2-Methoxyestradiol and its analogs. Synthesis and structure—antiproliferative activity relationship
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| 024 | 7 | 0 | |a 10.1134/S1070428015090018 |2 doi |
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| 245 | 0 | 0 | |a 2-Methoxyestradiol and its analogs. Synthesis and structure—antiproliferative activity relationship |h [Elektronische Daten] |c [N. Zefirov, O. Zefirova] |
| 520 | 3 | |a 2-Methoxyestradiol is an estradiol metabolite capable of binding to the colchicine domain of the cell protein tubulin. The review systematizes the results of structure—activity studies on 2-methoxyestradiol analogs with various modifications of the A, B, and D rings and describes some synthetic approaches to such analogs. Ways of synthesis of metabolically stable 2-methoxyestradiol via modification of the 3- and 17-hydroxy groups, as well as by introduction of bulky substituents into the 17-position, are discussed. The design of 2-methoxyestradiol analogs lacking steroid fragment is also described. | |
| 540 | |a Pleiades Publishing, Ltd., 2015 | ||
| 700 | 1 | |a Zefirov |D N. |u Faculty of Chemistry, Moscow State University, Leninskie gory 1, 119992, Moscow, Russia |4 aut | |
| 700 | 1 | |a Zefirova |D O. |u Faculty of Chemistry, Moscow State University, Leninskie gory 1, 119992, Moscow, Russia |4 aut | |
| 773 | 0 | |t Russian Journal of Organic Chemistry |d Pleiades Publishing |g 51/9(2015-09-01), 1207-1216 |x 1070-4280 |q 51:9<1207 |1 2015 |2 51 |o 11178 | |
| 856 | 4 | 0 | |u https://doi.org/10.1134/S1070428015090018 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1134/S1070428015090018 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zefirov |D N. |u Faculty of Chemistry, Moscow State University, Leninskie gory 1, 119992, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zefirova |D O. |u Faculty of Chemistry, Moscow State University, Leninskie gory 1, 119992, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Russian Journal of Organic Chemistry |d Pleiades Publishing |g 51/9(2015-09-01), 1207-1216 |x 1070-4280 |q 51:9<1207 |1 2015 |2 51 |o 11178 | ||