The Risk-Stratified Osteoporosis Strategy Evaluation study (ROSE): A Randomized Prospective Population-Based Study. Design and Baseline Characteristics
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| 024 | 7 | 0 | |a 10.1007/s00223-014-9950-8 |2 doi |
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| 245 | 0 | 4 | |a The Risk-Stratified Osteoporosis Strategy Evaluation study (ROSE): A Randomized Prospective Population-Based Study. Design and Baseline Characteristics |h [Elektronische Daten] |c [Katrine Rubin, Teresa Holmberg, Mette Rothmann, Mikkel Høiberg, Reinhard Barkmann, Jeppe Gram, Anne Hermann, Mickael Bech, Ole Rasmussen, Claus Glüer, Kim Brixen] |
| 520 | 3 | |a The risk-stratified osteoporosis strategy evaluation study (ROSE) is a randomized prospective population-based study investigating the effectiveness of a two-step screening program for osteoporosis in women. This paper reports the study design and baseline characteristics of the study population. 35,000 women aged 65-80years were selected at random from the population in the Region of Southern Denmark and—before inclusion—randomized to either a screening group or a control group. As first step, a self-administered questionnaire regarding risk factors for osteoporosis based on FRAX® was issued to both groups. As second step, subjects in the screening group with a 10-year probability of major osteoporotic fractures ≥15% were offered a DXA scan. Patients diagnosed with osteoporosis from the DXA scan were advised to see their GP and discuss pharmaceutical treatment according to Danish National guidelines. The primary outcome is incident clinical fractures as evaluated through annual follow-up using the Danish National Patient Registry. The secondary outcomes are cost-effectiveness, participation rate, and patient preferences. 20,904 (60%) women participated and included in the baseline analyses (10,411 in screening and 10,949 in control group). The mean age was 71years. As expected by randomization, the screening and control groups had similar baseline characteristics. Screening for osteoporosis is at present not evidence based according to the WHO screening criteria. The ROSE study is expected to provide knowledge of the effectiveness of a screening strategy that may be implemented in health care systems to prevent fractures. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a Risk factors |2 nationallicence | |
| 690 | 7 | |a Fracture prevention |2 nationallicence | |
| 690 | 7 | |a Osteoporosis |2 nationallicence | |
| 690 | 7 | |a Screening |2 nationallicence | |
| 690 | 7 | |a Women |2 nationallicence | |
| 700 | 1 | |a Rubin |D Katrine |u Odense Patient data Explorative Network (OPEN), Institute of Clinical Research, University of Southern Denmark, J. B. Winsløws Vej 9 a, 3th Floor, 5000, Odense C, Denmark |4 aut | |
| 700 | 1 | |a Holmberg |D Teresa |u National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark |4 aut | |
| 700 | 1 | |a Rothmann |D Mette |u Department of Medical Endocrinology, Odense University Hospital, Odense C, Denmark |4 aut | |
| 700 | 1 | |a Høiberg |D Mikkel |u Department of Medical Endocrinology, Oslo University Hospital Aker, Oslo, Norway |4 aut | |
| 700 | 1 | |a Barkmann |D Reinhard |u Section Biomedical Imaging, Department of Radiology and Neuroradiology, University Hospital Schleswig-Holstein, Kiel, Germany |4 aut | |
| 700 | 1 | |a Gram |D Jeppe |u Department of Endocrinology, Hospital of Southwest Denmark, Esbjerg, Denmark |4 aut | |
| 700 | 1 | |a Hermann |D Anne |u Department of Medical Endocrinology, Odense University Hospital, Odense C, Denmark |4 aut | |
| 700 | 1 | |a Bech |D Mickael |u Department of Business and Economics, COHERE, University of Southern Denmark, Odense, Denmark |4 aut | |
| 700 | 1 | |a Rasmussen |D Ole |u Department of Internal Medicine, Sygehus Lillebælt, Kolding, Denmark |4 aut | |
| 700 | 1 | |a Glüer |D Claus |u Section Biomedical Imaging, Department of Radiology and Neuroradiology, University Hospital Schleswig-Holstein, Kiel, Germany |4 aut | |
| 700 | 1 | |a Brixen |D Kim |u Department of Medical Endocrinology, Odense University Hospital, Odense C, Denmark |4 aut | |
| 773 | 0 | |t Calcified Tissue International |d Springer US; http://www.springer-ny.com |g 96/2(2015-02-01), 167-179 |x 0171-967X |q 96:2<167 |1 2015 |2 96 |o 223 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00223-014-9950-8 |q text/html |z Onlinezugriff via DOI |
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| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00223-014-9950-8 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Rubin |D Katrine |u Odense Patient data Explorative Network (OPEN), Institute of Clinical Research, University of Southern Denmark, J. B. Winsløws Vej 9 a, 3th Floor, 5000, Odense C, Denmark |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Holmberg |D Teresa |u National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Rothmann |D Mette |u Department of Medical Endocrinology, Odense University Hospital, Odense C, Denmark |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Høiberg |D Mikkel |u Department of Medical Endocrinology, Oslo University Hospital Aker, Oslo, Norway |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Barkmann |D Reinhard |u Section Biomedical Imaging, Department of Radiology and Neuroradiology, University Hospital Schleswig-Holstein, Kiel, Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Gram |D Jeppe |u Department of Endocrinology, Hospital of Southwest Denmark, Esbjerg, Denmark |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Hermann |D Anne |u Department of Medical Endocrinology, Odense University Hospital, Odense C, Denmark |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Bech |D Mickael |u Department of Business and Economics, COHERE, University of Southern Denmark, Odense, Denmark |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Rasmussen |D Ole |u Department of Internal Medicine, Sygehus Lillebælt, Kolding, Denmark |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Glüer |D Claus |u Section Biomedical Imaging, Department of Radiology and Neuroradiology, University Hospital Schleswig-Holstein, Kiel, Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Brixen |D Kim |u Department of Medical Endocrinology, Odense University Hospital, Odense C, Denmark |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Calcified Tissue International |d Springer US; http://www.springer-ny.com |g 96/2(2015-02-01), 167-179 |x 0171-967X |q 96:2<167 |1 2015 |2 96 |o 223 | ||