Quantitative characterization of circadian rhythm of pulmonary function in asthmatic patients treated with inhaled corticosteroids
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| 024 | 7 | 0 | |a 10.1007/s10928-015-9420-6 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10928-015-9420-6 | ||
| 245 | 0 | 0 | |a Quantitative characterization of circadian rhythm of pulmonary function in asthmatic patients treated with inhaled corticosteroids |h [Elektronische Daten] |c [Di Zhou, Hongshan Li, Yaning Wang, Guenther Hochhaus, Vikram Sinha, Liang Zhao] |
| 520 | 3 | |a The aim of this study was to characterize the circadian rhythm observed for forced expiratory volume in 1s (FEV1) in patients with persistent asthma being treated with inhaled corticosteroids. The database included 3379 FEV1 measurements from 189 patients with mild to moderate asthma. A model using the sum of two Sine functions with periods of 12 and 24h and a constant component of mean circadian rhythm adequately described the circadian rhythm in FEV1 measurements over time. The model adequateness was evaluated by various approaches including visual predictive check (VPC), prediction-corrected VPC, standardized VPC and normalized prediction distribution error. Covariates tested included age, body weight, height, body mass index, baseline FEV1, and sex. Age and height were found to have significant effects on the mean FEV1 level and no covariate was found to have an effect on the magnitude and timing of circadian rhythm. The model predicted that a minimum FEV1 occurred in the early morning and maximum FEV1 occurred in the early afternoon, with a population mean fluctuation of 170mL, which is consistent with the finding that asthma symptoms usually exacerbate in the early morning for patients with persistent asthma. This developed model provides the first quantitative approach to describing FEV1 circadian rhythm with ICS background treatment and provided insight in designing future registration trials for asthma drug development. | |
| 540 | |a Springer Science+Business Media New York (outside the USA), 2015 | ||
| 690 | 7 | |a Circadian rhythm |2 nationallicence | |
| 690 | 7 | |a Asthma |2 nationallicence | |
| 690 | 7 | |a FEV1 |2 nationallicence | |
| 690 | 7 | |a Pharmacodynamic model |2 nationallicence | |
| 690 | 7 | |a Drug development |2 nationallicence | |
| 700 | 1 | |a Zhou |D Di |u Department of Pharmaceutics, College of Pharmacy, University of Florida, 1600 SW Archer Road, Gainesville, FL, USA |4 aut | |
| 700 | 1 | |a Li |D Hongshan |u Office of Clinical Pharmacology, Office of Translational Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA |4 aut | |
| 700 | 1 | |a Wang |D Yaning |u Office of Clinical Pharmacology, Office of Translational Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA |4 aut | |
| 700 | 1 | |a Hochhaus |D Guenther |u Department of Pharmaceutics, College of Pharmacy, University of Florida, 1600 SW Archer Road, Gainesville, FL, USA |4 aut | |
| 700 | 1 | |a Sinha |D Vikram |u Office of Clinical Pharmacology, Office of Translational Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA |4 aut | |
| 700 | 1 | |a Zhao |D Liang |u Office of Clinical Pharmacology, Office of Translational Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA |4 aut | |
| 773 | 0 | |t Journal of Pharmacokinetics and Pharmacodynamics |d Springer US; http://www.springer-ny.com |g 42/4(2015-08-01), 391-399 |x 1567-567X |q 42:4<391 |1 2015 |2 42 |o 10928 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10928-015-9420-6 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10928-015-9420-6 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zhou |D Di |u Department of Pharmaceutics, College of Pharmacy, University of Florida, 1600 SW Archer Road, Gainesville, FL, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Li |D Hongshan |u Office of Clinical Pharmacology, Office of Translational Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Wang |D Yaning |u Office of Clinical Pharmacology, Office of Translational Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Hochhaus |D Guenther |u Department of Pharmaceutics, College of Pharmacy, University of Florida, 1600 SW Archer Road, Gainesville, FL, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sinha |D Vikram |u Office of Clinical Pharmacology, Office of Translational Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zhao |D Liang |u Office of Clinical Pharmacology, Office of Translational Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Journal of Pharmacokinetics and Pharmacodynamics |d Springer US; http://www.springer-ny.com |g 42/4(2015-08-01), 391-399 |x 1567-567X |q 42:4<391 |1 2015 |2 42 |o 10928 | ||