aut NATIONALLICENCE 700 1- De Henauw Stefaan Department of Public Health, Ghent University, Ghent, Belgium aut NATIONALLICENCE 700 1- Goemaere Stefan Department of Endocrinology, UZ Gent, Ghent, Belgium aut NATIONALLICENCE 700 1- Kaufman Jean-Marc Department of Endocrinology, UZ Gent, Ghent, Belgium aut NATIONALLICENCE 700 1- De Schepper Jean Department of Pediatrics, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Laarbeeklaan 101, 1090, Brussels, Belgium aut NATIONALLICENCE 773 0- Calcified Tissue International Springer US; http://www.springer-ny.com 96/6(2015-06-01), 527-533 0171-967X 96:6<527 2015 96 223