caa a22 4500 605521247 CHVBK 20210128100739.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s00223-015-0004-7 doi (NATIONALLICENCE)springer-10.1007/s00223-015-0004-7 Systemic Administration of Lithium Improves Distracted Bone Regeneration in Rats [Elektronische Daten] [Xuemei Wang, Songsong Zhu, Xiaowen Jiang, Yunfeng Li, Donghui Song, Jing Hu] Lithium, popular in psychology field, has been recognized as an activator component of the canonical Wnt signaling pathway. The effect of lithium on osteogenesis or on the human fracture risk has been widely reported. However, little is known on its role in distraction osteogenesis to date. In this study, the effect of systematic administrated lithium on distraction osteogenesis in a rat model was investigated. The osteotomy was performed on the right tibia in 40 adult male Sprague-Dawley rats. Then they were randomly assigned into two equal groups (n=20/group), which underwent Lithium or saline treatment through gastric gavage until the day they were killed. One week after the osteotomy, the tibias were distracted for 14days (rate 0.6mm/day). Following 8weeks consolidation period, the distracted tibias in both groups were harvested and examined by X-ray plain radiography, histology, dual-energy X-ray absorptiometry, Micro-CT, and biomechanical tests. The results showed that lithium group possessed higher bone mineral density, more mature new bone tissue, and better regenerated bone mass continuity in the distraction gaps without any local or systemic adverse effects was encountered. This study suggested lithium could increase bony callus ossification volume and accelerate distracted tissue mineralization to facilitate bone regeneration in distraction gap. Springer Science+Business Media New York, 2015 Lithium nationallicence Distraction osteogenesis nationallicence Limb lengthening nationallicence Bone regeneration nationallicence Wang Xuemei The State Key Laboratory of Oral Diseases and Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, China aut Zhu Songsong The State Key Laboratory of Oral Diseases and Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, China aut Jiang Xiaowen The State Key Laboratory of Oral Diseases and Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, China aut Li Yunfeng The State Key Laboratory of Oral Diseases and Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, China aut Song Donghui The State Key Laboratory of Oral Diseases and Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, China aut Hu Jing The State Key Laboratory of Oral Diseases and Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, China aut Calcified Tissue International Springer US; http://www.springer-ny.com 96/6(2015-06-01), 534-540 0171-967X 96:6<534 2015 96 223 https://doi.org/10.1007/s00223-015-0004-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00223-015-0004-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wang Xuemei The State Key Laboratory of Oral Diseases and Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, China aut NATIONALLICENCE 700 1- Zhu Songsong The State Key Laboratory of Oral Diseases and Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, China aut NATIONALLICENCE 700 1- Jiang Xiaowen The State Key Laboratory of Oral Diseases and Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, China aut NATIONALLICENCE 700 1- Li Yunfeng The State Key Laboratory of Oral Diseases and Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, China aut NATIONALLICENCE 700 1- Song Donghui The State Key Laboratory of Oral Diseases and Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, China aut NATIONALLICENCE 700 1- Hu Jing The State Key Laboratory of Oral Diseases and Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, China aut NATIONALLICENCE 773 0- Calcified Tissue International Springer US; http://www.springer-ny.com 96/6(2015-06-01), 534-540 0171-967X 96:6<534 2015 96 223