Alternative synthesis of thiazole-substituted fragment C10-C21 of epothilone D analog

Verfasser / Beitragende:
[R. Valeev, R. Bikzhanov, M. Miftakhov]
Ort, Verlag, Jahr:
2015
Enthalten in:
Russian Journal of Organic Chemistry, 51/5(2015-05-01), 660-663
Format:
Artikel (online)
ID: 605530742
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245 0 0 |a Alternative synthesis of thiazole-substituted fragment C10-C21 of epothilone D analog  |h [Elektronische Daten]  |c [R. Valeev, R. Bikzhanov, M. Miftakhov] 
520 3 |a New procedure was developed for preparation of the fragment C10-C21 of epothilone D analog from R-(-)-carvone. The key stage of the synthesis consists in the regio- and stereoselective Wittig reaction of (5R)-5-acetyl-2-methylcyclohex-2-en-1-one with an ylide generated from tributyl[(2-methylthiazol-4-yl)methyl]-phosphonium chloride. 
540 |a Pleiades Publishing, Ltd., 2015 
700 1 |a Valeev  |D R.  |u Ufa Institute of Chemistry, Russian Academy of Sciences, pr. Oktyabrya 71, 450054, Ufa, Russia  |4 aut 
700 1 |a Bikzhanov  |D R.  |u Ufa Institute of Chemistry, Russian Academy of Sciences, pr. Oktyabrya 71, 450054, Ufa, Russia  |4 aut 
700 1 |a Miftakhov  |D M.  |u Ufa Institute of Chemistry, Russian Academy of Sciences, pr. Oktyabrya 71, 450054, Ufa, Russia  |4 aut 
773 0 |t Russian Journal of Organic Chemistry  |d Pleiades Publishing  |g 51/5(2015-05-01), 660-663  |x 1070-4280  |q 51:5<660  |1 2015  |2 51  |o 11178 
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950 |B NATIONALLICENCE  |P 700  |E 1-  |a Valeev  |D R.  |u Ufa Institute of Chemistry, Russian Academy of Sciences, pr. Oktyabrya 71, 450054, Ufa, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Bikzhanov  |D R.  |u Ufa Institute of Chemistry, Russian Academy of Sciences, pr. Oktyabrya 71, 450054, Ufa, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Miftakhov  |D M.  |u Ufa Institute of Chemistry, Russian Academy of Sciences, pr. Oktyabrya 71, 450054, Ufa, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 773  |E 0-  |t Russian Journal of Organic Chemistry  |d Pleiades Publishing  |g 51/5(2015-05-01), 660-663  |x 1070-4280  |q 51:5<660  |1 2015  |2 51  |o 11178