Long-Term Changes in Proliferative Capacity of Thymocytes and Splenocytes in Mouse Progeny after Stimulation of Maternal Lymphocyte Proliferation at Early Terms of Pregnancy
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| 024 | 7 | 0 | |a 10.1007/s10517-015-2912-y |2 doi |
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| 245 | 0 | 0 | |a Long-Term Changes in Proliferative Capacity of Thymocytes and Splenocytes in Mouse Progeny after Stimulation of Maternal Lymphocyte Proliferation at Early Terms of Pregnancy |h [Elektronische Daten] |c [N. Yaglova, S. Obernikhin] |
| 520 | 3 | |a We studied the possibility of prenatal programming of proliferative potential of thymocytes and splenocytes in the offspring of C57Bl/6 mice via concanavalin A mitogen stimulation of lymphocyte proliferation in maternal organism at the early terms of pregnancy before the formation of immune system organs in the embryo. The offspring demonstrated elevated proliferative activity of thymocytes and splenocytes, enhanced lymphocyte proliferation, and increased production of IL-2 in in vitro response to concanavalin A during the prepubertal period and puberty. Mitogen stimulation of the maternal immune system in early pregnancy results in long-term enhancement of the proliferative potential of thymus and splenic cells in the offspring. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a prenatal exposure |2 nationallicence | |
| 690 | 7 | |a proliferation |2 nationallicence | |
| 690 | 7 | |a thymus |2 nationallicence | |
| 690 | 7 | |a spleen |2 nationallicence | |
| 700 | 1 | |a Yaglova |D N. |u Research Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow, Russia |4 aut | |
| 700 | 1 | |a Obernikhin |D S. |u Research Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/1(2015-05-01), 152-156 |x 0007-4888 |q 159:1<152 |1 2015 |2 159 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-2912-y |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-2912-y |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yaglova |D N. |u Research Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Obernikhin |D S. |u Research Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/1(2015-05-01), 152-156 |x 0007-4888 |q 159:1<152 |1 2015 |2 159 |o 10517 | ||