caa a22 4500 605521271 CHVBK 20210128100739.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s00223-014-9915-y doi (NATIONALLICENCE)springer-10.1007/s00223-014-9915-y Skeletal Muscle: A Brief Review of Structure and Function [Elektronische Daten] [Walter Frontera, Julien Ochala] Skeletal muscle is one of the most dynamic and plastic tissues of the human body. In humans, skeletal muscle comprises approximately 40% of total body weight and contains 50-75% of all body proteins. In general, muscle mass depends on the balance between protein synthesis and degradation and both processes are sensitive to factors such as nutritional status, hormonal balance, physical activity/exercise, and injury or disease, among others. In this review, we discuss the various domains of muscle structure and function including its cytoskeletal architecture, excitation-contraction coupling, energy metabolism, and force and power generation. We will limit the discussion to human skeletal muscle and emphasize recent scientific literature on single muscle fibers. Springer Science+Business Media New York, 2014 Muscle actions nationallicence Metabolism nationallicence Force generation nationallicence Exercise nationallicence Sarcopenia nationallicence Dystrophy nationallicence Frontera Walter Department of Physical Medicine and Rehabilitation, Vanderbilt University School of Medicine, Suite 1318, 2201 Children's Way, 37212, Nashville, TN, USA aut Ochala Julien Department of Human and Aerospace Physiological Sciences, King's College London, London, UK aut Calcified Tissue International Springer US; http://www.springer-ny.com 96/3(2015-03-01), 183-195 0171-967X 96:3<183 2015 96 223 https://doi.org/10.1007/s00223-014-9915-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00223-014-9915-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Frontera Walter Department of Physical Medicine and Rehabilitation, Vanderbilt University School of Medicine, Suite 1318, 2201 Children's Way, 37212, Nashville, TN, USA aut NATIONALLICENCE 700 1- Ochala Julien Department of Human and Aerospace Physiological Sciences, King's College London, London, UK aut NATIONALLICENCE 773 0- Calcified Tissue International Springer US; http://www.springer-ny.com 96/3(2015-03-01), 183-195 0171-967X 96:3<183 2015 96 223