caa a22 4500 605521646 CHVBK 20210128100741.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s00223-014-9940-x doi (NATIONALLICENCE)springer-10.1007/s00223-014-9940-x Risk Factors for the Development of Chronic Back Pain After Percutaneous Vertebroplasty Versus Conservative Treatment [Elektronische Daten] [Pilar Peris, Jordi Blasco, Josep Carrasco, Angels Martinez-Ferrer, Juan Macho, Luis Román, Ana Monegal, Nuria Guañabens] In a recent randomized controlled trial comparing vertebroplasty (VP) versus conservative treatment (CT) in patients with symptomatic vertebral fractures (VF), we observed the development of chronic back pain (CBP) in nearly one-quarter of patients. The aim of this study was to identify the risk factors related to the development of severe CBP in these subjects. We evaluated risk factors including visual analog scale (VAS) at baseline and during the 1-year follow-up, age, gender, symptom onset time, number, type and severity of VF at baseline, number of vertebral bodies treated, incident VF, and antiosteoporotic treatment, among others. CBP was considered in patients with VAS≥7 at 12months. 91/125 patients completed the 12-months follow-up. CBP was observed in 23% of VP-treated patients versus 23% receiving CT. Patients developing CBP after VP showed a longer symptom onset time (82%≥4months in VP vs. 40% in CT, P=0.03). On univariate analysis, female gender (OR 1.52; 95% CI 1.47-1.57, P<0.0001), multiple acute VF (OR 1.79; 95% CI 1.71-1.87, P<0.0001), VAS≥7 two months after treatment (OR 11.04; 95% CI 6.71-18.17, P<0.0001), and type of antiosteoporotic drug (teriparatide) (OR 0.12; 95% CI 0.03-0.60, P=0.0236) were risk factors of CBP development in both groups. In the multivariate analysis, the main risk factors were baseline and post-treatment VAS≥7, longer symptom onset time, and type of antiosteoporotic treatment. In conclusion, 23% of patients with symptomatic osteoporotic VF developed severe CBP independently of the type of treatment. Symptom onset time before VP and persistence of severe CBP after treatment were the main factors related to CBP with teriparatide treatment decreasing the risk of this complication. Springer Science+Business Media New York, 2014 Vertebroplasty nationallicence Vertebral fracture nationallicence Chronic back pain nationallicence Fragility fracture nationallicence Osteoporotic fracture nationallicence Peris Pilar Rheumatology Department, CIBERehd, Hospital Clinic, Villarroel 170, 08036, Barcelona, Spain aut Blasco Jordi Neurointerventional Department, Hospital Clinic, Barcelona, Spain aut Carrasco Josep Public Health Department, University of Barcelona, Barcelona, Spain aut Martinez-Ferrer Angels Rheumatology Department, CIBERehd, Hospital Clinic, Villarroel 170, 08036, Barcelona, Spain aut Macho Juan Neurointerventional Department, Hospital Clinic, Barcelona, Spain aut Román Luis Neurointerventional Department, Hospital Clinic, Barcelona, Spain aut Monegal Ana Rheumatology Department, CIBERehd, Hospital Clinic, Villarroel 170, 08036, Barcelona, Spain aut Guañabens Nuria Rheumatology Department, CIBERehd, Hospital Clinic, Villarroel 170, 08036, Barcelona, Spain aut Calcified Tissue International Springer US; http://www.springer-ny.com 96/2(2015-02-01), 89-96 0171-967X 96:2<89 2015 96 223 https://doi.org/10.1007/s00223-014-9940-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00223-014-9940-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Peris Pilar Rheumatology Department, CIBERehd, Hospital Clinic, Villarroel 170, 08036, Barcelona, Spain aut NATIONALLICENCE 700 1- Blasco Jordi Neurointerventional Department, Hospital Clinic, Barcelona, Spain aut NATIONALLICENCE 700 1- Carrasco Josep Public Health Department, University of Barcelona, Barcelona, Spain aut NATIONALLICENCE 700 1- Martinez-Ferrer Angels Rheumatology Department, CIBERehd, Hospital Clinic, Villarroel 170, 08036, Barcelona, Spain aut NATIONALLICENCE 700 1- Macho Juan Neurointerventional Department, Hospital Clinic, Barcelona, Spain aut NATIONALLICENCE 700 1- Román Luis Neurointerventional Department, Hospital Clinic, Barcelona, Spain aut NATIONALLICENCE 700 1- Monegal Ana Rheumatology Department, CIBERehd, Hospital Clinic, Villarroel 170, 08036, Barcelona, Spain aut NATIONALLICENCE 700 1- Guañabens Nuria Rheumatology Department, CIBERehd, Hospital Clinic, Villarroel 170, 08036, Barcelona, Spain aut NATIONALLICENCE 773 0- Calcified Tissue International Springer US; http://www.springer-ny.com 96/2(2015-02-01), 89-96 0171-967X 96:2<89 2015 96 223