Development of a Cyclosporin-A-Induced Immune Tolerant Rat Model to Test Marrow Allograft Cell Type Effects on Bone Repair
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| 024 | 7 | 0 | |a 10.1007/s00223-015-9970-z |2 doi |
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| 245 | 0 | 0 | |a Development of a Cyclosporin-A-Induced Immune Tolerant Rat Model to Test Marrow Allograft Cell Type Effects on Bone Repair |h [Elektronische Daten] |c [Florent Espitalier, Nicolas Durand, Séverine Rémy, Pierre Corre, Sophie Sourice, Paul Pilet, Pierre Weiss, Jérôme Guicheux, Olivier Malard] |
| 520 | 3 | |a Bone repair is an important concept in tissue engineering, and the ability to repair bone in hypotrophic conditions such as that of irradiated bone, represents a challenge for this field. Previous studies have shown that a combination of bone marrow and (BCP) was effective to repair irradiated bone. However, the origin and role played by each cell type in bone healing still remains unclear. In order to track the grafted cells, the development of an animal model that is immunotolerant to an allograft of bone marrow would be useful. Furthermore, because the immune system interacts with bone turnover, it is of critical importance to demonstrate that immunosuppressive drugs do not interfere with bone repair. After a preliminary study of immunotolerance, cyclosporin-A was chosen to be used in immunosuppressive therapy. Ten rats were included to observe qualitative and quantitative bone repair 8days and 6weeks after the creation of bone defects. The defects were filled with an allograft of bone marrow alone or in association with BCP under immunosuppressive treatment (cyclosporin-A). The results showed that there was no significant interaction of cyclosporin-A with osseous regeneration. The use of this new immunotolerant rat model of bone marrow allograft in future studies will provide insight on how the cells within the bone marrow graft contribute to bone healing, especially in irradiated conditions. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a Bone repair |2 nationallicence | |
| 690 | 7 | |a Bone marrow allograft |2 nationallicence | |
| 690 | 7 | |a Cyclosporin-A |2 nationallicence | |
| 690 | 7 | |a Immunotolerance |2 nationallicence | |
| 690 | 7 | |a Cell tracking |2 nationallicence | |
| 700 | 1 | |a Espitalier |D Florent |u INSERM, UMRS 791, Laboratoire d'ingénierie ostéo-articulaire et dentaire, LIOAD, 1 place Alexis Ricordeau, 44042, Nantes Cedex 1, France |4 aut | |
| 700 | 1 | |a Durand |D Nicolas |u INSERM, UMRS 791, Laboratoire d'ingénierie ostéo-articulaire et dentaire, LIOAD, 1 place Alexis Ricordeau, 44042, Nantes Cedex 1, France |4 aut | |
| 700 | 1 | |a Rémy |D Séverine |u INSERM, U643, 30 Boulevard Jean Monnot, 44093, Nantes Cedex 1, France |4 aut | |
| 700 | 1 | |a Corre |D Pierre |u INSERM, UMRS 791, Laboratoire d'ingénierie ostéo-articulaire et dentaire, LIOAD, 1 place Alexis Ricordeau, 44042, Nantes Cedex 1, France |4 aut | |
| 700 | 1 | |a Sourice |D Sophie |u INSERM, UMRS 791, Laboratoire d'ingénierie ostéo-articulaire et dentaire, LIOAD, 1 place Alexis Ricordeau, 44042, Nantes Cedex 1, France |4 aut | |
| 700 | 1 | |a Pilet |D Paul |u INSERM, UMRS 791, Laboratoire d'ingénierie ostéo-articulaire et dentaire, LIOAD, 1 place Alexis Ricordeau, 44042, Nantes Cedex 1, France |4 aut | |
| 700 | 1 | |a Weiss |D Pierre |u INSERM, UMRS 791, Laboratoire d'ingénierie ostéo-articulaire et dentaire, LIOAD, 1 place Alexis Ricordeau, 44042, Nantes Cedex 1, France |4 aut | |
| 700 | 1 | |a Guicheux |D Jérôme |u INSERM, UMRS 791, Laboratoire d'ingénierie ostéo-articulaire et dentaire, LIOAD, 1 place Alexis Ricordeau, 44042, Nantes Cedex 1, France |4 aut | |
| 700 | 1 | |a Malard |D Olivier |u INSERM, UMRS 791, Laboratoire d'ingénierie ostéo-articulaire et dentaire, LIOAD, 1 place Alexis Ricordeau, 44042, Nantes Cedex 1, France |4 aut | |
| 773 | 0 | |t Calcified Tissue International |d Springer US; http://www.springer-ny.com |g 96/5(2015-05-01), 430-437 |x 0171-967X |q 96:5<430 |1 2015 |2 96 |o 223 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00223-015-9970-z |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00223-015-9970-z |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Espitalier |D Florent |u INSERM, UMRS 791, Laboratoire d'ingénierie ostéo-articulaire et dentaire, LIOAD, 1 place Alexis Ricordeau, 44042, Nantes Cedex 1, France |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Durand |D Nicolas |u INSERM, UMRS 791, Laboratoire d'ingénierie ostéo-articulaire et dentaire, LIOAD, 1 place Alexis Ricordeau, 44042, Nantes Cedex 1, France |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Rémy |D Séverine |u INSERM, U643, 30 Boulevard Jean Monnot, 44093, Nantes Cedex 1, France |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Corre |D Pierre |u INSERM, UMRS 791, Laboratoire d'ingénierie ostéo-articulaire et dentaire, LIOAD, 1 place Alexis Ricordeau, 44042, Nantes Cedex 1, France |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sourice |D Sophie |u INSERM, UMRS 791, Laboratoire d'ingénierie ostéo-articulaire et dentaire, LIOAD, 1 place Alexis Ricordeau, 44042, Nantes Cedex 1, France |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Pilet |D Paul |u INSERM, UMRS 791, Laboratoire d'ingénierie ostéo-articulaire et dentaire, LIOAD, 1 place Alexis Ricordeau, 44042, Nantes Cedex 1, France |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Weiss |D Pierre |u INSERM, UMRS 791, Laboratoire d'ingénierie ostéo-articulaire et dentaire, LIOAD, 1 place Alexis Ricordeau, 44042, Nantes Cedex 1, France |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Guicheux |D Jérôme |u INSERM, UMRS 791, Laboratoire d'ingénierie ostéo-articulaire et dentaire, LIOAD, 1 place Alexis Ricordeau, 44042, Nantes Cedex 1, France |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Malard |D Olivier |u INSERM, UMRS 791, Laboratoire d'ingénierie ostéo-articulaire et dentaire, LIOAD, 1 place Alexis Ricordeau, 44042, Nantes Cedex 1, France |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Calcified Tissue International |d Springer US; http://www.springer-ny.com |g 96/5(2015-05-01), 430-437 |x 0171-967X |q 96:5<430 |1 2015 |2 96 |o 223 | ||