caa a22 4500 605534713 CHVBK 20210128100844.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s10517-015-2912-y doi (NATIONALLICENCE)springer-10.1007/s10517-015-2912-y Long-Term Changes in Proliferative Capacity of Thymocytes and Splenocytes in Mouse Progeny after Stimulation of Maternal Lymphocyte Proliferation at Early Terms of Pregnancy [Elektronische Daten] [N. Yaglova, S. Obernikhin] We studied the possibility of prenatal programming of proliferative potential of thymocytes and splenocytes in the offspring of C57Bl/6 mice via concanavalin A mitogen stimulation of lymphocyte proliferation in maternal organism at the early terms of pregnancy before the formation of immune system organs in the embryo. The offspring demonstrated elevated proliferative activity of thymocytes and splenocytes, enhanced lymphocyte proliferation, and increased production of IL-2 in in vitro response to concanavalin A during the prepubertal period and puberty. Mitogen stimulation of the maternal immune system in early pregnancy results in long-term enhancement of the proliferative potential of thymus and splenic cells in the offspring. Springer Science+Business Media New York, 2015 prenatal exposure nationallicence proliferation nationallicence thymus nationallicence spleen nationallicence Yaglova N. Research Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow, Russia aut Obernikhin S. Research Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/1(2015-05-01), 152-156 0007-4888 159:1<152 2015 159 10517 https://doi.org/10.1007/s10517-015-2912-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2912-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yaglova N. Research Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Obernikhin S. Research Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/1(2015-05-01), 152-156 0007-4888 159:1<152 2015 159 10517