caa a22 4500 605521220 CHVBK 20210128100739.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s00223-015-9975-7 doi (NATIONALLICENCE)springer-10.1007/s00223-015-9975-7 The Effects of Atorvastatin on the Prevention of Osteoporosis and Dyslipidemia in the High-Fat-Fed Ovariectomized Rats [Elektronische Daten] [Sien Lin, Jianping Huang, Ziwei Fu, Yanlong Liang, Haiyou Wu, Liangliang Xu, Yuxin Sun, Wayne Lee, Tie Wu, Ling Qin, Liao Cui, Gang Li] Previous studies reported that statins showed positive effects on bone in both human and animal models. This study aimed to investigate the effects of atorvastatin on the prevention of osteoporosis and dyslipidemia in ovariectomized rats fed with high-fat emulsion. The 3-month-old female rats were subjected to either sham operations (n=8) or ovariectomized operations (OVX, n=24). The OVX rats were orally administered deionized water (n=8) or standardized high-fat emulsion without (n=8) or with atorvastatin (n=8). All rats were injected twice with calcein before sacrificed for the purpose of double in vivo labeling. After 12weeks, all rats were sacrificed under anesthesia. Biochemistry, histomorphometry, mechanical test, micro-computed tomography analysis, mechanical test, histology, and component analysis were performed. We found that high-fat emulsion significantly decreased body weight, bone formation, collagen content of bone, and bone biomechanics, while increased blood, liver, and bone marrow lipids. Atorvastatin treatment prevented dyslipidemia, reversed hepatic steatosis, optimized composition of bone, and improved bone mechanical properties. The current study provided further evidence that atorvastatin might be useful for the treatment of osteoporotic patients with dyslipidemia. Springer Science+Business Media New York, 2015 Ovariectomy nationallicence Osteoporosis nationallicence Dyslipidemia nationallicence Rat nationallicence Atorvastatin nationallicence Lin Sien Department of Pharmacology, Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical College, 524023, Zhanjiang, Guangdong, China aut Huang Jianping Department of Stomatology, Guangdong Medical College, Zhanjiang, Guangdong, China aut Fu Ziwei Department of Pharmacology, Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical College, 524023, Zhanjiang, Guangdong, China aut Liang Yanlong Department of Pharmacology, Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical College, 524023, Zhanjiang, Guangdong, China aut Wu Haiyou Department of Pharmacology, Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical College, 524023, Zhanjiang, Guangdong, China aut Xu Liangliang Department of Orthopaedics and Traumatology and Li Ka Shing Institute of Health Sciences, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, China aut Sun Yuxin Department of Orthopaedics and Traumatology and Li Ka Shing Institute of Health Sciences, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, China aut Lee Wayne Department of Orthopaedics and Traumatology and Li Ka Shing Institute of Health Sciences, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, China aut Wu Tie Department of Pharmacology, Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical College, 524023, Zhanjiang, Guangdong, China aut Qin Ling Department of Orthopaedics and Traumatology and Li Ka Shing Institute of Health Sciences, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, China aut Cui Liao Department of Pharmacology, Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical College, 524023, Zhanjiang, Guangdong, China aut Li Gang Department of Orthopaedics and Traumatology and Li Ka Shing Institute of Health Sciences, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, China aut Calcified Tissue International Springer US; http://www.springer-ny.com 96/6(2015-06-01), 541-551 0171-967X 96:6<541 2015 96 223 https://doi.org/10.1007/s00223-015-9975-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00223-015-9975-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lin Sien Department of Pharmacology, Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical College, 524023, Zhanjiang, Guangdong, China aut NATIONALLICENCE 700 1- Huang Jianping Department of Stomatology, Guangdong Medical College, Zhanjiang, Guangdong, China aut NATIONALLICENCE 700 1- Fu Ziwei Department of Pharmacology, Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical College, 524023, Zhanjiang, Guangdong, China aut NATIONALLICENCE 700 1- Liang Yanlong Department of Pharmacology, Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical College, 524023, Zhanjiang, Guangdong, China aut NATIONALLICENCE 700 1- Wu Haiyou Department of Pharmacology, Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical College, 524023, Zhanjiang, Guangdong, China aut NATIONALLICENCE 700 1- Xu Liangliang Department of Orthopaedics and Traumatology and Li Ka Shing Institute of Health Sciences, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, China aut NATIONALLICENCE 700 1- Sun Yuxin Department of Orthopaedics and Traumatology and Li Ka Shing Institute of Health Sciences, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, China aut NATIONALLICENCE 700 1- Lee Wayne Department of Orthopaedics and Traumatology and Li Ka Shing Institute of Health Sciences, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, China aut NATIONALLICENCE 700 1- Wu Tie Department of Pharmacology, Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical College, 524023, Zhanjiang, Guangdong, China aut NATIONALLICENCE 700 1- Qin Ling Department of Orthopaedics and Traumatology and Li Ka Shing Institute of Health Sciences, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, China aut NATIONALLICENCE 700 1- Cui Liao Department of Pharmacology, Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical College, 524023, Zhanjiang, Guangdong, China aut NATIONALLICENCE 700 1- Li Gang Department of Orthopaedics and Traumatology and Li Ka Shing Institute of Health Sciences, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, China aut NATIONALLICENCE 773 0- Calcified Tissue International Springer US; http://www.springer-ny.com 96/6(2015-06-01), 541-551 0171-967X 96:6<541 2015 96 223