The Generation of C-3α Epimer of 25-Hydroxyvitamin D and Its Biological Effects on Bone Mineral Density in Adult Rodents
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| 024 | 7 | 0 | |a 10.1007/s00223-015-9973-9 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00223-015-9973-9 | ||
| 245 | 0 | 4 | |a The Generation of C-3α Epimer of 25-Hydroxyvitamin D and Its Biological Effects on Bone Mineral Density in Adult Rodents |h [Elektronische Daten] |c [Christina Bianchini, Paula Lavery, Sherry Agellon, Hope Weiler] |
| 520 | 3 | |a The source and function of C-3α epimer of 25(OH)D (C-3 epimer) is unknown. The objectives were to (1) establish if increasing doses of vitamin D (VD) results in a proportionate dose-response in C-3 epimer; and (2) determine the biological response of bone to C-3 epimer treatment. Sprague Dawley rats (12weeks, n=36 female, n=36 male) were randomized to control AIN93-M diet (1IU VD3/g diet) or an experimental diet for 8weeks containing VD3 at 2 or 4IU/g diet, C-3 epimer at 0.5 or 1IU/g diet or 25(OH)D (0.5IU/g diet). BW and food consumption were measured weekly. Blood was sampled at week 0, 4, and 8 for assessment of VD metabolites and bone metabolism biomarkers. DXA (week 0, 4, and 8) and in vivo micro CT (μCT) (week 0 and 8) were performed in vivo plus ex vivo μCT imaging and bone biomechanics. Dietary intake and anthropometry did not differ among diet groups. The dose-response of VD generated significantly elevated C-3 epimer only in females with concentrations of 4IU VD diet group [mean 84.6 (62.5)nmol/L] exceeding control [mean 21.4 (18.5)nmol/L, p=0.005]. Both sexes in the 25(OH)D group did not show significant increases in C-3 epimer, whereas 0.5 and 1IU epimer groups exceeded 100nmol/L of C-3 epimer by 8weeks. These data suggest C-3 epimer is endogenously generated with higher intakes of VD. Endogenous and exogenous C-3 epimer accumulates in serum without impact upon bone health outcomes in a healthy young adult model over 8weeks. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a Vitamin D |2 nationallicence | |
| 690 | 7 | |a 3-epi-25(OH)D |2 nationallicence | |
| 690 | 7 | |a Cholecalciferol |2 nationallicence | |
| 690 | 7 | |a Bone |2 nationallicence | |
| 690 | 7 | |a Rodents |2 nationallicence | |
| 700 | 1 | |a Bianchini |D Christina |u Dietetics and Human Nutrition, McGill University, Macdonald-Stewart Building, Macdonald Campus, 21111 Lakeshore Road, Ste-Anne-de-Bellevue, H9X 3V9, Montréal, QC, Canada |4 aut | |
| 700 | 1 | |a Lavery |D Paula |u Dietetics and Human Nutrition, McGill University, Macdonald-Stewart Building, Macdonald Campus, 21111 Lakeshore Road, Ste-Anne-de-Bellevue, H9X 3V9, Montréal, QC, Canada |4 aut | |
| 700 | 1 | |a Agellon |D Sherry |u Dietetics and Human Nutrition, McGill University, Macdonald-Stewart Building, Macdonald Campus, 21111 Lakeshore Road, Ste-Anne-de-Bellevue, H9X 3V9, Montréal, QC, Canada |4 aut | |
| 700 | 1 | |a Weiler |D Hope |u Dietetics and Human Nutrition, McGill University, Macdonald-Stewart Building, Macdonald Campus, 21111 Lakeshore Road, Ste-Anne-de-Bellevue, H9X 3V9, Montréal, QC, Canada |4 aut | |
| 773 | 0 | |t Calcified Tissue International |d Springer US; http://www.springer-ny.com |g 96/5(2015-05-01), 453-464 |x 0171-967X |q 96:5<453 |1 2015 |2 96 |o 223 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00223-015-9973-9 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00223-015-9973-9 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Bianchini |D Christina |u Dietetics and Human Nutrition, McGill University, Macdonald-Stewart Building, Macdonald Campus, 21111 Lakeshore Road, Ste-Anne-de-Bellevue, H9X 3V9, Montréal, QC, Canada |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Lavery |D Paula |u Dietetics and Human Nutrition, McGill University, Macdonald-Stewart Building, Macdonald Campus, 21111 Lakeshore Road, Ste-Anne-de-Bellevue, H9X 3V9, Montréal, QC, Canada |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Agellon |D Sherry |u Dietetics and Human Nutrition, McGill University, Macdonald-Stewart Building, Macdonald Campus, 21111 Lakeshore Road, Ste-Anne-de-Bellevue, H9X 3V9, Montréal, QC, Canada |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Weiler |D Hope |u Dietetics and Human Nutrition, McGill University, Macdonald-Stewart Building, Macdonald Campus, 21111 Lakeshore Road, Ste-Anne-de-Bellevue, H9X 3V9, Montréal, QC, Canada |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Calcified Tissue International |d Springer US; http://www.springer-ny.com |g 96/5(2015-05-01), 453-464 |x 0171-967X |q 96:5<453 |1 2015 |2 96 |o 223 | ||