The Effects of Atorvastatin on the Prevention of Osteoporosis and Dyslipidemia in the High-Fat-Fed Ovariectomized Rats
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| 024 | 7 | 0 | |a 10.1007/s00223-015-9975-7 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00223-015-9975-7 | ||
| 245 | 0 | 4 | |a The Effects of Atorvastatin on the Prevention of Osteoporosis and Dyslipidemia in the High-Fat-Fed Ovariectomized Rats |h [Elektronische Daten] |c [Sien Lin, Jianping Huang, Ziwei Fu, Yanlong Liang, Haiyou Wu, Liangliang Xu, Yuxin Sun, Wayne Lee, Tie Wu, Ling Qin, Liao Cui, Gang Li] |
| 520 | 3 | |a Previous studies reported that statins showed positive effects on bone in both human and animal models. This study aimed to investigate the effects of atorvastatin on the prevention of osteoporosis and dyslipidemia in ovariectomized rats fed with high-fat emulsion. The 3-month-old female rats were subjected to either sham operations (n=8) or ovariectomized operations (OVX, n=24). The OVX rats were orally administered deionized water (n=8) or standardized high-fat emulsion without (n=8) or with atorvastatin (n=8). All rats were injected twice with calcein before sacrificed for the purpose of double in vivo labeling. After 12weeks, all rats were sacrificed under anesthesia. Biochemistry, histomorphometry, mechanical test, micro-computed tomography analysis, mechanical test, histology, and component analysis were performed. We found that high-fat emulsion significantly decreased body weight, bone formation, collagen content of bone, and bone biomechanics, while increased blood, liver, and bone marrow lipids. Atorvastatin treatment prevented dyslipidemia, reversed hepatic steatosis, optimized composition of bone, and improved bone mechanical properties. The current study provided further evidence that atorvastatin might be useful for the treatment of osteoporotic patients with dyslipidemia. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a Ovariectomy |2 nationallicence | |
| 690 | 7 | |a Osteoporosis |2 nationallicence | |
| 690 | 7 | |a Dyslipidemia |2 nationallicence | |
| 690 | 7 | |a Rat |2 nationallicence | |
| 690 | 7 | |a Atorvastatin |2 nationallicence | |
| 700 | 1 | |a Lin |D Sien |u Department of Pharmacology, Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical College, 524023, Zhanjiang, Guangdong, China |4 aut | |
| 700 | 1 | |a Huang |D Jianping |u Department of Stomatology, Guangdong Medical College, Zhanjiang, Guangdong, China |4 aut | |
| 700 | 1 | |a Fu |D Ziwei |u Department of Pharmacology, Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical College, 524023, Zhanjiang, Guangdong, China |4 aut | |
| 700 | 1 | |a Liang |D Yanlong |u Department of Pharmacology, Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical College, 524023, Zhanjiang, Guangdong, China |4 aut | |
| 700 | 1 | |a Wu |D Haiyou |u Department of Pharmacology, Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical College, 524023, Zhanjiang, Guangdong, China |4 aut | |
| 700 | 1 | |a Xu |D Liangliang |u Department of Orthopaedics and Traumatology and Li Ka Shing Institute of Health Sciences, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, China |4 aut | |
| 700 | 1 | |a Sun |D Yuxin |u Department of Orthopaedics and Traumatology and Li Ka Shing Institute of Health Sciences, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, China |4 aut | |
| 700 | 1 | |a Lee |D Wayne |u Department of Orthopaedics and Traumatology and Li Ka Shing Institute of Health Sciences, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, China |4 aut | |
| 700 | 1 | |a Wu |D Tie |u Department of Pharmacology, Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical College, 524023, Zhanjiang, Guangdong, China |4 aut | |
| 700 | 1 | |a Qin |D Ling |u Department of Orthopaedics and Traumatology and Li Ka Shing Institute of Health Sciences, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, China |4 aut | |
| 700 | 1 | |a Cui |D Liao |u Department of Pharmacology, Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical College, 524023, Zhanjiang, Guangdong, China |4 aut | |
| 700 | 1 | |a Li |D Gang |u Department of Orthopaedics and Traumatology and Li Ka Shing Institute of Health Sciences, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, China |4 aut | |
| 773 | 0 | |t Calcified Tissue International |d Springer US; http://www.springer-ny.com |g 96/6(2015-06-01), 541-551 |x 0171-967X |q 96:6<541 |1 2015 |2 96 |o 223 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00223-015-9975-7 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00223-015-9975-7 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Lin |D Sien |u Department of Pharmacology, Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical College, 524023, Zhanjiang, Guangdong, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Huang |D Jianping |u Department of Stomatology, Guangdong Medical College, Zhanjiang, Guangdong, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Fu |D Ziwei |u Department of Pharmacology, Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical College, 524023, Zhanjiang, Guangdong, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Liang |D Yanlong |u Department of Pharmacology, Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical College, 524023, Zhanjiang, Guangdong, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Wu |D Haiyou |u Department of Pharmacology, Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical College, 524023, Zhanjiang, Guangdong, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Xu |D Liangliang |u Department of Orthopaedics and Traumatology and Li Ka Shing Institute of Health Sciences, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sun |D Yuxin |u Department of Orthopaedics and Traumatology and Li Ka Shing Institute of Health Sciences, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Lee |D Wayne |u Department of Orthopaedics and Traumatology and Li Ka Shing Institute of Health Sciences, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Wu |D Tie |u Department of Pharmacology, Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical College, 524023, Zhanjiang, Guangdong, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Qin |D Ling |u Department of Orthopaedics and Traumatology and Li Ka Shing Institute of Health Sciences, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Cui |D Liao |u Department of Pharmacology, Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical College, 524023, Zhanjiang, Guangdong, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Li |D Gang |u Department of Orthopaedics and Traumatology and Li Ka Shing Institute of Health Sciences, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Calcified Tissue International |d Springer US; http://www.springer-ny.com |g 96/6(2015-06-01), 541-551 |x 0171-967X |q 96:6<541 |1 2015 |2 96 |o 223 | ||