Population pharmacokinetic and pharmacodynamic model of propofol externally validated in children
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| 024 | 7 | 0 | |a 10.1007/s10928-015-9408-2 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10928-015-9408-2 | ||
| 245 | 0 | 0 | |a Population pharmacokinetic and pharmacodynamic model of propofol externally validated in children |h [Elektronische Daten] |c [Byung-Moon Choi, Hyun-Gu Lee, Hyo-Jin Byon, Soo-Han Lee, Eun-Kyung Lee, Hee-Soo Kim, Gyu-Jeong Noh] |
| 520 | 3 | |a There have been no pharmacokinetic parameters and blood-brain equilibration rate constant (k e0) of propofol obtained in a single population of children, by which propofol can be administered using a target effect-site concentration controlled infusion. Thirty-nine, American Society of Anesthesiologists Physical Status 1-2 children aged 2-12years were given an intravenous bolus of propofol (3mgkg−1), followed by infusion (200µgkg−1min−1). Arterial drug concentrations and bispectral index (BIS) values were measured. Population pharmacokinetic and pharmacodynamic analysis was performed using nonlinear mixed effects modeling. External model validation was performed in a separate population of children. A two-compartment model and a sigmoid E max model directly linked by an effect compartment well described the time courses of propofol concentration and BIS. The estimates of parameters were: V 1 (L)=1.69, V 2 (L)=27.2+0.929×(weight−25), Cl (Lmin−1)=0.893×(weight/23.6)0.966, Q (Lmin−1)=1.3; E 0=76.9; E max =35.4, Ce 50 (μgmL−1)=3.47−(0.095×age)−(1.63×mean infusion rate of remifentanil in µgkg−1min−1); γ=2.1; and k e0 (min−1)=0.371. Pooled biases (95% CI) of the target effect-site concentration controlled infusion system of propofol was −20.2% (−23.3 to −18.1%) and pooled inaccuracy was 30.4% (28.6-32.7%). Pooled biases of BIS prediction was −6.8% (−9.1 to −4.1%) and pooled inaccuracies was 19.1% (17.5-20.9%).The altered weight-based dose requirements of propofol are well described pharmacokinetically, and pharmacodynamically. Predictive performances of the TCI system in this study were clinically acceptable. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a Propofol |2 nationallicence | |
| 690 | 7 | |a Pharmacokinetics |2 nationallicence | |
| 690 | 7 | |a Pharmacodynamics |2 nationallicence | |
| 700 | 1 | |a Choi |D Byung-Moon |u Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap 2-dong, Songpa-gu, 138-736, Seoul, Korea |4 aut | |
| 700 | 1 | |a Lee |D Hyun-Gu |u University of Ulsan College of Medicine, Seoul, Korea |4 aut | |
| 700 | 1 | |a Byon |D Hyo-Jin |u Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, Korea |4 aut | |
| 700 | 1 | |a Lee |D Soo-Han |u Department of Clinical Pharmacology and Therapeutics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea |4 aut | |
| 700 | 1 | |a Lee |D Eun-Kyung |u Department of Statistics, Ewha Womans University, Seoul, Korea |4 aut | |
| 700 | 1 | |a Kim |D Hee-Soo |u Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, Korea |4 aut | |
| 700 | 1 | |a Noh |D Gyu-Jeong |u Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap 2-dong, Songpa-gu, 138-736, Seoul, Korea |4 aut | |
| 773 | 0 | |t Journal of Pharmacokinetics and Pharmacodynamics |d Springer US; http://www.springer-ny.com |g 42/2(2015-04-01), 163-177 |x 1567-567X |q 42:2<163 |1 2015 |2 42 |o 10928 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10928-015-9408-2 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10928-015-9408-2 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Choi |D Byung-Moon |u Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap 2-dong, Songpa-gu, 138-736, Seoul, Korea |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Lee |D Hyun-Gu |u University of Ulsan College of Medicine, Seoul, Korea |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Byon |D Hyo-Jin |u Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, Korea |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Lee |D Soo-Han |u Department of Clinical Pharmacology and Therapeutics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Lee |D Eun-Kyung |u Department of Statistics, Ewha Womans University, Seoul, Korea |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kim |D Hee-Soo |u Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, Korea |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Noh |D Gyu-Jeong |u Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap 2-dong, Songpa-gu, 138-736, Seoul, Korea |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Journal of Pharmacokinetics and Pharmacodynamics |d Springer US; http://www.springer-ny.com |g 42/2(2015-04-01), 163-177 |x 1567-567X |q 42:2<163 |1 2015 |2 42 |o 10928 | ||