caa a22 4500 60552128X CHVBK 20210128100739.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s00223-014-9921-0 doi (NATIONALLICENCE)springer-10.1007/s00223-014-9921-0 Implications of Exercise Training and Distribution of Protein Intake on Molecular Processes Regulating Skeletal Muscle Plasticity [Elektronische Daten] [Lee Margolis, Donato Rivas] To optimize its function, skeletal muscle exhibits exceptional plasticity and possesses the fundamental capacity to adapt its metabolic and contractile properties in response to various external stimuli (e.g., external loading, nutrient availability, and humoral factors). The adaptability of skeletal muscle, along with its relatively large mass and high metabolic rate, makes this tissue an important contributor to whole body health and mobility. This adaptational process includes changes in the number, size, and structural/functional properties of the myofibers. The adaptations of skeletal muscle to exercise are highly interrelated with dietary intake, particularly dietary protein, which has been shown to further potentiate exercise training-induced adaptations. Understanding the molecular adaptation of skeletal muscle to exercise and protein consumption is vital to elicit maximum benefit from exercise training to improve human performance and health. In this review, we will provide an overview of the molecular pathways regulating skeletal muscle adaptation to exercise and protein, and discuss the role of subsequent timing of nutrient intake following exercise. Springer Science+Business Media New York, 2014 Skeletal muscle nationallicence Exercise adaptation nationallicence Mitochondrial biogenesis nationallicence Muscle protein turnover nationallicence Dietary protein nationallicence Cellular signaling nationallicence Margolis Lee Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center On Aging, Tufts University, 711 Washington Street, 02111, Boston, MA, USA aut Rivas Donato Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center On Aging, Tufts University, 711 Washington Street, 02111, Boston, MA, USA aut Calcified Tissue International Springer US; http://www.springer-ny.com 96/3(2015-03-01), 211-221 0171-967X 96:3<211 2015 96 223 https://doi.org/10.1007/s00223-014-9921-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00223-014-9921-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Margolis Lee Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center On Aging, Tufts University, 711 Washington Street, 02111, Boston, MA, USA aut NATIONALLICENCE 700 1- Rivas Donato Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center On Aging, Tufts University, 711 Washington Street, 02111, Boston, MA, USA aut NATIONALLICENCE 773 0- Calcified Tissue International Springer US; http://www.springer-ny.com 96/3(2015-03-01), 211-221 0171-967X 96:3<211 2015 96 223