caa a22 4500 605534691 CHVBK 20210128100844.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s10517-015-2877-x doi (NATIONALLICENCE)springer-10.1007/s10517-015-2877-x Electrical Rhythms Revealed by Harmonic Analysis of a High-Resolution Cardiogram [Elektronische Daten] [S. Revenko, L. Selector, I. Gavrilov, A. Nesterov, E. Limonov, I. Mudraya, V. Kirpatovskii] The front-end low-noise electronic amplifiers and high-throughput computing systems made it possible to record ECG with a high resolution in the low-frequency range including the respiration and Mayer frequencies and to analyze ECG with digital filtering technique and harmonic analysis. These tools yielded ECG spectra of narcotized rats, which contained the characteristic pulsatile triplets and pentaplets with splitting constant equal to respiration rate, as well as the peaks at respiration and Mayer frequencies. The harmonic analysis of ECG determined the frequency parameters employed to tune the software bandpass filters, which revealed the respiratory (R) and Mayer (M) waves in the time domain with the amplitudes of 20-30 μV amounting to 5% ECG amplitude. The depolarizing myorelaxant succinylcholine chloride capable to trigger various types of arrhythmias, transiently increased R-wave, inhibited M-wave, and provoked a negative U-wave within a heartbeat ECG cycle synchronously with inspiration. It is hypothesized that M-, R-, and U-waves in ECG reflect cardiotropic activity of autonomic nervous system. The respective spectral peaks in ECG can be employed to assess intensity of sympathetic and parasympathetic cardiotropic influences, their balance, and the risk of arrhythmias. Springer Science+Business Media New York, 2015 harmonic analysis of electrocardiogram nationallicence Mayer wave nationallicence respiratory wave nationallicence Uwave nationallicence succinylcholine chloride nationallicence Revenko S. Department of Physiology, Russian Cardiology Research-and-Development Center, Ministry of Health of the Russian Federation, Moscow, Russia aut Selector L. Department of Physiology, Russian Cardiology Research-and-Development Center, Ministry of Health of the Russian Federation, Moscow, Russia aut Gavrilov I. BIOLA Research-and-Production Company, Moscow, Russia aut Nesterov A. BIOLA Research-and-Production Company, Moscow, Russia aut Limonov E. BIOLA Research-and-Production Company, Moscow, Russia aut Mudraya I. Department of Experimental Modeling of Urological Diseases, Research Institute of Urology, Ministry of Health of the Russian Federation, Moscow, Russia aut Kirpatovskii V. Department of Experimental Modeling of Urological Diseases, Research Institute of Urology, Ministry of Health of the Russian Federation, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/1(2015-05-01), 11-15 0007-4888 159:1<11 2015 159 10517 https://doi.org/10.1007/s10517-015-2877-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2877-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Revenko S. Department of Physiology, Russian Cardiology Research-and-Development Center, Ministry of Health of the Russian Federation, Moscow, Russia aut NATIONALLICENCE 700 1- Selector L. Department of Physiology, Russian Cardiology Research-and-Development Center, Ministry of Health of the Russian Federation, Moscow, Russia aut NATIONALLICENCE 700 1- Gavrilov I. BIOLA Research-and-Production Company, Moscow, Russia aut NATIONALLICENCE 700 1- Nesterov A. BIOLA Research-and-Production Company, Moscow, Russia aut NATIONALLICENCE 700 1- Limonov E. BIOLA Research-and-Production Company, Moscow, Russia aut NATIONALLICENCE 700 1- Mudraya I. Department of Experimental Modeling of Urological Diseases, Research Institute of Urology, Ministry of Health of the Russian Federation, Moscow, Russia aut NATIONALLICENCE 700 1- Kirpatovskii V. Department of Experimental Modeling of Urological Diseases, Research Institute of Urology, Ministry of Health of the Russian Federation, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/1(2015-05-01), 11-15 0007-4888 159:1<11 2015 159 10517