caa a22 4500 605521263 CHVBK 20210128100739.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s00223-014-9924-x doi (NATIONALLICENCE)springer-10.1007/s00223-014-9924-x Estrogen Influences on Neuromuscular Function in Postmenopausal Women [Elektronische Daten] [S. Sipilä, T. Finni, V. Kovanen] Exposure to ovarian sex steroids during different life phases has long-term effects on women's health and wellbeing. Menopause is characterized by rapid decline in ovarian sex steroids already during mid-life, between the ages of 46 and 52. Due to the menopause-related hormonal changes, women in most western countries live more than one-third of their lives in postmenopausal status. The role of ovarian steroids on neuromuscular function in middle-aged and older women has been investigated since the 1980s with increasing volume of research during the last decades. This review considers how different components of the neuromuscular system may be influenced by estrogens and so affects neuromuscular function in postmenopausal women. The main focus is on muscle strength and power, which are closely associated with mobility and functional capacity among older populations. In the end of the review, we summarize recent findings on the underlying biological mechanisms in skeletal muscle that could explain the association between hormone replacement therapy and neuromuscular function among postmenopausal women. Springer Science+Business Media New York, 2014 Aging nationallicence Muscle strength nationallicence Hormone replacement therapy nationallicence IGF-1 pathway nationallicence MicroRNA nationallicence Myosin-actin cross-bridges nationallicence Sipilä S. Department of Health Sciences, Gerontology Research Center, University of Jyväskylä, Jyväskylä, Finland aut Finni T. Department of Biology of Physical Activity, Neuromuscular Research Center, University of Jyväskylä, Jyväskylä, Finland aut Kovanen V. Department of Health Sciences, Gerontology Research Center, University of Jyväskylä, Jyväskylä, Finland aut Calcified Tissue International Springer US; http://www.springer-ny.com 96/3(2015-03-01), 222-233 0171-967X 96:3<222 2015 96 223 https://doi.org/10.1007/s00223-014-9924-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00223-014-9924-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sipilä S. Department of Health Sciences, Gerontology Research Center, University of Jyväskylä, Jyväskylä, Finland aut NATIONALLICENCE 700 1- Finni T. Department of Biology of Physical Activity, Neuromuscular Research Center, University of Jyväskylä, Jyväskylä, Finland aut NATIONALLICENCE 700 1- Kovanen V. Department of Health Sciences, Gerontology Research Center, University of Jyväskylä, Jyväskylä, Finland aut NATIONALLICENCE 773 0- Calcified Tissue International Springer US; http://www.springer-ny.com 96/3(2015-03-01), 222-233 0171-967X 96:3<222 2015 96 223