caa a22 4500 605521549 CHVBK 20210128100741.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s00223-014-9943-7 doi (NATIONALLICENCE)springer-10.1007/s00223-014-9943-7 The Association Between Vitamin D Status and Parameters for Bone Density and Quality is Modified by Body Mass Index [Elektronische Daten] [E. Sohl, R. de Jongh, K. Swart, A. Enneman, J. van Wijngaarden, S. van Dijk, A. Ham, N. van der Zwaluw, E. Brouwer-Brolsma, N. van der Velde, C. de Groot, S. te Velde, P. Lips, N. van Schoor] The association of vitamin D status with bone mineral density (BMD) and Quantitative Ultrasound measurements (QUS) has been inconsistent in previous studies, probably caused by moderating effects. This study explored (1) the association of vitamin D status with QUS and BMD, and (2) whether these associations were modified by body mass index (BMI), age, gender, or physical activity. Two-independent cohorts of the Longitudinal Aging Study Amsterdam (LASA-I, 1995/1996, aged ≥65; LASA-II, 2008/2009, aged 61-71) and baseline measurement of the B-vitamins for the prevention of osteoporotic fractures (B-PROOF) study (2008-2011, aged 65+) were used. QUS measurements [broadband ultrasound attenuation (BUA) and speed of sound (SOS)] were performed at the calcaneus in all three cohorts (N=1,235, N=365, N=1319); BMD was measured by Dual X-ray absorptiometry (DXA) in B-PROOF (N=1,162 and 1,192 for specific sites) and LASA-I (N=492 and 503). The associations of vitamin D status with BUA and BMD were modified by BMI. Only in persons with low-to-normal BMI (<25kg/m2) and serum 25(OH)D <25nmol/L was associated with lower BUA as compared to the reference group (≥50nmol/L) in LASA-I and B-PROOF. Furthermore, in LASA-I, these individuals had lower BMD at the hip and lumbar spine. In LASA-II, no associations with BUA were observed. Vitamin D status was not associated with SOS, and these associations were not modified by the effect modifiers tested. The association between vitamin D status and BUA and BMD was modified by BMI in the older-aged cohorts: there was only an association in individuals with BMI <25kg/m2. Springer Science+Business Media New York, 2014 Bone mineral density nationallicence Quantitative ultrasound nationallicence Vitamin D nationallicence Older individuals nationallicence Body mass index nationallicence Sohl E. Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, Van der Boechorststraat 7, Room A517, 1081 BT, Amsterdam, The Netherlands aut de Jongh R. Department of Internal Medicine and Endocrinology, VU University Medical Center, Amsterdam, The Netherlands aut Swart K. Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, Van der Boechorststraat 7, Room A517, 1081 BT, Amsterdam, The Netherlands aut Enneman A. Department of Internal Medicine, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands aut van Wijngaarden J. Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands aut van Dijk S. Department of Internal Medicine, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands aut Ham A. Department of Internal Medicine, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands aut van der Zwaluw N. Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands aut Brouwer-Brolsma E. Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands aut van der Velde N. Department of Internal Medicine, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands aut de Groot C. Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands aut te Velde S. Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, Van der Boechorststraat 7, Room A517, 1081 BT, Amsterdam, The Netherlands aut Lips P. Department of Internal Medicine and Endocrinology, VU University Medical Center, Amsterdam, The Netherlands aut van Schoor N. Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, Van der Boechorststraat 7, Room A517, 1081 BT, Amsterdam, The Netherlands aut Calcified Tissue International Springer US; http://www.springer-ny.com 96/2(2015-02-01), 113-122 0171-967X 96:2<113 2015 96 223 https://doi.org/10.1007/s00223-014-9943-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00223-014-9943-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sohl E. Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, Van der Boechorststraat 7, Room A517, 1081 BT, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- de Jongh R. Department of Internal Medicine and Endocrinology, VU University Medical Center, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Swart K. Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, Van der Boechorststraat 7, Room A517, 1081 BT, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Enneman A. Department of Internal Medicine, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- van Wijngaarden J. Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands aut NATIONALLICENCE 700 1- van Dijk S. Department of Internal Medicine, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- Ham A. Department of Internal Medicine, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- van der Zwaluw N. Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands aut NATIONALLICENCE 700 1- Brouwer-Brolsma E. Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands aut NATIONALLICENCE 700 1- van der Velde N. Department of Internal Medicine, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- de Groot C. Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands aut NATIONALLICENCE 700 1- te Velde S. Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, Van der Boechorststraat 7, Room A517, 1081 BT, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Lips P. Department of Internal Medicine and Endocrinology, VU University Medical Center, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- van Schoor N. Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, Van der Boechorststraat 7, Room A517, 1081 BT, Amsterdam, The Netherlands aut NATIONALLICENCE 773 0- Calcified Tissue International Springer US; http://www.springer-ny.com 96/2(2015-02-01), 113-122 0171-967X 96:2<113 2015 96 223