Differences in Bone Mineral Density, Markers of Bone Turnover and Extracellular Matrix and Daily Life Muscular Activity Among Patients with Recent Motor-Incomplete Versus Motor-Complete Spinal Cord Injury
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| 024 | 7 | 0 | |a 10.1007/s00223-014-9947-3 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00223-014-9947-3 | ||
| 245 | 0 | 0 | |a Differences in Bone Mineral Density, Markers of Bone Turnover and Extracellular Matrix and Daily Life Muscular Activity Among Patients with Recent Motor-Incomplete Versus Motor-Complete Spinal Cord Injury |h [Elektronische Daten] |c [E. Kostovski, N. Hjeltnes, E. Eriksen, S. Kolset, P. Iversen] |
| 520 | 3 | |a Spinal cord injury (SCI) leads to severe bone loss, but the associated mechanisms are poorly described in incomplete SCI individuals. The purpose of the study is to compare alterations in bone mineral density (BMD) and serum biomarkers of bone turnover in recent motor-incomplete to -complete SCI men, as well as to describe their physical activity and spasticity. We studied 31 men with acute SCI. Whole-body DXA scans, serum biomarkers and self-reported activity and spasticity were examined 1 and/or 3 and 12months after the injury. We observed a decrease in proximal femur BMD (p<0.02) in both the groups. Serum phosphate and carboxy-terminal-collagen crosslinks were significantly lower in motor-incomplete versus complete SCI men, whereas albumin-corrected Ca2+ (p=0.02) were lower only 3months after injury. When data from all 31 SCI participants were pooled, we observed increased serum matrix metalloproteinase-2 (MMP-2) and tissue inhibitors of MMP-2 (TIMP-2) (p<0.02) whereas TIMP-1 decreased (p=0.03). BMD correlated positively with self-reported activity (r=0.59, p=0.04) and negatively with spasticity (r=0.74, p=0.02) 12months after injury. As a summary, men with motor-incomplete SCI developed significant proximal femur bone loss 12months after injury and exhibited increased bone resorption throughout the first year after the injury. Compared with complete SCI men, incomplete SCI men show attenuated bone resorption. Our pooled data show increased turnover of extracellular matrix after injury and that increased exercise before and after injury correlated with reduced bone loss. | |
| 540 | |a Springer Science+Business Media New York, 2014 | ||
| 690 | 7 | |a Bone metabolism |2 nationallicence | |
| 690 | 7 | |a Extracellular matrix |2 nationallicence | |
| 690 | 7 | |a Physical activity |2 nationallicence | |
| 690 | 7 | |a Spasticity and spinal cord injury |2 nationallicence | |
| 700 | 1 | |a Kostovski |D E. |u Department of Science, Sunnaas Rehabilitation Hospital, Nesoddtangen, Norway |4 aut | |
| 700 | 1 | |a Hjeltnes |D N. |u Sunnaas Rehabilitation Hospital, Nesoddtangen, Norway |4 aut | |
| 700 | 1 | |a Eriksen |D E. |u Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway |4 aut | |
| 700 | 1 | |a Kolset |D S. |u Department of Nutrition, University of Oslo, Oslo, Norway |4 aut | |
| 700 | 1 | |a Iversen |D P. |u Department of Nutrition, University of Oslo, Oslo, Norway |4 aut | |
| 773 | 0 | |t Calcified Tissue International |d Springer US; http://www.springer-ny.com |g 96/2(2015-02-01), 145-154 |x 0171-967X |q 96:2<145 |1 2015 |2 96 |o 223 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00223-014-9947-3 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00223-014-9947-3 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kostovski |D E. |u Department of Science, Sunnaas Rehabilitation Hospital, Nesoddtangen, Norway |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Hjeltnes |D N. |u Sunnaas Rehabilitation Hospital, Nesoddtangen, Norway |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Eriksen |D E. |u Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kolset |D S. |u Department of Nutrition, University of Oslo, Oslo, Norway |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Iversen |D P. |u Department of Nutrition, University of Oslo, Oslo, Norway |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Calcified Tissue International |d Springer US; http://www.springer-ny.com |g 96/2(2015-02-01), 145-154 |x 0171-967X |q 96:2<145 |1 2015 |2 96 |o 223 | ||