caa a22 4500 605521441 CHVBK 20210128105158.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00223-015-9965-9 doi (NATIONALLICENCE)springer-10.1007/s00223-015-9965-9 A Pediatric Bone Mass Scan has Poor Ability to Predict Peak Bone Mass: An 11-Year Prospective Study in 121 Children [Elektronische Daten] [Christian Buttazzoni, Bjorn Rosengren, Caroline Karlsson, Magnus Dencker, Jan-Åke Nilsson, Magnus Karlsson] This 11-year prospective longitudinal study examined how a pre-pubertal pediatric bone mass scan predicts peak bone mass. We measured bone mineral content (BMC; g), bone mineral density (BMD; g/cm2), and bone area (cm2) in femoral neck, total body and lumbar spine by dual-energy X-ray absorptiometry in a population-based cohort including 65 boys and 56 girls. At baseline all participants were pre-pubertal with a mean age of 8years (range 6-9), they were re-measured at a mean 11years (range 10-12) later. The participants were then mean 19years (range 18-19), an age range that corresponds to peak bone mass in femoral neck in our population. We calculated individual BMC, BMD, and bone size Z scores, using all participants at each measurement as reference and evaluated correlations between the two measurements. Individual Z scores were also stratified in quartiles to register movements between quartiles from pre-pubertal age to peak bone mass. The correlation coefficients (r) between pre-pubertal and young adulthood measurements for femoral neck BMC, BMD, and bone area varied between 0.37 and 0.65. The reached BMC value at age 8years explained 42% of the variance in the BMC peak value; the corresponding values for BMD were 31% and bone area 14%. Among the participants with femoral neck BMD in the lowest childhood quartile, 52% had left this quartile at peak bone mass. A pediatric bone scan with a femoral neck BMD value in the lowest quartile had a sensitivity of 47% [95% confidence interval (CI) 28, 66] and a specificity of 82% (95% CI 72, 89) to identify individuals who would remain in the lowest quartile at peak bone mass. The pre-pubertal femoral neck BMD explained only 31% of the variance in femoral neck peak bone mass. A pre-pubertal BMD scan in a population-based sample has poor ability to predict individuals who are at risk of low peak bone mass. Springer Science+Business Media New York, 2015 Adult nationallicence BMD nationallicence BMC nationallicence Bone mass nationallicence Child nationallicence Growth nationallicence Peak bone mass nationallicence Buttazzoni Christian Clinical and Molecular Osteoporosis Research Unit, Department of Orthopedics and Clinical Sciences, Skåne University Hospital, Lund University, 205 02, Malmō, Sweden aut Rosengren Bjorn Clinical and Molecular Osteoporosis Research Unit, Department of Orthopedics and Clinical Sciences, Skåne University Hospital, Lund University, 205 02, Malmō, Sweden aut Karlsson Caroline Clinical and Molecular Osteoporosis Research Unit, Department of Orthopedics and Clinical Sciences, Skåne University Hospital, Lund University, 205 02, Malmō, Sweden aut Dencker Magnus Clinical and Molecular Osteoporosis Research Unit, Department of Orthopedics and Clinical Sciences, Skåne University Hospital, Lund University, 205 02, Malmō, Sweden aut Nilsson Jan-Åke Clinical and Molecular Osteoporosis Research Unit, Department of Orthopedics and Clinical Sciences, Skåne University Hospital, Lund University, 205 02, Malmō, Sweden aut Karlsson Magnus Clinical and Molecular Osteoporosis Research Unit, Department of Orthopedics and Clinical Sciences, Skåne University Hospital, Lund University, 205 02, Malmō, Sweden aut Calcified Tissue International Springer US; http://www.springer-ny.com 96/5(2015-05-01), 379-388 0171-967X 96:5<379 2015 96 223 https://doi.org/10.1007/s00223-015-9965-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00223-015-9965-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Buttazzoni Christian Clinical and Molecular Osteoporosis Research Unit, Department of Orthopedics and Clinical Sciences, Skåne University Hospital, Lund University, 205 02, Malmō, Sweden aut NATIONALLICENCE 700 1- Rosengren Bjorn Clinical and Molecular Osteoporosis Research Unit, Department of Orthopedics and Clinical Sciences, Skåne University Hospital, Lund University, 205 02, Malmō, Sweden aut NATIONALLICENCE 700 1- Karlsson Caroline Clinical and Molecular Osteoporosis Research Unit, Department of Orthopedics and Clinical Sciences, Skåne University Hospital, Lund University, 205 02, Malmō, Sweden aut NATIONALLICENCE 700 1- Dencker Magnus Clinical and Molecular Osteoporosis Research Unit, Department of Orthopedics and Clinical Sciences, Skåne University Hospital, Lund University, 205 02, Malmō, Sweden aut NATIONALLICENCE 700 1- Nilsson Jan-Åke Clinical and Molecular Osteoporosis Research Unit, Department of Orthopedics and Clinical Sciences, Skåne University Hospital, Lund University, 205 02, Malmō, Sweden aut NATIONALLICENCE 700 1- Karlsson Magnus Clinical and Molecular Osteoporosis Research Unit, Department of Orthopedics and Clinical Sciences, Skåne University Hospital, Lund University, 205 02, Malmō, Sweden aut NATIONALLICENCE 773 0- Calcified Tissue International Springer US; http://www.springer-ny.com 96/5(2015-05-01), 379-388 0171-967X 96:5<379 2015 96 223 SWISSBIB 560500335