A Pediatric Bone Mass Scan has Poor Ability to Predict Peak Bone Mass: An 11-Year Prospective Study in 121 Children
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| 024 | 7 | 0 | |a 10.1007/s00223-015-9965-9 |2 doi |
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| 245 | 0 | 2 | |a A Pediatric Bone Mass Scan has Poor Ability to Predict Peak Bone Mass: An 11-Year Prospective Study in 121 Children |h [Elektronische Daten] |c [Christian Buttazzoni, Bjorn Rosengren, Caroline Karlsson, Magnus Dencker, Jan-Åke Nilsson, Magnus Karlsson] |
| 520 | 3 | |a This 11-year prospective longitudinal study examined how a pre-pubertal pediatric bone mass scan predicts peak bone mass. We measured bone mineral content (BMC; g), bone mineral density (BMD; g/cm2), and bone area (cm2) in femoral neck, total body and lumbar spine by dual-energy X-ray absorptiometry in a population-based cohort including 65 boys and 56 girls. At baseline all participants were pre-pubertal with a mean age of 8years (range 6-9), they were re-measured at a mean 11years (range 10-12) later. The participants were then mean 19years (range 18-19), an age range that corresponds to peak bone mass in femoral neck in our population. We calculated individual BMC, BMD, and bone size Z scores, using all participants at each measurement as reference and evaluated correlations between the two measurements. Individual Z scores were also stratified in quartiles to register movements between quartiles from pre-pubertal age to peak bone mass. The correlation coefficients (r) between pre-pubertal and young adulthood measurements for femoral neck BMC, BMD, and bone area varied between 0.37 and 0.65. The reached BMC value at age 8years explained 42% of the variance in the BMC peak value; the corresponding values for BMD were 31% and bone area 14%. Among the participants with femoral neck BMD in the lowest childhood quartile, 52% had left this quartile at peak bone mass. A pediatric bone scan with a femoral neck BMD value in the lowest quartile had a sensitivity of 47% [95% confidence interval (CI) 28, 66] and a specificity of 82% (95% CI 72, 89) to identify individuals who would remain in the lowest quartile at peak bone mass. The pre-pubertal femoral neck BMD explained only 31% of the variance in femoral neck peak bone mass. A pre-pubertal BMD scan in a population-based sample has poor ability to predict individuals who are at risk of low peak bone mass. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a Adult |2 nationallicence | |
| 690 | 7 | |a BMD |2 nationallicence | |
| 690 | 7 | |a BMC |2 nationallicence | |
| 690 | 7 | |a Bone mass |2 nationallicence | |
| 690 | 7 | |a Child |2 nationallicence | |
| 690 | 7 | |a Growth |2 nationallicence | |
| 690 | 7 | |a Peak bone mass |2 nationallicence | |
| 700 | 1 | |a Buttazzoni |D Christian |u Clinical and Molecular Osteoporosis Research Unit, Department of Orthopedics and Clinical Sciences, Skåne University Hospital, Lund University, 205 02, Malmō, Sweden |4 aut | |
| 700 | 1 | |a Rosengren |D Bjorn |u Clinical and Molecular Osteoporosis Research Unit, Department of Orthopedics and Clinical Sciences, Skåne University Hospital, Lund University, 205 02, Malmō, Sweden |4 aut | |
| 700 | 1 | |a Karlsson |D Caroline |u Clinical and Molecular Osteoporosis Research Unit, Department of Orthopedics and Clinical Sciences, Skåne University Hospital, Lund University, 205 02, Malmō, Sweden |4 aut | |
| 700 | 1 | |a Dencker |D Magnus |u Clinical and Molecular Osteoporosis Research Unit, Department of Orthopedics and Clinical Sciences, Skåne University Hospital, Lund University, 205 02, Malmō, Sweden |4 aut | |
| 700 | 1 | |a Nilsson |D Jan-Åke |u Clinical and Molecular Osteoporosis Research Unit, Department of Orthopedics and Clinical Sciences, Skåne University Hospital, Lund University, 205 02, Malmō, Sweden |4 aut | |
| 700 | 1 | |a Karlsson |D Magnus |u Clinical and Molecular Osteoporosis Research Unit, Department of Orthopedics and Clinical Sciences, Skåne University Hospital, Lund University, 205 02, Malmō, Sweden |4 aut | |
| 773 | 0 | |t Calcified Tissue International |d Springer US; http://www.springer-ny.com |g 96/5(2015-05-01), 379-388 |x 0171-967X |q 96:5<379 |1 2015 |2 96 |o 223 | |
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00223-015-9965-9 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Buttazzoni |D Christian |u Clinical and Molecular Osteoporosis Research Unit, Department of Orthopedics and Clinical Sciences, Skåne University Hospital, Lund University, 205 02, Malmō, Sweden |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Rosengren |D Bjorn |u Clinical and Molecular Osteoporosis Research Unit, Department of Orthopedics and Clinical Sciences, Skåne University Hospital, Lund University, 205 02, Malmō, Sweden |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Karlsson |D Caroline |u Clinical and Molecular Osteoporosis Research Unit, Department of Orthopedics and Clinical Sciences, Skåne University Hospital, Lund University, 205 02, Malmō, Sweden |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Dencker |D Magnus |u Clinical and Molecular Osteoporosis Research Unit, Department of Orthopedics and Clinical Sciences, Skåne University Hospital, Lund University, 205 02, Malmō, Sweden |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Nilsson |D Jan-Åke |u Clinical and Molecular Osteoporosis Research Unit, Department of Orthopedics and Clinical Sciences, Skåne University Hospital, Lund University, 205 02, Malmō, Sweden |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Karlsson |D Magnus |u Clinical and Molecular Osteoporosis Research Unit, Department of Orthopedics and Clinical Sciences, Skåne University Hospital, Lund University, 205 02, Malmō, Sweden |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Calcified Tissue International |d Springer US; http://www.springer-ny.com |g 96/5(2015-05-01), 379-388 |x 0171-967X |q 96:5<379 |1 2015 |2 96 |o 223 | ||
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