caa a22 4500 605529108 CHVBK 20210128100816.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1134/S1070428015090018 doi (NATIONALLICENCE)springer-10.1134/S1070428015090018 2-Methoxyestradiol and its analogs. Synthesis and structure—antiproliferative activity relationship [Elektronische Daten] [N. Zefirov, O. Zefirova] 2-Methoxyestradiol is an estradiol metabolite capable of binding to the colchicine domain of the cell protein tubulin. The review systematizes the results of structure—activity studies on 2-methoxyestradiol analogs with various modifications of the A, B, and D rings and describes some synthetic approaches to such analogs. Ways of synthesis of metabolically stable 2-methoxyestradiol via modification of the 3- and 17-hydroxy groups, as well as by introduction of bulky substituents into the 17-position, are discussed. The design of 2-methoxyestradiol analogs lacking steroid fragment is also described. Pleiades Publishing, Ltd., 2015 Zefirov N. Faculty of Chemistry, Moscow State University, Leninskie gory 1, 119992, Moscow, Russia aut Zefirova O. Faculty of Chemistry, Moscow State University, Leninskie gory 1, 119992, Moscow, Russia aut Russian Journal of Organic Chemistry Pleiades Publishing 51/9(2015-09-01), 1207-1216 1070-4280 51:9<1207 2015 51 11178 https://doi.org/10.1134/S1070428015090018 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1134/S1070428015090018 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zefirov N. Faculty of Chemistry, Moscow State University, Leninskie gory 1, 119992, Moscow, Russia aut NATIONALLICENCE 700 1- Zefirova O. Faculty of Chemistry, Moscow State University, Leninskie gory 1, 119992, Moscow, Russia aut NATIONALLICENCE 773 0- Russian Journal of Organic Chemistry Pleiades Publishing 51/9(2015-09-01), 1207-1216 1070-4280 51:9<1207 2015 51 11178