New synthesis of syn -stereodiad building block for polyketides. Formal synthesis of arenamides A and C
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| 024 | 7 | 0 | |a 10.1134/S107042801504020X |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1134/S107042801504020X | ||
| 100 | 1 | |a Shklyaruck |D D. |u Belarusian State University, pr. Nezavisimosti 4, 220030, Minsk, Belarus |4 aut | |
| 245 | 1 | 0 | |a New synthesis of syn -stereodiad building block for polyketides. Formal synthesis of arenamides A and C |h [Elektronische Daten] |c [D. Shklyaruck] |
| 520 | 3 | |a An efficient procedure has been developed for the transformation of (7S)-7-(3-bromoprop-1-en-2-yl)-5,5-dimethyl-4,6-dioxaspiro[2.5]octane [available from diethyl (S)-malate] into methyl 2-[(4S)-2,2-dimethyl-5-methylidene-1,3-dioxan-4-yl]acetate, and conditions for diastereoselective reduction of the double C=C bond in the latter have been optimized. The reduction product has been converted into (3S,4S)-3-[tert-butyl(dimethyl)siloxy]-4-methyldecanoic acid which is a building block for the synthesis of arenamides A and C, natural compounds possessing pronounced antitumor activity and efficiently inhibiting nitrogen(II) oxide and prostaglandin E2 (PGE2). | |
| 540 | |a Pleiades Publishing, Ltd., 2015 | ||
| 773 | 0 | |t Russian Journal of Organic Chemistry |d Pleiades Publishing |g 51/4(2015-04-01), 582-590 |x 1070-4280 |q 51:4<582 |1 2015 |2 51 |o 11178 | |
| 856 | 4 | 0 | |u https://doi.org/10.1134/S107042801504020X |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1134/S107042801504020X |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 100 |E 1- |a Shklyaruck |D D. |u Belarusian State University, pr. Nezavisimosti 4, 220030, Minsk, Belarus |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Russian Journal of Organic Chemistry |d Pleiades Publishing |g 51/4(2015-04-01), 582-590 |x 1070-4280 |q 51:4<582 |1 2015 |2 51 |o 11178 | ||