caa a22 4500 605521336 CHVBK 20210128100739.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s00223-015-9960-1 doi (NATIONALLICENCE)springer-10.1007/s00223-015-9960-1 Reliability of Vertebral Fractures Assessment (VFA) in Children with Osteogenesis Imperfecta [Elektronische Daten] [D. Diacinti, D. Pisani, M. D'Avanzo, M. Celli, A. Zambrano, M. Stoppo, Davide Diacinti, M. Roggini, F. Todde, P. D'Eufemia, Jessica Pepe, S. Minisola] The aim of this study is to evaluate the diagnostic accuracy of vertebral fractures assessment (VFA) in comparison with conventional radiography in identifying vertebral fractures in children and adolescents affected by OI. On 58 patients (33 males, 25 females; age range 1-18years; 41 children and 17 adolescents) with osteogenesis imperfecta (OI type I, n=44, OI type III, n=4; OI type IV, n=10), lateral spine images by radiographs and by dual-energy X-ray absorptiometry (DXA) were acquired. For vertebral fracture diagnosis, plain radiographs were used as "gold standard” and VFA and morphometric X-ray absorptiometry (MXA) were performed. The visualized vertebrae were 738 (97.9%) by radiographs and 685 (90.9%) by DXA of a total of 754 vertebrae from T4 to L4. VFA and MXA identified, respectively, 129 (74%) and 116 (66%) of the 175 vertebral fractures detected by radiographs. Radiographs identified 36 patients with vertebral fractures, VFA 35 and MXA 41 (6 false positives). On a per vertebra basis, radiographs and VFA had elevated agreement (93.9%; k score 0.81, 95% CI 0.76-0.86), that resulted slightly lower for MXA (90.6%; k score 0.72, 95% CI 0.65-0.78). VFA and MXA demonstrated high sensitivity (95.6 and 94.1 %, respectively) while specificity was 100% for VFA and 90.6% for MXA on a per patient basis; the agreement was excellent for VFA (98.3%; k score 0.96, 95% CI 0.89-1.03) and good for MXA (87.9%; k score 0.73, 95% CI 0.55-0.91). The diagnostic performance parameters resulted better for VFA (sensitivity 95.6%; specificity 100%; PPV 100%; NPV 97.2%), than for MXA (sensitivity 94.1%; specificity 85.4%; PPV 72.7%; NPV 97.2%). The results of our study demonstrate the reliability of VFA for diagnosis of vertebral fractures in children with OI suggesting its use as a more safe and practical alternative to conventional radiography. Springer Science+Business Media New York, 2015 DXA nationallicence VFA nationallicence Osteogenesis imperfecta nationallicence Vertebral fractures nationallicence Children nationallicence Diacinti D. Department of Radiology, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy aut Pisani D. Department of Clinical and Molecular Medicine, Sant' Andrea Hospital, Sapienza University of Rome, Via Grottarossa 1035, 00189, Rome, Italy aut D'Avanzo M. Department of Radiology, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy aut Celli M. Department of Pediatrics, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy aut Zambrano A. Department of Pediatrics, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy aut Stoppo M. Department of Clinical and Molecular Medicine, Sant' Andrea Hospital, Sapienza University of Rome, Via Grottarossa 1035, 00189, Rome, Italy aut Diacinti Davide Department of Radiology, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy aut Roggini M. Department of Radiology, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy aut Todde F. Department of Clinical and Molecular Medicine, Sant' Andrea Hospital, Sapienza University of Rome, Via Grottarossa 1035, 00189, Rome, Italy aut D'Eufemia P. Department of Pediatrics, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy aut Pepe Jessica Department of Clinical Sciences, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy aut Minisola S. Department of Clinical Sciences, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy aut Calcified Tissue International Springer US; http://www.springer-ny.com 96/4(2015-04-01), 307-312 0171-967X 96:4<307 2015 96 223 https://doi.org/10.1007/s00223-015-9960-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00223-015-9960-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Diacinti D. Department of Radiology, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy aut NATIONALLICENCE 700 1- Pisani D. Department of Clinical and Molecular Medicine, Sant' Andrea Hospital, Sapienza University of Rome, Via Grottarossa 1035, 00189, Rome, Italy aut NATIONALLICENCE 700 1- D'Avanzo M. Department of Radiology, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy aut NATIONALLICENCE 700 1- Celli M. Department of Pediatrics, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy aut NATIONALLICENCE 700 1- Zambrano A. Department of Pediatrics, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy aut NATIONALLICENCE 700 1- Stoppo M. Department of Clinical and Molecular Medicine, Sant' Andrea Hospital, Sapienza University of Rome, Via Grottarossa 1035, 00189, Rome, Italy aut NATIONALLICENCE 700 1- Diacinti Davide Department of Radiology, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy aut NATIONALLICENCE 700 1- Roggini M. Department of Radiology, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy aut NATIONALLICENCE 700 1- Todde F. Department of Clinical and Molecular Medicine, Sant' Andrea Hospital, Sapienza University of Rome, Via Grottarossa 1035, 00189, Rome, Italy aut NATIONALLICENCE 700 1- D'Eufemia P. Department of Pediatrics, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy aut NATIONALLICENCE 700 1- Pepe Jessica Department of Clinical Sciences, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy aut NATIONALLICENCE 700 1- Minisola S. Department of Clinical Sciences, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy aut NATIONALLICENCE 773 0- Calcified Tissue International Springer US; http://www.springer-ny.com 96/4(2015-04-01), 307-312 0171-967X 96:4<307 2015 96 223