caa a22 4500 605521328 CHVBK 20210128100739.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s00223-015-9956-x doi (NATIONALLICENCE)springer-10.1007/s00223-015-9956-x Girgis Christian Westmead Millennium Institute for Medical Research, 176 Hawkesbury Rd, Westmead, NSW, Australia aut Integrated Therapies for Osteoporosis and Sarcopenia: From Signaling Pathways to Clinical Trials [Elektronische Daten] [Christian Girgis] Sarcopenia and osteoporosis are two sides of the same coin. They represent different aspects of the same age-related process of musculoskeletal atrophy and together culminate in falls, fractures, deconditioning, and increased mortality in older individuals. However, the current therapeutic approach to the prevention of minimal trauma fracture is unilateral and focuses solely on bone. In theory, an integrated approach that recognizes the interaction between muscle and bone could break the vicious cycle of their combined involution and more effectively minimize falls/fractures. In this review, signaling pathways and cross-talk mechanisms that integrate bone/muscle, and the emergence of novel therapies that exploit these pathways to target osteoporosis/sarcopenia will be discussed. In broad terms, these agents act on nuclear receptors (e.g., VDR, AR) or transmembrane receptors (e.g., activins, GH/IGF-1) expressed in muscle and bone, and seek to alter biologic responses to musculoskeletal aging, loading, and injury. Challenges in the development of these dual bone-muscle therapies, early clinical trials examining their safety/efficacy, and novel targets that hold promise in the reversal of musculoskeletal aging will be discussed. Springer Science+Business Media New York, 2015 Sarcopenia nationallicence Osteoporosis nationallicence Aging nationallicence Anabolic nationallicence Musculoskeletal nationallicence Bone-muscle cross-talk nationallicence Calcified Tissue International Springer US; http://www.springer-ny.com 96/3(2015-03-01), 243-255 0171-967X 96:3<243 2015 96 223 https://doi.org/10.1007/s00223-015-9956-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00223-015-9956-x text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Girgis Christian Westmead Millennium Institute for Medical Research, 176 Hawkesbury Rd, Westmead, NSW, Australia aut NATIONALLICENCE 773 0- Calcified Tissue International Springer US; http://www.springer-ny.com 96/3(2015-03-01), 243-255 0171-967X 96:3<243 2015 96 223