Functionally Active Gap Junctions between Connexin 43-Positive Mesenchymal Stem Cells and Glioma Cells
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| 024 | 7 | 0 | |a 10.1007/s10517-015-2916-7 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10517-015-2916-7 | ||
| 245 | 0 | 0 | |a Functionally Active Gap Junctions between Connexin 43-Positive Mesenchymal Stem Cells and Glioma Cells |h [Elektronische Daten] |c [A. Gabashvili, V. Baklaushev, N. Grinenko, A. Levinskii, P. Mel'nikov, S. Cherepanov, V. Chekhonin] |
| 520 | 3 | |a The formation of functional gap junctions between mesenchymal stem cells and cells of low-grade rat glioma C6 cells was studied in in vitro experiments. Immunocytochemical analysis with antibodies to connexin 43 extracellular loop 2 showed that mesenchymal stem cells as well as C6 glioma cells express the main astroglial gap junction protein connexin 43. Analysis of migration activity showed that mesenchymal stem cells actively migrate towards C6 glioma cells. During co-culturing, mesenchymal stem cells and glioma C6 form functionally active gap junctions mediating the transport of cytoplasmic dye from glioma cells to mesenchymal stem cells in the opposite direction. Fluorometry showed that the intensity of transport of low-molecular substances through heterologous gap junctions between mesenchymal stem cells and glioma cells is similar to that through homologous gap junctions between glioma cells. This phenomenon can be used for the development of new methods of cell therapy of high-grade gliomas. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a mesenchymal stem cells |2 nationallicence | |
| 690 | 7 | |a glioblastoma multiforme |2 nationallicence | |
| 690 | 7 | |a C6 glioma |2 nationallicence | |
| 690 | 7 | |a connexin 43 |2 nationallicence | |
| 690 | 7 | |a gap junctions |2 nationallicence | |
| 700 | 1 | |a Gabashvili |D A. |u Department of Medical Nanobiotechnologies, Medico-Biological Faculty, N. I. Pirogov Russian National Research Medical University, Moscow, Russia |4 aut | |
| 700 | 1 | |a Baklaushev |D V. |u Department of Medical Nanobiotechnologies, Medico-Biological Faculty, N. I. Pirogov Russian National Research Medical University, Moscow, Russia |4 aut | |
| 700 | 1 | |a Grinenko |D N. |u Department of Fundamental and Applied Neurobiology, V. P. Serbsky State Research Center of Forensic and Social Psychiatry, Moscow, Russia |4 aut | |
| 700 | 1 | |a Levinskii |D A. |u Department of Medical Nanobiotechnologies, Medico-Biological Faculty, N. I. Pirogov Russian National Research Medical University, Moscow, Russia |4 aut | |
| 700 | 1 | |a Mel'nikov |D P. |u Department of Medical Nanobiotechnologies, Medico-Biological Faculty, N. I. Pirogov Russian National Research Medical University, Moscow, Russia |4 aut | |
| 700 | 1 | |a Cherepanov |D S. |u Department of Medical Nanobiotechnologies, Medico-Biological Faculty, N. I. Pirogov Russian National Research Medical University, Moscow, Russia |4 aut | |
| 700 | 1 | |a Chekhonin |D V. |u Department of Medical Nanobiotechnologies, Medico-Biological Faculty, N. I. Pirogov Russian National Research Medical University, Moscow, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/1(2015-05-01), 173-179 |x 0007-4888 |q 159:1<173 |1 2015 |2 159 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-2916-7 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-2916-7 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Gabashvili |D A. |u Department of Medical Nanobiotechnologies, Medico-Biological Faculty, N. I. Pirogov Russian National Research Medical University, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Baklaushev |D V. |u Department of Medical Nanobiotechnologies, Medico-Biological Faculty, N. I. Pirogov Russian National Research Medical University, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Grinenko |D N. |u Department of Fundamental and Applied Neurobiology, V. P. Serbsky State Research Center of Forensic and Social Psychiatry, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Levinskii |D A. |u Department of Medical Nanobiotechnologies, Medico-Biological Faculty, N. I. Pirogov Russian National Research Medical University, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Mel'nikov |D P. |u Department of Medical Nanobiotechnologies, Medico-Biological Faculty, N. I. Pirogov Russian National Research Medical University, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Cherepanov |D S. |u Department of Medical Nanobiotechnologies, Medico-Biological Faculty, N. I. Pirogov Russian National Research Medical University, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Chekhonin |D V. |u Department of Medical Nanobiotechnologies, Medico-Biological Faculty, N. I. Pirogov Russian National Research Medical University, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/1(2015-05-01), 173-179 |x 0007-4888 |q 159:1<173 |1 2015 |2 159 |o 10517 | ||