Effect of Vitamin B12 and Folic Acid Supplementation on Bone Mineral Density and Quantitative Ultrasound Parameters in Older People with an Elevated Plasma Homocysteine Level: B-PROOF, a Randomized Controlled Trial
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| 024 | 7 | 0 | |a 10.1007/s00223-015-9968-6 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00223-015-9968-6 | ||
| 245 | 0 | 0 | |a Effect of Vitamin B12 and Folic Acid Supplementation on Bone Mineral Density and Quantitative Ultrasound Parameters in Older People with an Elevated Plasma Homocysteine Level: B-PROOF, a Randomized Controlled Trial |h [Elektronische Daten] |c [Anke Enneman, Karin Swart, Janneke van Wijngaarden, Suzanne van Dijk, Annelies Ham, Elske Brouwer-Brolsma, Nikita van der Zwaluw, Rosalie Dhonukshe-Rutten, Tischa van der Cammen, Lisette de Groot, Joyce van Meurs, Paul Lips, André Uitterlinden, M. Zillikens, Natasja van Schoor, Nathalie van der Velde] |
| 520 | 3 | |a High plasma homocysteine (Hcy) levels are associated with increased osteoporotic fracture incidence. However, the mechanism remains unclear. We investigated the effect of Hcy-lowering vitamin B12 and folic acid treatment on bone mineral density (BMD) and calcaneal quantitative ultrasound (QUS) parameters. This randomized, double-blind, placebo-controlled trial included participants aged ≥65years with plasma Hcy levels between 12 and 50µmol/L. The intervention comprised 2-year supplementation with either a combination of 500µg B12, 400µg folic acid, and 600IU vitamin D or placebo with 600IU vitamin D only. In total, 1111 participants underwent repeated dual-energy X-ray assessment and 1165 participants underwentQUS. Femoral neck (FN) BMD, lumbar spine (LS) BMD, calcaneal broadband ultrasound attenuation (BUA), and calcaneal speed of sound (SOS) were assessed. After 2years, FN-BMD and BUA had significantly decreased, while LS-BMD significantly increased (all p<0.01) and SOS did not change in either treatment arm. No statistically significant differences between the intervention and placebo group were present for FN-BMD (p=0.24), LS-BMD (p=0.16), SOS (p=0.67), and BUA (p=0.96). However, exploratory subgroup analyses revealed a small positive effect of the intervention on BUA at follow-up among compliant persons >80years (estimated marginal mean 64.4dB/MHz for the intervention group and 61.0dB/MHz for the placebo group, p=0.04 for difference). In conclusion, this study showed no overall effect of treatment with vitamin B12 andfolic acid on BMD or QUS parameters in elderly, mildly hyperhomocysteinemic persons, but suggests a small beneficial effect on BUA in persons >80years who were compliant in taking the supplement. | |
| 540 | |a The Author(s), 2015 | ||
| 690 | 7 | |a DXA |2 nationallicence | |
| 690 | 7 | |a QUS |2 nationallicence | |
| 690 | 7 | |a Vitamin B12 |2 nationallicence | |
| 690 | 7 | |a Folic acid |2 nationallicence | |
| 690 | 7 | |a Homocysteine |2 nationallicence | |
| 700 | 1 | |a Enneman |D Anke |u Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands |4 aut | |
| 700 | 1 | |a Swart |D Karin |u Department of Epidemiology and Biostatistics and the EMGO Institute for Health and Care Research, VU University Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands |4 aut | |
| 700 | 1 | |a van Wijngaarden |D Janneke |u Division of Human Nutrition, Wageningen University, P.O. Box 8129, 6700 EV, Wageningen, The Netherlands |4 aut | |
| 700 | 1 | |a van Dijk |D Suzanne |u Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands |4 aut | |
| 700 | 1 | |a Ham |D Annelies |u Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands |4 aut | |
| 700 | 1 | |a Brouwer-Brolsma |D Elske |u Division of Human Nutrition, Wageningen University, P.O. Box 8129, 6700 EV, Wageningen, The Netherlands |4 aut | |
| 700 | 1 | |a van der Zwaluw |D Nikita |u Division of Human Nutrition, Wageningen University, P.O. Box 8129, 6700 EV, Wageningen, The Netherlands |4 aut | |
| 700 | 1 | |a Dhonukshe-Rutten |D Rosalie |u Division of Human Nutrition, Wageningen University, P.O. Box 8129, 6700 EV, Wageningen, The Netherlands |4 aut | |
| 700 | 1 | |a van der Cammen |D Tischa |u Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands |4 aut | |
| 700 | 1 | |a de Groot |D Lisette |u Division of Human Nutrition, Wageningen University, P.O. Box 8129, 6700 EV, Wageningen, The Netherlands |4 aut | |
| 700 | 1 | |a van Meurs |D Joyce |u Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands |4 aut | |
| 700 | 1 | |a Lips |D Paul |u Department of Epidemiology and Biostatistics and the EMGO Institute for Health and Care Research, VU University Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands |4 aut | |
| 700 | 1 | |a Uitterlinden |D André |u Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands |4 aut | |
| 700 | 1 | |a Zillikens |D M. |u Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands |4 aut | |
| 700 | 1 | |a van Schoor |D Natasja |u Department of Epidemiology and Biostatistics and the EMGO Institute for Health and Care Research, VU University Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands |4 aut | |
| 700 | 1 | |a van der Velde |D Nathalie |u Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands |4 aut | |
| 773 | 0 | |t Calcified Tissue International |d Springer US; http://www.springer-ny.com |g 96/5(2015-05-01), 401-409 |x 0171-967X |q 96:5<401 |1 2015 |2 96 |o 223 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00223-015-9968-6 |q text/html |z Onlinezugriff via DOI |
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| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00223-015-9968-6 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Enneman |D Anke |u Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Swart |D Karin |u Department of Epidemiology and Biostatistics and the EMGO Institute for Health and Care Research, VU University Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a van Wijngaarden |D Janneke |u Division of Human Nutrition, Wageningen University, P.O. Box 8129, 6700 EV, Wageningen, The Netherlands |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a van Dijk |D Suzanne |u Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ham |D Annelies |u Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Brouwer-Brolsma |D Elske |u Division of Human Nutrition, Wageningen University, P.O. Box 8129, 6700 EV, Wageningen, The Netherlands |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a van der Zwaluw |D Nikita |u Division of Human Nutrition, Wageningen University, P.O. Box 8129, 6700 EV, Wageningen, The Netherlands |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Dhonukshe-Rutten |D Rosalie |u Division of Human Nutrition, Wageningen University, P.O. Box 8129, 6700 EV, Wageningen, The Netherlands |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a van der Cammen |D Tischa |u Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a de Groot |D Lisette |u Division of Human Nutrition, Wageningen University, P.O. Box 8129, 6700 EV, Wageningen, The Netherlands |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a van Meurs |D Joyce |u Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Lips |D Paul |u Department of Epidemiology and Biostatistics and the EMGO Institute for Health and Care Research, VU University Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Uitterlinden |D André |u Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zillikens |D M. |u Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a van Schoor |D Natasja |u Department of Epidemiology and Biostatistics and the EMGO Institute for Health and Care Research, VU University Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a van der Velde |D Nathalie |u Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Calcified Tissue International |d Springer US; http://www.springer-ny.com |g 96/5(2015-05-01), 401-409 |x 0171-967X |q 96:5<401 |1 2015 |2 96 |o 223 | ||