Integrated PK-PD and agent-based modeling in oncology
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| 024 | 7 | 0 | |a 10.1007/s10928-015-9403-7 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10928-015-9403-7 | ||
| 245 | 0 | 0 | |a Integrated PK-PD and agent-based modeling in oncology |h [Elektronische Daten] |c [Zhihui Wang, Joseph Butner, Vittorio Cristini, Thomas Deisboeck] |
| 520 | 3 | |a Mathematical modeling has become a valuable tool that strives to complement conventional biomedical research modalities in order to predict experimental outcome, generate new medical hypotheses, and optimize clinical therapies. Two specific approaches, pharmacokinetic-pharmacodynamic (PK-PD) modeling, and agent-based modeling (ABM), have been widely applied in cancer research. While they have made important contributions on their own (e.g., PK-PD in examining chemotherapy drug efficacy and resistance, and ABM in describing and predicting tumor growth and metastasis), only a few groups have started to combine both approaches together in an effort to gain more insights into the details of drug dynamics and the resulting impact on tumor growth. In this review, we focus our discussion on some of the most recent modeling studies building on a combined PK-PD and ABM approach that have generated experimentally testable hypotheses. Some future directions are also discussed. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a Chemotherapy |2 nationallicence | |
| 690 | 7 | |a Computer simulation |2 nationallicence | |
| 690 | 7 | |a Mathematical modeling |2 nationallicence | |
| 690 | 7 | |a Multiscale |2 nationallicence | |
| 690 | 7 | |a Tumor growth and invasion |2 nationallicence | |
| 690 | 7 | |a Translational research |2 nationallicence | |
| 700 | 1 | |a Wang |D Zhihui |u Department of Pathology, University of New Mexico, 87131, Albuquerque, NM, USA |4 aut | |
| 700 | 1 | |a Butner |D Joseph |u Department of Chemical Engineering and Center for Biomedical Engineering, University of New Mexico, 87131, Albuquerque, NM, USA |4 aut | |
| 700 | 1 | |a Cristini |D Vittorio |u Department of Pathology, University of New Mexico, 87131, Albuquerque, NM, USA |4 aut | |
| 700 | 1 | |a Deisboeck |D Thomas |u Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 02129, Charlestown, MA, USA |4 aut | |
| 773 | 0 | |t Journal of Pharmacokinetics and Pharmacodynamics |d Springer US; http://www.springer-ny.com |g 42/2(2015-04-01), 179-189 |x 1567-567X |q 42:2<179 |1 2015 |2 42 |o 10928 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10928-015-9403-7 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a review-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10928-015-9403-7 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Wang |D Zhihui |u Department of Pathology, University of New Mexico, 87131, Albuquerque, NM, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Butner |D Joseph |u Department of Chemical Engineering and Center for Biomedical Engineering, University of New Mexico, 87131, Albuquerque, NM, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Cristini |D Vittorio |u Department of Pathology, University of New Mexico, 87131, Albuquerque, NM, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Deisboeck |D Thomas |u Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 02129, Charlestown, MA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Journal of Pharmacokinetics and Pharmacodynamics |d Springer US; http://www.springer-ny.com |g 42/2(2015-04-01), 179-189 |x 1567-567X |q 42:2<179 |1 2015 |2 42 |o 10928 | ||