caa a22 4500 605521603 CHVBK 20210128100741.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s00223-014-9947-3 doi (NATIONALLICENCE)springer-10.1007/s00223-014-9947-3 Differences in Bone Mineral Density, Markers of Bone Turnover and Extracellular Matrix and Daily Life Muscular Activity Among Patients with Recent Motor-Incomplete Versus Motor-Complete Spinal Cord Injury [Elektronische Daten] [E. Kostovski, N. Hjeltnes, E. Eriksen, S. Kolset, P. Iversen] Spinal cord injury (SCI) leads to severe bone loss, but the associated mechanisms are poorly described in incomplete SCI individuals. The purpose of the study is to compare alterations in bone mineral density (BMD) and serum biomarkers of bone turnover in recent motor-incomplete to -complete SCI men, as well as to describe their physical activity and spasticity. We studied 31 men with acute SCI. Whole-body DXA scans, serum biomarkers and self-reported activity and spasticity were examined 1 and/or 3 and 12months after the injury. We observed a decrease in proximal femur BMD (p<0.02) in both the groups. Serum phosphate and carboxy-terminal-collagen crosslinks were significantly lower in motor-incomplete versus complete SCI men, whereas albumin-corrected Ca2+ (p=0.02) were lower only 3months after injury. When data from all 31 SCI participants were pooled, we observed increased serum matrix metalloproteinase-2 (MMP-2) and tissue inhibitors of MMP-2 (TIMP-2) (p<0.02) whereas TIMP-1 decreased (p=0.03). BMD correlated positively with self-reported activity (r=0.59, p=0.04) and negatively with spasticity (r=0.74, p=0.02) 12months after injury. As a summary, men with motor-incomplete SCI developed significant proximal femur bone loss 12months after injury and exhibited increased bone resorption throughout the first year after the injury. Compared with complete SCI men, incomplete SCI men show attenuated bone resorption. Our pooled data show increased turnover of extracellular matrix after injury and that increased exercise before and after injury correlated with reduced bone loss. Springer Science+Business Media New York, 2014 Bone metabolism nationallicence Extracellular matrix nationallicence Physical activity nationallicence Spasticity and spinal cord injury nationallicence Kostovski E. Department of Science, Sunnaas Rehabilitation Hospital, Nesoddtangen, Norway aut Hjeltnes N. Sunnaas Rehabilitation Hospital, Nesoddtangen, Norway aut Eriksen E. Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway aut Kolset S. Department of Nutrition, University of Oslo, Oslo, Norway aut Iversen P. Department of Nutrition, University of Oslo, Oslo, Norway aut Calcified Tissue International Springer US; http://www.springer-ny.com 96/2(2015-02-01), 145-154 0171-967X 96:2<145 2015 96 223 https://doi.org/10.1007/s00223-014-9947-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00223-014-9947-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kostovski E. Department of Science, Sunnaas Rehabilitation Hospital, Nesoddtangen, Norway aut NATIONALLICENCE 700 1- Hjeltnes N. Sunnaas Rehabilitation Hospital, Nesoddtangen, Norway aut NATIONALLICENCE 700 1- Eriksen E. Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway aut NATIONALLICENCE 700 1- Kolset S. Department of Nutrition, University of Oslo, Oslo, Norway aut NATIONALLICENCE 700 1- Iversen P. Department of Nutrition, University of Oslo, Oslo, Norway aut NATIONALLICENCE 773 0- Calcified Tissue International Springer US; http://www.springer-ny.com 96/2(2015-02-01), 145-154 0171-967X 96:2<145 2015 96 223