caa a22 4500 605521638 CHVBK 20210128100741.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s00223-014-9950-8 doi (NATIONALLICENCE)springer-10.1007/s00223-014-9950-8 The Risk-Stratified Osteoporosis Strategy Evaluation study (ROSE): A Randomized Prospective Population-Based Study. Design and Baseline Characteristics [Elektronische Daten] [Katrine Rubin, Teresa Holmberg, Mette Rothmann, Mikkel Høiberg, Reinhard Barkmann, Jeppe Gram, Anne Hermann, Mickael Bech, Ole Rasmussen, Claus Glüer, Kim Brixen] The risk-stratified osteoporosis strategy evaluation study (ROSE) is a randomized prospective population-based study investigating the effectiveness of a two-step screening program for osteoporosis in women. This paper reports the study design and baseline characteristics of the study population. 35,000 women aged 65-80years were selected at random from the population in the Region of Southern Denmark and—before inclusion—randomized to either a screening group or a control group. As first step, a self-administered questionnaire regarding risk factors for osteoporosis based on FRAX® was issued to both groups. As second step, subjects in the screening group with a 10-year probability of major osteoporotic fractures ≥15% were offered a DXA scan. Patients diagnosed with osteoporosis from the DXA scan were advised to see their GP and discuss pharmaceutical treatment according to Danish National guidelines. The primary outcome is incident clinical fractures as evaluated through annual follow-up using the Danish National Patient Registry. The secondary outcomes are cost-effectiveness, participation rate, and patient preferences. 20,904 (60%) women participated and included in the baseline analyses (10,411 in screening and 10,949 in control group). The mean age was 71years. As expected by randomization, the screening and control groups had similar baseline characteristics. Screening for osteoporosis is at present not evidence based according to the WHO screening criteria. The ROSE study is expected to provide knowledge of the effectiveness of a screening strategy that may be implemented in health care systems to prevent fractures. Springer Science+Business Media New York, 2015 Risk factors nationallicence Fracture prevention nationallicence Osteoporosis nationallicence Screening nationallicence Women nationallicence Rubin Katrine Odense Patient data Explorative Network (OPEN), Institute of Clinical Research, University of Southern Denmark, J. B. Winsløws Vej 9 a, 3th Floor, 5000, Odense C, Denmark aut Holmberg Teresa National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark aut Rothmann Mette Department of Medical Endocrinology, Odense University Hospital, Odense C, Denmark aut Høiberg Mikkel Department of Medical Endocrinology, Oslo University Hospital Aker, Oslo, Norway aut Barkmann Reinhard Section Biomedical Imaging, Department of Radiology and Neuroradiology, University Hospital Schleswig-Holstein, Kiel, Germany aut Gram Jeppe Department of Endocrinology, Hospital of Southwest Denmark, Esbjerg, Denmark aut Hermann Anne Department of Medical Endocrinology, Odense University Hospital, Odense C, Denmark aut Bech Mickael Department of Business and Economics, COHERE, University of Southern Denmark, Odense, Denmark aut Rasmussen Ole Department of Internal Medicine, Sygehus Lillebælt, Kolding, Denmark aut Glüer Claus Section Biomedical Imaging, Department of Radiology and Neuroradiology, University Hospital Schleswig-Holstein, Kiel, Germany aut Brixen Kim Department of Medical Endocrinology, Odense University Hospital, Odense C, Denmark aut Calcified Tissue International Springer US; http://www.springer-ny.com 96/2(2015-02-01), 167-179 0171-967X 96:2<167 2015 96 223 https://doi.org/10.1007/s00223-014-9950-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00223-014-9950-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rubin Katrine Odense Patient data Explorative Network (OPEN), Institute of Clinical Research, University of Southern Denmark, J. B. Winsløws Vej 9 a, 3th Floor, 5000, Odense C, Denmark aut NATIONALLICENCE 700 1- Holmberg Teresa National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark aut NATIONALLICENCE 700 1- Rothmann Mette Department of Medical Endocrinology, Odense University Hospital, Odense C, Denmark aut NATIONALLICENCE 700 1- Høiberg Mikkel Department of Medical Endocrinology, Oslo University Hospital Aker, Oslo, Norway aut NATIONALLICENCE 700 1- Barkmann Reinhard Section Biomedical Imaging, Department of Radiology and Neuroradiology, University Hospital Schleswig-Holstein, Kiel, Germany aut NATIONALLICENCE 700 1- Gram Jeppe Department of Endocrinology, Hospital of Southwest Denmark, Esbjerg, Denmark aut NATIONALLICENCE 700 1- Hermann Anne Department of Medical Endocrinology, Odense University Hospital, Odense C, Denmark aut NATIONALLICENCE 700 1- Bech Mickael Department of Business and Economics, COHERE, University of Southern Denmark, Odense, Denmark aut NATIONALLICENCE 700 1- Rasmussen Ole Department of Internal Medicine, Sygehus Lillebælt, Kolding, Denmark aut NATIONALLICENCE 700 1- Glüer Claus Section Biomedical Imaging, Department of Radiology and Neuroradiology, University Hospital Schleswig-Holstein, Kiel, Germany aut NATIONALLICENCE 700 1- Brixen Kim Department of Medical Endocrinology, Odense University Hospital, Odense C, Denmark aut NATIONALLICENCE 773 0- Calcified Tissue International Springer US; http://www.springer-ny.com 96/2(2015-02-01), 167-179 0171-967X 96:2<167 2015 96 223