caa a22 4500 605534160 CHVBK 20210128100841.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s10928-015-9405-5 doi (NATIONALLICENCE)springer-10.1007/s10928-015-9405-5 Usefulness of permutation entropy as an anesthetic depth indicator in children [Elektronische Daten] [Pil-Jong Kim, Hong-Gee Kim, Gyu-Jeong Noh, Yong-Seo Koo, Teo Shin] Permutation entropy (PE) as a complexity measure has been introduced to monitor anesthetic depth for adult. However, PE has not yet been evaluated for its clinical applicability as an indicator of anesthetic depth in children. Therefore, in order to investigate the validity of PE, we compared PE with BIS using pharmacodynamic (PD) modeling in children. Electroencephalogram (EEG) was obtained from BIS monitor during sevoflurane deepening and lightening protocol. End-tidal sevoflurane concentration (Etsevo) and BIS were measured simultaneously. PE was calculated from the processed EEG with the scale ranging from 0 to 100. NONMEM software was used to investigate the PD relationship between Etsevo with BIS and PE. Adjusted PE (APE) values were decreased as anesthesia deepened. APE and BIS showed significant linear correlation (P<0.001), indicating that PE also reflects anesthesia depth. PD parameters for APE and BIS were estimated with a sigmoid Emax model which describes the relationship between Etsevo and APE/BIS (E o : 78, E max : 17.6, C e50 : 2.5 vol%; γ: 13.1, k eo : 0.47min−1 for APE; E o : 89.4; E max : 15.7; C e50 : 2.2 vol%; γ: 6.6, keo: 0.52min−1 for BIS). PE seems to be a useful indicator of anesthetic depth, which is comparable to BIS in children. Springer Science+Business Media New York, 2015 Anesthesia nationallicence Entropy nationallicence NONMEM nationallicence Sevoflurane nationallicence Kim Pil-Jong Biomedical Knowledge Engineering Laboratory, School of Dentistry, Seoul National University, 28 Yeongeon-dong Jongno-gu, Seoul, Republic of Korea aut Kim Hong-Gee Biomedical Knowledge Engineering Laboratory, School of Dentistry, Seoul National University, 28 Yeongeon-dong Jongno-gu, Seoul, Republic of Korea aut Noh Gyu-Jeong Department of Clinical Pharmacology and Therapeutics/Anesthesiology and Pain Medicine, Asan Medical Centre, University of Ulsan College of Medicine, Seoul, Republic of Korea aut Koo Yong-Seo Department of Neurology, Korea University College of Medicine, Seoul, Republic of Korea aut Shin Teo Department of Pediatric Dentistry and Dental Research Institute, School of Dentistry, Seoul National University, 28 Yeongeon-dong Jongno-gu, 110-768, Seoul, Republic of Korea aut Journal of Pharmacokinetics and Pharmacodynamics Springer US; http://www.springer-ny.com 42/2(2015-04-01), 123-134 1567-567X 42:2<123 2015 42 10928 https://doi.org/10.1007/s10928-015-9405-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10928-015-9405-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kim Pil-Jong Biomedical Knowledge Engineering Laboratory, School of Dentistry, Seoul National University, 28 Yeongeon-dong Jongno-gu, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Kim Hong-Gee Biomedical Knowledge Engineering Laboratory, School of Dentistry, Seoul National University, 28 Yeongeon-dong Jongno-gu, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Noh Gyu-Jeong Department of Clinical Pharmacology and Therapeutics/Anesthesiology and Pain Medicine, Asan Medical Centre, University of Ulsan College of Medicine, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Koo Yong-Seo Department of Neurology, Korea University College of Medicine, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Shin Teo Department of Pediatric Dentistry and Dental Research Institute, School of Dentistry, Seoul National University, 28 Yeongeon-dong Jongno-gu, 110-768, Seoul, Republic of Korea aut NATIONALLICENCE 773 0- Journal of Pharmacokinetics and Pharmacodynamics Springer US; http://www.springer-ny.com 42/2(2015-04-01), 123-134 1567-567X 42:2<123 2015 42 10928