The Association Between Vitamin D Status and Parameters for Bone Density and Quality is Modified by Body Mass Index
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| 024 | 7 | 0 | |a 10.1007/s00223-014-9943-7 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00223-014-9943-7 | ||
| 245 | 0 | 4 | |a The Association Between Vitamin D Status and Parameters for Bone Density and Quality is Modified by Body Mass Index |h [Elektronische Daten] |c [E. Sohl, R. de Jongh, K. Swart, A. Enneman, J. van Wijngaarden, S. van Dijk, A. Ham, N. van der Zwaluw, E. Brouwer-Brolsma, N. van der Velde, C. de Groot, S. te Velde, P. Lips, N. van Schoor] |
| 520 | 3 | |a The association of vitamin D status with bone mineral density (BMD) and Quantitative Ultrasound measurements (QUS) has been inconsistent in previous studies, probably caused by moderating effects. This study explored (1) the association of vitamin D status with QUS and BMD, and (2) whether these associations were modified by body mass index (BMI), age, gender, or physical activity. Two-independent cohorts of the Longitudinal Aging Study Amsterdam (LASA-I, 1995/1996, aged ≥65; LASA-II, 2008/2009, aged 61-71) and baseline measurement of the B-vitamins for the prevention of osteoporotic fractures (B-PROOF) study (2008-2011, aged 65+) were used. QUS measurements [broadband ultrasound attenuation (BUA) and speed of sound (SOS)] were performed at the calcaneus in all three cohorts (N=1,235, N=365, N=1319); BMD was measured by Dual X-ray absorptiometry (DXA) in B-PROOF (N=1,162 and 1,192 for specific sites) and LASA-I (N=492 and 503). The associations of vitamin D status with BUA and BMD were modified by BMI. Only in persons with low-to-normal BMI (<25kg/m2) and serum 25(OH)D <25nmol/L was associated with lower BUA as compared to the reference group (≥50nmol/L) in LASA-I and B-PROOF. Furthermore, in LASA-I, these individuals had lower BMD at the hip and lumbar spine. In LASA-II, no associations with BUA were observed. Vitamin D status was not associated with SOS, and these associations were not modified by the effect modifiers tested. The association between vitamin D status and BUA and BMD was modified by BMI in the older-aged cohorts: there was only an association in individuals with BMI <25kg/m2. | |
| 540 | |a Springer Science+Business Media New York, 2014 | ||
| 690 | 7 | |a Bone mineral density |2 nationallicence | |
| 690 | 7 | |a Quantitative ultrasound |2 nationallicence | |
| 690 | 7 | |a Vitamin D |2 nationallicence | |
| 690 | 7 | |a Older individuals |2 nationallicence | |
| 690 | 7 | |a Body mass index |2 nationallicence | |
| 700 | 1 | |a Sohl |D E. |u Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, Van der Boechorststraat 7, Room A517, 1081 BT, Amsterdam, The Netherlands |4 aut | |
| 700 | 1 | |a de Jongh |D R. |u Department of Internal Medicine and Endocrinology, VU University Medical Center, Amsterdam, The Netherlands |4 aut | |
| 700 | 1 | |a Swart |D K. |u Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, Van der Boechorststraat 7, Room A517, 1081 BT, Amsterdam, The Netherlands |4 aut | |
| 700 | 1 | |a Enneman |D A. |u Department of Internal Medicine, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands |4 aut | |
| 700 | 1 | |a van Wijngaarden |D J. |u Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands |4 aut | |
| 700 | 1 | |a van Dijk |D S. |u Department of Internal Medicine, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands |4 aut | |
| 700 | 1 | |a Ham |D A. |u Department of Internal Medicine, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands |4 aut | |
| 700 | 1 | |a van der Zwaluw |D N. |u Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands |4 aut | |
| 700 | 1 | |a Brouwer-Brolsma |D E. |u Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands |4 aut | |
| 700 | 1 | |a van der Velde |D N. |u Department of Internal Medicine, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands |4 aut | |
| 700 | 1 | |a de Groot |D C. |u Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands |4 aut | |
| 700 | 1 | |a te Velde |D S. |u Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, Van der Boechorststraat 7, Room A517, 1081 BT, Amsterdam, The Netherlands |4 aut | |
| 700 | 1 | |a Lips |D P. |u Department of Internal Medicine and Endocrinology, VU University Medical Center, Amsterdam, The Netherlands |4 aut | |
| 700 | 1 | |a van Schoor |D N. |u Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, Van der Boechorststraat 7, Room A517, 1081 BT, Amsterdam, The Netherlands |4 aut | |
| 773 | 0 | |t Calcified Tissue International |d Springer US; http://www.springer-ny.com |g 96/2(2015-02-01), 113-122 |x 0171-967X |q 96:2<113 |1 2015 |2 96 |o 223 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00223-014-9943-7 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00223-014-9943-7 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sohl |D E. |u Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, Van der Boechorststraat 7, Room A517, 1081 BT, Amsterdam, The Netherlands |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a de Jongh |D R. |u Department of Internal Medicine and Endocrinology, VU University Medical Center, Amsterdam, The Netherlands |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Swart |D K. |u Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, Van der Boechorststraat 7, Room A517, 1081 BT, Amsterdam, The Netherlands |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Enneman |D A. |u Department of Internal Medicine, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a van Wijngaarden |D J. |u Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a van Dijk |D S. |u Department of Internal Medicine, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ham |D A. |u Department of Internal Medicine, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a van der Zwaluw |D N. |u Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Brouwer-Brolsma |D E. |u Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a van der Velde |D N. |u Department of Internal Medicine, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a de Groot |D C. |u Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a te Velde |D S. |u Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, Van der Boechorststraat 7, Room A517, 1081 BT, Amsterdam, The Netherlands |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Lips |D P. |u Department of Internal Medicine and Endocrinology, VU University Medical Center, Amsterdam, The Netherlands |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a van Schoor |D N. |u Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, Van der Boechorststraat 7, Room A517, 1081 BT, Amsterdam, The Netherlands |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Calcified Tissue International |d Springer US; http://www.springer-ny.com |g 96/2(2015-02-01), 113-122 |x 0171-967X |q 96:2<113 |1 2015 |2 96 |o 223 | ||