caa a22 4500 605534187 CHVBK 20210128100841.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s10928-015-9403-7 doi (NATIONALLICENCE)springer-10.1007/s10928-015-9403-7 Integrated PK-PD and agent-based modeling in oncology [Elektronische Daten] [Zhihui Wang, Joseph Butner, Vittorio Cristini, Thomas Deisboeck] Mathematical modeling has become a valuable tool that strives to complement conventional biomedical research modalities in order to predict experimental outcome, generate new medical hypotheses, and optimize clinical therapies. Two specific approaches, pharmacokinetic-pharmacodynamic (PK-PD) modeling, and agent-based modeling (ABM), have been widely applied in cancer research. While they have made important contributions on their own (e.g., PK-PD in examining chemotherapy drug efficacy and resistance, and ABM in describing and predicting tumor growth and metastasis), only a few groups have started to combine both approaches together in an effort to gain more insights into the details of drug dynamics and the resulting impact on tumor growth. In this review, we focus our discussion on some of the most recent modeling studies building on a combined PK-PD and ABM approach that have generated experimentally testable hypotheses. Some future directions are also discussed. Springer Science+Business Media New York, 2015 Chemotherapy nationallicence Computer simulation nationallicence Mathematical modeling nationallicence Multiscale nationallicence Tumor growth and invasion nationallicence Translational research nationallicence Wang Zhihui Department of Pathology, University of New Mexico, 87131, Albuquerque, NM, USA aut Butner Joseph Department of Chemical Engineering and Center for Biomedical Engineering, University of New Mexico, 87131, Albuquerque, NM, USA aut Cristini Vittorio Department of Pathology, University of New Mexico, 87131, Albuquerque, NM, USA aut Deisboeck Thomas Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 02129, Charlestown, MA, USA aut Journal of Pharmacokinetics and Pharmacodynamics Springer US; http://www.springer-ny.com 42/2(2015-04-01), 179-189 1567-567X 42:2<179 2015 42 10928 https://doi.org/10.1007/s10928-015-9403-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10928-015-9403-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wang Zhihui Department of Pathology, University of New Mexico, 87131, Albuquerque, NM, USA aut NATIONALLICENCE 700 1- Butner Joseph Department of Chemical Engineering and Center for Biomedical Engineering, University of New Mexico, 87131, Albuquerque, NM, USA aut NATIONALLICENCE 700 1- Cristini Vittorio Department of Pathology, University of New Mexico, 87131, Albuquerque, NM, USA aut NATIONALLICENCE 700 1- Deisboeck Thomas Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 02129, Charlestown, MA, USA aut NATIONALLICENCE 773 0- Journal of Pharmacokinetics and Pharmacodynamics Springer US; http://www.springer-ny.com 42/2(2015-04-01), 179-189 1567-567X 42:2<179 2015 42 10928