Parathyroid Hormone, Calcium, and Sodium Bridging Between Osteoporosis and Hypertension in Postmenopausal Korean Women

Verfasser / Beitragende:
[Jee Park, Soo Choi, Yumie Rhee, Jai Chung, Eui-Young Choi, Deok Kim]
Ort, Verlag, Jahr:
2015
Enthalten in:
Calcified Tissue International, 96/5(2015-05-01), 417-429
Format:
Artikel (online)
ID: 605521468
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024 7 0 |a 10.1007/s00223-015-9972-x  |2 doi 
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245 0 0 |a Parathyroid Hormone, Calcium, and Sodium Bridging Between Osteoporosis and Hypertension in Postmenopausal Korean Women  |h [Elektronische Daten]  |c [Jee Park, Soo Choi, Yumie Rhee, Jai Chung, Eui-Young Choi, Deok Kim] 
520 3 |a The coexistence of osteoporosis and hypertension, which are considered distinct diseases, has been widely reported. In addition, daily intake of calcium and sodium, as well as parathyroid hormone levels (PTH), is known to be associated with osteoporosis and hypertension. This study aimed to determine the association of low calcium intake, high sodium intake, and PTH levels with osteoporosis and hypertension in postmenopausal Korean women. Data for postmenopausal Korean women aged 50years or older were obtained from the Korea National Health and Nutrition Examination Survey 2008-2011. Osteoporosis was diagnosed using dual energy X-ray absorptiometry, while hypertension was diagnosed using blood pressure data. The odds ratios for osteoporosis and hypertension were calculated using logistic regression analysis for quartiles of the daily calcium intake, daily sodium intake, and PTH levels. Women with hypertension had a high coexistence of osteoporosis (43.6 vs. 36.5%; P=0.022), and vice versa (21.1 vs. 16.6%; P=0.022). PTH was significantly associated with osteoporosis and hypertension, and a high intake of calcium was strongly correlated with a low incidence of osteoporosis. This is the first study to report the characteristics of postmenopausal Korean women who have high dietary sodium intake and low dietary calcium intake, in association with the incidence of osteoporosis and hypertension. Osteoporosis and hypertension were strongly associated with each other, and PTH appears to be a key mediator of both diseases, suggesting a possible pathogenic link. 
540 |a Springer Science+Business Media New York, 2015 
690 7 |a Osteoporosis  |2 nationallicence 
690 7 |a Hypertension  |2 nationallicence 
690 7 |a General population studies  |2 nationallicence 
690 7 |a Sodium  |2 nationallicence 
690 7 |a Calcium  |2 nationallicence 
700 1 |a Park  |D Jee  |u Department of Medical Engineering, Yonsei University College of Medicine, CPO Box 8044, Seoul, Korea  |4 aut 
700 1 |a Choi  |D Soo  |u Department of Medical Engineering, Yonsei University College of Medicine, CPO Box 8044, Seoul, Korea  |4 aut 
700 1 |a Rhee  |D Yumie  |u Division of Endocrinology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea  |4 aut 
700 1 |a Chung  |D Jai  |u Department of Medical Engineering, Yonsei University College of Medicine, CPO Box 8044, Seoul, Korea  |4 aut 
700 1 |a Choi  |D Eui-Young  |u Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea  |4 aut 
700 1 |a Kim  |D Deok  |u Department of Medical Engineering, Yonsei University College of Medicine, CPO Box 8044, Seoul, Korea  |4 aut 
773 0 |t Calcified Tissue International  |d Springer US; http://www.springer-ny.com  |g 96/5(2015-05-01), 417-429  |x 0171-967X  |q 96:5<417  |1 2015  |2 96  |o 223 
856 4 0 |u https://doi.org/10.1007/s00223-015-9972-x  |q text/html  |z Onlinezugriff via DOI 
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900 7 |a Metadata rights reserved  |b Springer special CC-BY-NC licence  |2 nationallicence 
908 |D 1  |a research-article  |2 jats 
949 |B NATIONALLICENCE  |F NATIONALLICENCE  |b NL-springer 
950 |B NATIONALLICENCE  |P 856  |E 40  |u https://doi.org/10.1007/s00223-015-9972-x  |q text/html  |z Onlinezugriff via DOI 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Park  |D Jee  |u Department of Medical Engineering, Yonsei University College of Medicine, CPO Box 8044, Seoul, Korea  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Choi  |D Soo  |u Department of Medical Engineering, Yonsei University College of Medicine, CPO Box 8044, Seoul, Korea  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Rhee  |D Yumie  |u Division of Endocrinology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Chung  |D Jai  |u Department of Medical Engineering, Yonsei University College of Medicine, CPO Box 8044, Seoul, Korea  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Choi  |D Eui-Young  |u Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Kim  |D Deok  |u Department of Medical Engineering, Yonsei University College of Medicine, CPO Box 8044, Seoul, Korea  |4 aut 
950 |B NATIONALLICENCE  |P 773  |E 0-  |t Calcified Tissue International  |d Springer US; http://www.springer-ny.com  |g 96/5(2015-05-01), 417-429  |x 0171-967X  |q 96:5<417  |1 2015  |2 96  |o 223