Reaction of 6-chloropyrimidine-2,4(1 H ,3 H )-dione with 2-(chloromethoxy)ethyl benzoate. Synthesis of new acyclic nucleosides
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| 024 | 7 | 0 | |a 10.1134/S1070428015030124 |2 doi |
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| 245 | 0 | 0 | |a Reaction of 6-chloropyrimidine-2,4(1 H ,3 H )-dione with 2-(chloromethoxy)ethyl benzoate. Synthesis of new acyclic nucleosides |h [Elektronische Daten] |c [R. Melik-Ohanjanyan, T. Hovsepyan, S. Israelyan, M. Ghukasyan, G. Karakhanyan, H. Panosyan, R. Tamazyan, A. Ayvazyan] |
| 520 | 3 | |a New acyclic pyrimidine nucleosides, analogs of the antiviral drug acyclovir, were synthesized starting from 6-chloropyrimidine-2,4(1H,3H)-dione. The addition of side carbohydrate chain to the N1 or N3 atoms of the heterocyclic base with formation of N1- and N3-substituted isomers, respectively, was confirmed by 1H NMR and X-ray analysis. N1- and N3-Substituted 6-chloropyrimidine-2,4(1H,3H)-diones were subjected to amination with secondary amines, and cyclocondensation of 6-allylamino derivative afforded N1-substituted pyrido[2,3-d]pyrimidine. | |
| 540 | |a Pleiades Publishing, Ltd., 2015 | ||
| 700 | 1 | |a Melik-Ohanjanyan |D R. |u Mndzhoyan Institute of Fine Organic Chemistry, Scientific-Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, pr. Azatutyan 26, 0014, Yerevan, Armenia |4 aut | |
| 700 | 1 | |a Hovsepyan |D T. |u Mndzhoyan Institute of Fine Organic Chemistry, Scientific-Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, pr. Azatutyan 26, 0014, Yerevan, Armenia |4 aut | |
| 700 | 1 | |a Israelyan |D S. |u Mndzhoyan Institute of Fine Organic Chemistry, Scientific-Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, pr. Azatutyan 26, 0014, Yerevan, Armenia |4 aut | |
| 700 | 1 | |a Ghukasyan |D M. |u Mndzhoyan Institute of Fine Organic Chemistry, Scientific-Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, pr. Azatutyan 26, 0014, Yerevan, Armenia |4 aut | |
| 700 | 1 | |a Karakhanyan |D G. |u Mndzhoyan Institute of Fine Organic Chemistry, Scientific-Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, pr. Azatutyan 26, 0014, Yerevan, Armenia |4 aut | |
| 700 | 1 | |a Panosyan |D H. |u Molecular Structure Research Center, Scientific-Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, pr. Azatutyan 26, 0014, Yerevan, Armenia |4 aut | |
| 700 | 1 | |a Tamazyan |D R. |u Molecular Structure Research Center, Scientific-Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, pr. Azatutyan 26, 0014, Yerevan, Armenia |4 aut | |
| 700 | 1 | |a Ayvazyan |D A. |u Molecular Structure Research Center, Scientific-Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, pr. Azatutyan 26, 0014, Yerevan, Armenia |4 aut | |
| 773 | 0 | |t Russian Journal of Organic Chemistry |d Pleiades Publishing |g 51/3(2015-03-01), 361-367 |x 1070-4280 |q 51:3<361 |1 2015 |2 51 |o 11178 | |
| 856 | 4 | 0 | |u https://doi.org/10.1134/S1070428015030124 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1134/S1070428015030124 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Melik-Ohanjanyan |D R. |u Mndzhoyan Institute of Fine Organic Chemistry, Scientific-Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, pr. Azatutyan 26, 0014, Yerevan, Armenia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Hovsepyan |D T. |u Mndzhoyan Institute of Fine Organic Chemistry, Scientific-Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, pr. Azatutyan 26, 0014, Yerevan, Armenia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Israelyan |D S. |u Mndzhoyan Institute of Fine Organic Chemistry, Scientific-Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, pr. Azatutyan 26, 0014, Yerevan, Armenia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ghukasyan |D M. |u Mndzhoyan Institute of Fine Organic Chemistry, Scientific-Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, pr. Azatutyan 26, 0014, Yerevan, Armenia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Karakhanyan |D G. |u Mndzhoyan Institute of Fine Organic Chemistry, Scientific-Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, pr. Azatutyan 26, 0014, Yerevan, Armenia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Panosyan |D H. |u Molecular Structure Research Center, Scientific-Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, pr. Azatutyan 26, 0014, Yerevan, Armenia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Tamazyan |D R. |u Molecular Structure Research Center, Scientific-Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, pr. Azatutyan 26, 0014, Yerevan, Armenia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ayvazyan |D A. |u Molecular Structure Research Center, Scientific-Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, pr. Azatutyan 26, 0014, Yerevan, Armenia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Russian Journal of Organic Chemistry |d Pleiades Publishing |g 51/3(2015-03-01), 361-367 |x 1070-4280 |q 51:3<361 |1 2015 |2 51 |o 11178 | ||