caa a22 4500 605521468 CHVBK 20210128100740.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00223-015-9972-x doi (NATIONALLICENCE)springer-10.1007/s00223-015-9972-x Parathyroid Hormone, Calcium, and Sodium Bridging Between Osteoporosis and Hypertension in Postmenopausal Korean Women [Elektronische Daten] [Jee Park, Soo Choi, Yumie Rhee, Jai Chung, Eui-Young Choi, Deok Kim] The coexistence of osteoporosis and hypertension, which are considered distinct diseases, has been widely reported. In addition, daily intake of calcium and sodium, as well as parathyroid hormone levels (PTH), is known to be associated with osteoporosis and hypertension. This study aimed to determine the association of low calcium intake, high sodium intake, and PTH levels with osteoporosis and hypertension in postmenopausal Korean women. Data for postmenopausal Korean women aged 50years or older were obtained from the Korea National Health and Nutrition Examination Survey 2008-2011. Osteoporosis was diagnosed using dual energy X-ray absorptiometry, while hypertension was diagnosed using blood pressure data. The odds ratios for osteoporosis and hypertension were calculated using logistic regression analysis for quartiles of the daily calcium intake, daily sodium intake, and PTH levels. Women with hypertension had a high coexistence of osteoporosis (43.6 vs. 36.5%; P=0.022), and vice versa (21.1 vs. 16.6%; P=0.022). PTH was significantly associated with osteoporosis and hypertension, and a high intake of calcium was strongly correlated with a low incidence of osteoporosis. This is the first study to report the characteristics of postmenopausal Korean women who have high dietary sodium intake and low dietary calcium intake, in association with the incidence of osteoporosis and hypertension. Osteoporosis and hypertension were strongly associated with each other, and PTH appears to be a key mediator of both diseases, suggesting a possible pathogenic link. Springer Science+Business Media New York, 2015 Osteoporosis nationallicence Hypertension nationallicence General population studies nationallicence Sodium nationallicence Calcium nationallicence Park Jee Department of Medical Engineering, Yonsei University College of Medicine, CPO Box 8044, Seoul, Korea aut Choi Soo Department of Medical Engineering, Yonsei University College of Medicine, CPO Box 8044, Seoul, Korea aut Rhee Yumie Division of Endocrinology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea aut Chung Jai Department of Medical Engineering, Yonsei University College of Medicine, CPO Box 8044, Seoul, Korea aut Choi Eui-Young Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea aut Kim Deok Department of Medical Engineering, Yonsei University College of Medicine, CPO Box 8044, Seoul, Korea aut Calcified Tissue International Springer US; http://www.springer-ny.com 96/5(2015-05-01), 417-429 0171-967X 96:5<417 2015 96 223 https://doi.org/10.1007/s00223-015-9972-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00223-015-9972-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Park Jee Department of Medical Engineering, Yonsei University College of Medicine, CPO Box 8044, Seoul, Korea aut NATIONALLICENCE 700 1- Choi Soo Department of Medical Engineering, Yonsei University College of Medicine, CPO Box 8044, Seoul, Korea aut NATIONALLICENCE 700 1- Rhee Yumie Division of Endocrinology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Chung Jai Department of Medical Engineering, Yonsei University College of Medicine, CPO Box 8044, Seoul, Korea aut NATIONALLICENCE 700 1- Choi Eui-Young Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Deok Department of Medical Engineering, Yonsei University College of Medicine, CPO Box 8044, Seoul, Korea aut NATIONALLICENCE 773 0- Calcified Tissue International Springer US; http://www.springer-ny.com 96/5(2015-05-01), 417-429 0171-967X 96:5<417 2015 96 223