caa a22 4500 605521557 CHVBK 20210128100741.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s00223-014-9946-4 doi (NATIONALLICENCE)springer-10.1007/s00223-014-9946-4 Is There an Interaction Between Socioeconomic Status and FRAX 10-Year Fracture Probability Determined With and Without Bone Density Measures? Data from the Geelong Osteoporosis Study of Female Cohort [Elektronische Daten] [S. Brennan, S. Quirk, S. Hosking, M. Kotowicz, K. Holloway, D. Moloney, A. Dobbins, J. Pasco] FRAX© evaluates 10-year fracture probabilities and can be calculated with and without bone mineral density (BMD). Low socioeconomic status (SES) may affect BMD, and is associated with increased fracture risk. Clinical risk factors differ by SES; however, it is unknown whether aninteraction exists between SES and FRAX determined with and without the BMD. From the Geelong Osteoporosis Study, we drew 819 females aged ≥50years. Clinical data were collected during 1993-1997. SES was determined by cross-referencing residential addresses with Australian Bureau of Statistics census data and categorized in quintiles. BMD was measured by dual energy X-ray absorptiometry at the same time as other clinical data were collected. Ten-year fracture probabilities were calculated using FRAX (Australia). Using multivariable regression analyses, we examined whether interactions existed between SES and 10-year probability for hip and any major osteoporotic fracture (MOF) defined by use of FRAX with and without BMD. We observed a trend for a SES*FRAXno-BMD interaction term for 10-year hip fracture probability (p=0.09); however, not for MOF (p=0.42). In women without prior fracture (n=518), we observed a significant SES*FRAXno-BMD interaction term for hip fracture (p=0.03) and MOF (p=0.04). SES does not appear to have an interaction with 10-year fracture probabilities determined by FRAX with and without BMD in women with previous fracture; however, it does appear to exist for those without previous fracture. Springer Science+Business Media New York, 2015 Australia nationallicence Bone mineral density nationallicence FRAX nationallicence Social disadvantage nationallicence Women nationallicence Brennan S. School of Medicine, Deakin University, 3220, Geelong, VIC, Australia aut Quirk S. School of Medicine, Deakin University, 3220, Geelong, VIC, Australia aut Hosking S. School of Medicine, Deakin University, 3220, Geelong, VIC, Australia aut Kotowicz M. NorthWest Academic Centre, The University of Melbourne, 3021, St Albans, VIC, Australia aut Holloway K. School of Medicine, Deakin University, 3220, Geelong, VIC, Australia aut Moloney D. School of Medicine, Deakin University, 3220, Geelong, VIC, Australia aut Dobbins A. School of Medicine, Deakin University, 3220, Geelong, VIC, Australia aut Pasco J. School of Medicine, Deakin University, 3220, Geelong, VIC, Australia aut Calcified Tissue International Springer US; http://www.springer-ny.com 96/2(2015-02-01), 138-144 0171-967X 96:2<138 2015 96 223 https://doi.org/10.1007/s00223-014-9946-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00223-014-9946-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Brennan S. School of Medicine, Deakin University, 3220, Geelong, VIC, Australia aut NATIONALLICENCE 700 1- Quirk S. School of Medicine, Deakin University, 3220, Geelong, VIC, Australia aut NATIONALLICENCE 700 1- Hosking S. School of Medicine, Deakin University, 3220, Geelong, VIC, Australia aut NATIONALLICENCE 700 1- Kotowicz M. NorthWest Academic Centre, The University of Melbourne, 3021, St Albans, VIC, Australia aut NATIONALLICENCE 700 1- Holloway K. School of Medicine, Deakin University, 3220, Geelong, VIC, Australia aut NATIONALLICENCE 700 1- Moloney D. School of Medicine, Deakin University, 3220, Geelong, VIC, Australia aut NATIONALLICENCE 700 1- Dobbins A. School of Medicine, Deakin University, 3220, Geelong, VIC, Australia aut NATIONALLICENCE 700 1- Pasco J. School of Medicine, Deakin University, 3220, Geelong, VIC, Australia aut NATIONALLICENCE 773 0- Calcified Tissue International Springer US; http://www.springer-ny.com 96/2(2015-02-01), 138-144 0171-967X 96:2<138 2015 96 223